[ CAS No. 1027345-07-8 ] {[proInfo.proName]}

Name: 1027345-07-8|4-Fluoro-3-((trifluoromethyl)sulfonyl)benzene-1-sulfonyl chloride|95%
Brand: Ambeed
SKU: A187776
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Quality Control of [ 1027345-07-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 1027345-07-8 ]

CAS No. :	1027345-07-8	MDL No. :	MFCD16883063
Formula :	C₇H₃ClF₄O₄S₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	SYZOKHJRIIDLOQ-UHFFFAOYSA-N
M.W :	326.67	Pubchem ID :	56972867
Synonyms :

Calculated chemistry of [ 1027345-07-8 ]

Physicochemical Properties

Num. heavy atoms :	18
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.14
Num. rotatable bonds :	3
Num. H-bond acceptors :	8.0
Num. H-bond donors :	0.0
Molar Refractivity :	52.77
TPSA :	85.04 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.52 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.34
Log Po/w (XLOGP3) :	2.49
Log Po/w (WLOGP) :	5.89
Log Po/w (MLOGP) :	1.92
Log Po/w (SILICOS-IT) :	1.86
Consensus Log Po/w :	2.7

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	1.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.48
Solubility :	0.107 mg/ml ; 0.000329 mol/l
Class :	Soluble
Log S (Ali) :	-3.92
Solubility :	0.0392 mg/ml ; 0.00012 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.0
Solubility :	0.0323 mg/ml ; 0.0000989 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	0.0
Synthetic accessibility :	2.53

Safety of [ 1027345-07-8 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310	UN#:	3265
Hazard Statements:	H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 1027345-07-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1027345-07-8 ]
Downstream synthetic route of [ 1027345-07-8 ]

[ 1027345-07-8 ] Synthesis Path-Upstream 1~4

1
[ 2358-41-0 ]
[ 1027345-07-8 ]

Yield	Reaction Conditions	Operation in experiment
88%	at 120℃; for 5 h;	A solution of 2.2 (10.00 g, 43.83 mmol) in HCISO3 (35.00 mL) was heated at 120 °C for 5 h. The mixturewas then poured into a mixture of crushed ice (100 g) in water (300 mL). The resulting mixture was extracted with DCM (80 mLx2), and the combined organic phases were washed with water (200 mLx2), dried over anhydrous Na2504 and concentrated to afford 2.3 (12.60 g, 38.57 mmol, 88percent yield), which was directly used in the next step without further purification. MS (ESI) m/z = 307 [M-Cl÷OH-H]. 1H NMR (400 MHz, DMSO-d6): ö8.25 (m, 1H), 8.15 (m, 1H), 7.73 (m, 1H).
62%	at 120℃; for 18 h;	Intermediate c (6.42 g) in chlorosulfonic acid (5.6 mL) at 120° C. was stirred for 18 hours, cooled to 25° C. and pipetted onto crushed ice. The mixture was extracted with <n="32"/>ethyl acetate, and the extract was washed with water and brine and dried (MgSO₄), filtered and concentrated to give 5.71 g of intermediate d (62percent yield).

Reference： [1] Patent: WO2017/101851, 2017, A1, . Location in patent: Paragraph 0135; 0138
[2] Patent: WO2008/61208, 2008, A2, . Location in patent: Page/Page column 30-31
[3] Synthesis, 2008, # 15, p. 2398 - 2404
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 21, p. 6902 - 6915
[5] Patent: US2009/318689, 2009, A1, . Location in patent: Page/Page column 34
[6] Chemical Communications, 2010, vol. 46, # 42, p. 8020 - 8022

2
[ 2557-78-0 ]
[ 1027345-07-8 ]

Reference： [1] Patent: WO2017/101851, 2017, A1,

3
[ 1978-16-1 ]
[ 1027345-07-8 ]

Reference： [1] Patent: WO2017/101851, 2017, A1,

4
[ 1027345-07-8 ]
[ 1027345-08-9 ]

