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Chemical Structure| 102717-29-3 Chemical Structure| 102717-29-3

Structure of 102717-29-3

Chemical Structure| 102717-29-3

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Product Details of [ 102717-29-3 ]

CAS No. :102717-29-3
Formula : C21H26O3Si
M.W : 354.52
SMILES Code : O=C1O[C@H](CO[Si](C2=CC=CC=C2)(C(C)(C)C)C3=CC=CC=C3)CC1
MDL No. :MFCD10569813

Safety of [ 102717-29-3 ]

Application In Synthesis of [ 102717-29-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 102717-29-3 ]

[ 102717-29-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10374-51-3 ]
  • [ 58479-61-1 ]
  • [ 102717-29-3 ]
YieldReaction ConditionsOperation in experiment
82% With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20℃; for 16.0h;Inert atmosphere; A solution of 10 (4.22 g, 36.35 mmol) in DMF (45 mL) was cooled to 0 C (ice bath). Imidazole (3.70 g, 54.35 mmol) was added, followed by TBDPSCl (11.3 mL, 43.46 mmol). After stirring at 0 C for 15 min the ice bath was removed and the mixture was stirred at room temperature for 16 h. After this time, the reaction mixture was partially concentrated at reduced pressure and the resulting residue was partitioned between EtOAc and water. The organic extract was washed with saturated NH4Cl, 5% LiCl, and brine, dried over Na2SO4, filtered and concentrated.The residue was purified by column chromatography (silica, gradient 0-40% EtOAc, hexanes) to provide 11 (10.51 g, 82%): 1H-NMR (500 MHz, CDCl3) delta 7.67-7.64 (m 4H), 7.46-7.38 (m, 6H), 4.60 (ddt, J = 8.1, 5.1, 3.2 Hz, 1H), 3.88 (dd,J = 11.4, 3.4 Hz, 1H), 3.69 (dd, J = 11.4, 3.4 Hz, 1H), 2.67 (ddd, J = 17.6, 10.3, 7.2 Hz, 1H), 2.51 (ddd, J = 17.8, 10.1,6.5 Hz, 1H), 2.33-2.18 (m, 2H), 1.06 (s, 9H). 13C-NMR (125 MHz, CDCl3) delta 177.4, 135.7, 135.5, 133.0, 132.6, 129.9,127.9, 80.0, 65.5, 28.6, 26.8, 23.7, 19.2. Mass spectral data could not be obtained.
 

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