Yield	Reaction Conditions	Operation in experiment
80%	With ammonia In water; isopropyl alcohol at -78℃; for 2 h;	Intermediate d (5.71 g) in isopropanol (175 mL) at -78° C was treated with ammonium hydroxide (24 mL) over 1 hour, stirred for 1 hour, quenched with 6M HCl (88 mL), warmed to 25° C. and concentrated. The concentrate was mixed with water and extracted with ethyl acetate. The extract was dried (MgSO₄), filtered and concentrated. The concentrate was recrystallized from ethyl acetate/hexane to give 4.33 g of intermediate 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide (80percent yield).

Reference： [1] Patent: WO2008/61208, 2008, A2, . Location in patent: Page/Page column 30; 31
[2] Synthesis, 2008, # 15, p. 2398 - 2404
[3] Patent: US2009/318689, 2009, A1, . Location in patent: Page/Page column 34
[4] Chemical Communications, 2010, vol. 46, # 42, p. 8020 - 8022
[5] Patent: WO2017/101851, 2017, A1, . Location in patent: Paragraph 0135; 0139

[ 1027345-07-8 ] Synthesis Path-Downstream 1~80

1
[ 1027345-07-8 ]
[ 1027345-08-9 ]

Yield	Reaction Conditions	Operation in experiment
80%	With ammonia; In water; isopropyl alcohol; at -78℃; for 2h;	Intermediate d (5.71 g) in isopropanol (175 mL) at -78 C was treated with ammonium hydroxide (24 mL) over 1 hour, stirred for 1 hour, quenched with 6M HCl (88 mL), warmed to 25 C. and concentrated. The concentrate was mixed with water and extracted with ethyl acetate. The extract was dried (MgSO4), filtered and concentrated. The concentrate was recrystallized from ethyl acetate/hexane to give 4.33 g of intermediate 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide (80% yield).
77%	With chlorosulfonic acid; ammonium hydroxide; In ethyl acetate; at 0℃; for 2h;	At 0 C,Ammonia water (80 mL) was added dropwise to a mixed solution of Compound V (76 g, 0.23 mol) and ethyl acetate (2.3 L). After the addition is completed, stirring is continued for 2 hours.Dilute hydrochloric acid (180 mL, 4 mol/L) was added dropwise to the reaction solution.Naturally warm to room temperature. Among them, the organic phase is washed with water and saturated brine.Dry over sodium sulfate and concentrate under reduced pressure to give a crude material.The crude product was recrystallized from ethanol/water (1:1, 105 mL) to give 55 g of white solid I.The yield was 77%.
	With ammonium hydroxide; at -50 - -40℃;Inert atmosphere;	EXAMPLE 154-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide; The solution from EXAMPLE 14 was charged into a flask fitted with overhead stirrer, nitrogen inlet, temperature probe and cooling bath. The solution was cooled down to -50 C. using an acetone/dry ice bath. Ammonium hydroxide (238 g) solution was slowly added to the reaction mixture through an additional funnel. The internal temperature was kept at about -40 C. HPLC showed the reaction was completed. The solution was cooled down to -60 C. 6 N HCl (600 g) was added to the reaction mixture slowly to keep the temperature under -35 C. The mixture was warmed up to room temperature. The layers were separated, and the organic layer was washed twice with 375 g of 4 N HCl. The organic layer was distilled down under vacuum with bath temperature from 40 to 50 C. Toluene (700 g) was added to the residue, and the mixture was stirred at room temperature for an hour. The mixture was filtered and washed with toluene to obtain the title compound.

Reference： [1]Patent: WO2008/61208,2008,A2 .Location in patent: Page/Page column 30; 31
[2]Patent: CN109851535,2019,A .Location in patent: Paragraph 0034; 0043; 0044
[3]Synthesis,2008,p. 2398 - 2404
[4]Patent: US2009/318689,2009,A1 .Location in patent: Page/Page column 34
[5]Chemical Communications,2010,vol. 46,p. 8020 - 8022
[6]Patent: WO2017/101851,2017,A1 .Location in patent: Paragraph 0135; 0139

2
[ 2358-41-0 ]
[ 1027345-07-8 ]

Yield	Reaction Conditions	Operation in experiment
88%	With chlorosulfonic acid; at 120℃; for 5h;	A solution of 2.2 (10.00 g, 43.83 mmol) in HCISO3 (35.00 mL) was heated at 120 C for 5 h. The mixturewas then poured into a mixture of crushed ice (100 g) in water (300 mL). The resulting mixture was extracted with DCM (80 mLx2), and the combined organic phases were washed with water (200 mLx2), dried over anhydrous Na2504 and concentrated to afford 2.3 (12.60 g, 38.57 mmol, 88% yield), which was directly used in the next step without further purification. MS (ESI) m/z = 307 [M-Cl÷OH-H]. 1H NMR (400 MHz, DMSO-d6): oe8.25 (m, 1H), 8.15 (m, 1H), 7.73 (m, 1H).
86%	With chlorosulfonic acid; at 120℃;	Compound IV (60 g, 0.26 mol) and chlorosulfonic acid (150 mL) were heated at 120 C.Until the raw materials disappear. After cooling to room temperature, the reaction solution was added dropwise to ice water (1.5 kg), extracted with ethyl acetate, washed with water and brine.After drying over sodium sulfate and concentration under reduced pressure, 74 g of a brown oily liquid V was obtained, yield 86%.
62%	With chlorosulfonic acid; at 120℃; for 18h;	Intermediate c (6.42 g) in chlorosulfonic acid (5.6 mL) at 120 C. was stirred for 18 hours, cooled to 25 C. and pipetted onto crushed ice. The mixture was extracted with <n="32"/>ethyl acetate, and the extract was washed with water and brine and dried (MgSO4), filtered and concentrated to give 5.71 g of intermediate d (62% yield).

EXAMPLE 144-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonyl chloride; EXAMPLE 13 (80 g) was charged to a reactor fitted with overhead stirrer, nitrogen inlet, condenser, scrubber, temperature probe and heating bath. Chlorosulfonic acid (307 g) was added slowly through an additional funnel. The mixture was then heated up to 120 C. and held for 22 hours at 120 C. The mixture was cooled down to room temperature. Thionyl chloride (118 g) was added to the reaction mixture in one portion at ambient temperature. The mixture was stirred at 25 C. for 24 hours. A sample was pulled and HPLC showed the reaction was completed with 1.1% of the sulfonic acid left. Isopropyl acetate (775 g) was cooled down to -50 C. Water (600 g) was charged to isopropyl acetate solution. The reaction mixture was transferred slowly to the isopropyl acetate/ice mixture through an additional funnel. The internal temperature increased to 0.8 C. during the addition. The cold reaction mixture was warmed up 15 C. and layers were separated. The organic layer was used in the next step (EXAMPLE 15) without isolation.

Reference： [1]Patent: WO2017/101851,2017,A1 .Location in patent: Paragraph 0135; 0138
[2]Patent: CN109851535,2019,A .Location in patent: Paragraph 0034; 0041; 0042
[3]Patent: WO2008/61208,2008,A2 .Location in patent: Page/Page column 30-31
[4]Synthesis,2008,p. 2398 - 2404
[5]Journal of Medicinal Chemistry,2008,vol. 51,p. 6902 - 6915
[6]Patent: US2009/318689,2009,A1 .Location in patent: Page/Page column 34
[7]Chemical Communications,2010,vol. 46,p. 8020 - 8022

3
[ 1027345-07-8 ]
C₃₁H₃₃ClN₄O₂ [ No CAS ]
[ 1402141-72-3 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

4
[ 1027345-07-8 ]
C₃₂H₃₅ClN₄O₂ [ No CAS ]
[ 1402141-73-4 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

5
[ 1027345-07-8 ]
C₃₀H₃₁ClN₄O₂ [ No CAS ]
[ 1391107-54-2 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

6
[ 1027345-07-8 ]
C₃₀H₃₁ClN₄O₂ [ No CAS ]
[ 1402141-74-5 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

7
[ 1027345-07-8 ]
C₃₁H₃₃ClN₄O₂ [ No CAS ]
[ 1391107-57-5 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

8
[ 1027345-07-8 ]
C₃₁H₃₃ClN₄O₂ [ No CAS ]
[ 1402141-75-6 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

9
[ 1027345-07-8 ]
[ 1384513-14-7 ]
[ 1402141-65-4 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

10
[ 1027345-07-8 ]
(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylic acid trifluoroacetic acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

11
[ 1027345-07-8 ]
[ 1391107-43-9 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

12
[ 1027345-07-8 ]
[ 1402141-62-1 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

13
[ 1027345-07-8 ]
[ 1402141-63-2 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

14
[ 1027345-07-8 ]
[ 1391107-78-0 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

15
[ 1027345-07-8 ]
[ 1391107-81-5 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

16
[ 1027345-07-8 ]
[ 1391107-31-5 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

17
[ 1027345-07-8 ]
(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(4-(4-(4-hydroxy-4-methylpiperidin-1-yl)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylic acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8502 - 8514,13

18
[ 1027345-07-8 ]
[ 1616557-88-0 ]
C₂₆H₂₉F₄N₃O₇S₂ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 3026 - 3033

19
[ 1027345-07-8 ]
[ 1619923-52-2 ]
[ 1619923-53-3 ]

Yield	Reaction Conditions	Operation in experiment
3.2 g		N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide (B) To a solution of A (3.0 g, 4.9 mmol) in 150 mL of methanol was added 10% wt. Pd/C (300 mg, 0.1 eq. m/m). The solution was stirred under hydrogen atmosphere at room temperature for about 20 min until no A was observed by TLC. The reaction mixture was filtered and the filtrate was concentrated in vacuum. The residue was used for next step directly without purification. To the solution of this aniline in pyridine, <strong>[1027345-07-8]4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride</strong> (1.8 g, 5.4 mmol) was added at 0 C. The mixture was stirred at 0 C. to room temperature for 1 hour until no aniline was observed by TLC. Water (10 mL) was added and extracted with ethyl acetate (200 mL*2). The combined ethyl acetate solution was washed with brine (150 mL), dried over sodium sulfate and concentrated in vacuo. The concentrate was flash chromatographed on silica gel with 40% EtOA/hexane to provide intermediate B (3.2 g, yield 75% over two steps). MS (ESI) m/z 931.75 (M+K)+.

Reference： [1]Patent: US2014/199234,2014,A1 .Location in patent: Paragraph 0142

20
[ 1027345-07-8 ]
[ 1619923-39-5 ]

Reference： [1]Patent: US2014/199234,2014,A1

21
[ 1027345-07-8 ]
(R)-1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoro methylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yl dihydrogen phosphate trifluoroacetate [ No CAS ]

Reference： [1]Patent: US2014/199234,2014,A1

22
[ 1027345-07-8 ]
[ 1619923-27-1 ]

Reference： [1]Patent: US2014/199234,2014,A1

23
[ 2557-78-0 ]
[ 1027345-07-8 ]

Reference： [1]Patent: WO2017/101851,2017,A1
[2]Patent: CN109851535,2019,A

24
[ 1978-16-1 ]
[ 1027345-07-8 ]

Reference： [1]Patent: WO2017/101851,2017,A1
[2]Patent: CN109851535,2019,A

25
[ 1027345-07-8 ]
C₅₇H₇₅ClF₃N₆O₁₀PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

26
[ 1027345-07-8 ]
[[4-[(3R)-3-[4-[[4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-cyclohexen-1-yl]methyl]piperazin-1-yl]benzoyl]sulfamoyl]-2-(trifluoromethylsulfonyl)anilino]-4-phenylsulfanyl-butyl]piperazin-1-yl]methyl-ethoxy-phosphoryl]oxymethyl isopropyl carbonate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

27
[ 1027345-07-8 ]
C₆₂H₈₃ClF₃N₆O₁₂PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

28
[ 1027345-07-8 ]
(diethyl (R)-((1-(3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)4-(phenylthio)butyl)piperidine-4-ylidene)methyl)phosphonate) [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

29
[ 1027345-07-8 ]
(diethyl (R)-((4-(3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)methyl)phosphonate) [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

30
[ 1027345-07-8 ]
C₅₂H₆₇ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

31
[ 1027345-07-8 ]
(((2-(4-((R)-3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)ethyl)(hydroxy)phosphoryl)oxy)methyl pivalate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

32
[ 1027345-07-8 ]
(R)-(((2-(4-(3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)ethyl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate) [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1
[2]Patent: WO2017/101851,2017,A1
[3]Patent: WO2017/101851,2017,A1

33
[ 1027345-07-8 ]
(diethyl (R)-((1-(3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperidin-4-yl)methyl)phosphonate) [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

34
[ 1027345-07-8 ]
((((1-((R)-3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperidin-4-yl)methyl)(ethoxy)phosphoryl)oxy)methyl pivalate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

35
[ 1027345-07-8 ]
(ethyl hydrogen ((1-((R)-3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperidin-4-yl)methyl)phosphonate) [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

36
[ 1027345-07-8 ]
C₅₁H₆₀ClF₃N₅O₈PS₃*ClH [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

37
[ 1027345-07-8 ]
C₅₀H₅₉ClF₃N₆O₈PS₃*ClH [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

38
[ 1027345-07-8 ]
(ethyl hydrogen ((4-((R)-3-((4-(N-(4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)methyl)phosphonate) [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

39
[ 1027345-07-8 ]
(ethyl hydrogen ((4-((R)-3-((4-(N-(4-(4-((4-chloro-[1,1-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)methyl)phosphonate) [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

40
[ 1027345-07-8 ]
((((4-((R)-3-((4-(N-(4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)methyl)(ethoxy)phosphoryl)oxy)methyl pivalate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

41
[ 1027345-07-8 ]
C₅₅H₆₆ClF₃N₅O₁₀PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

42
[ 1027345-07-8 ]
((((4-((R)-3-((4-(N-(4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)methyl)(ethoxy)phosphoryl)oxy)methyl isopropyl carbonate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

43
[ 1027345-07-8 ]
C₅₄H₆₄ClF₃N₅O₁₁PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

44
[ 1027345-07-8 ]
diethyl (R)-(2-(4-(4-(phenylthio)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl) phenyl)amino)butyl)piperazin-1-yl)ethyl)phosphonate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

45
[ 1027345-07-8 ]
diethyl (R)-(2-(methyl(4-(phenylth io)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl)phenyl)amino)butyl)amino)ethyl)phosphonate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

46
[ 1027345-07-8 ]
dimethyl (R)-((4-(4-(phenylthio)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl)phenyl)amino)butyl)piperazin-1-yl)methyl)phosphonate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

47
[ 1027345-07-8 ]
4-[[(1R)-3-[4-(3-diethoxyphosphorylpropyl)piperazin-1-yl]-1-(phenylsulfanylmethyl)propyl]amino]-3-(trifluoromethylsulfonyl)benzenesulfonamide [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

48
[ 1027345-07-8 ]
(x)C₂HF₃O₂*C₃₀H₄₄F₃N₄O₉PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

49
[ 1027345-07-8 ]
C₂₅H₃₆F₃N₄O₇PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

50
[ 1027345-07-8 ]
C₂₉H₄₂F₃N₄O₁₀PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

51
[ 1027345-07-8 ]
C₂₇H₃₇F₃N₃O₇PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

52
[ 1027345-07-8 ]
C₂₆H₃₈F₃N₄O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

53
[ 1027345-07-8 ]
C₂₇H₃₉F₃N₃O₇PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

54
[ 1027345-07-8 ]
4-[[(1R)-3-[4-(3-dimethoxyphosphorylpropyl)piperazin-1-yl]-1-(phenylsulfanylmethyl)propyl]amino]-3-(trifluoromethylsulfonyl)benzenesulfonamide [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

55
[ 1027345-07-8 ]
C₅₁H₆₅ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

56
[ 1027345-07-8 ]
diethyl (R)-((4-(4-(phenylthio)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl)phenyl)amino)butyl)piperazin-1-yl)methyl)phosphonate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

57
[ 1027345-07-8 ]
C₅₁H₆₅ClF₃N₆O₈PS₃*(x)ClH [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1
[2]Patent: WO2017/101851,2017,A1

58
[ 1027345-07-8 ]
C₄₈H₅₉ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1
[2]Patent: WO2017/101851,2017,A1

59
[ 1027345-07-8 ]
C₅₀H₆₃ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1
[2]Patent: WO2017/101851,2017,A1

60
[ 1027345-07-8 ]
C₅₃H₆₉ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

61
[ 1027345-07-8 ]
C₅₀H₆₄ClF₃N₅O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

62
[ 1027345-07-8 ]
C₄₈H₆₀ClF₃N₅O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

63
[ 1027345-07-8 ]
C₄₆H₅₆ClF₃N₅O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

64
[ 1027345-07-8 ]
C₄₈H₅₉ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

65
[ 1027345-07-8 ]
C₅₀H₆₃ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

66
[ 1027345-07-8 ]
C₅₄H₇₁ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

67
[ 1027345-07-8 ]
C₅₂H₆₇ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

68
[ 1027345-07-8 ]
C₅₆H₇₅ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1
[2]Patent: WO2017/101851,2017,A1

69
[ 1027345-07-8 ]
((((4-((R)-3-((4-(N-(4-(4-((4-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)methyl)(ethoxy)phosphoryl)oxy)methyl pivalate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

70
[ 1027345-07-8 ]
C₅₂H₆₇ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

71
[ 1027345-07-8 ]
C₅₀H₆₃ClF₃N₆O₈PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

72
[ 1027345-07-8 ]
C₅₈H₇₇ClF₃N₆O₁₀PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

73
[ 1027345-07-8 ]
((4-(2-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-3-(phenylthio)propyl)piperazin-1-yl)methyl)phosphonate [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

74
[ 1027345-07-8 ]
C₅₇H₇₅ClF₃N₆O₁₁PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

75
[ 1027345-07-8 ]
C₅₅H₇₁ClF₃N₆O₁₀PS₃ [ No CAS ]

Reference： [1]Patent: WO2017/101851,2017,A1

76
[ 88-74-4 ]
[ 1027345-07-8 ]

Reference： [1]Patent: CN109851535,2019,A

77
[ 2905-21-7 ]
[ 1027345-07-8 ]

Reference： [1]Patent: CN109851535,2019,A

78
[ 52200-99-4 ]
[ 1027345-07-8 ]

Reference： [1]Patent: CN109851535,2019,A

79
[ 365-33-3 ]
[ 1027345-07-8 ]

Reference： [1]Patent: CN109851535,2019,A

80
[ 384-37-2 ]
[ 1027345-07-8 ]

Reference： [1]Patent: CN109851535,2019,A

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1027345-07-8 ] {[proInfo.proName]}

Quality Control of [ 1027345-07-8 ]

Related Doc. of [ 1027345-07-8 ]

Product Details of [ 1027345-07-8 ]

Calculated chemistry of [ 1027345-07-8 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 1027345-07-8 ]

Application In Synthesis of [ 1027345-07-8 ]

[ 1027345-07-8 ] Synthesis Path-Upstream 1~4

[ 1027345-07-8 ] Synthesis Path-Downstream 1~80

Related Functional Groups of [ 1027345-07-8 ]

Fluorinated Building Blocks

Aryls

Sulfonyl Chlorides

Chlorides

Sulfones

Trifluoromethyls

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 1027345-07-8 ]