Home Cart 0 Sign in  
X

[ CAS No. 383-29-9 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 383-29-9
Chemical Structure| 383-29-9
Structure of 383-29-9 * Storage: {[proInfo.prStorage]}

Quality Control of [ 383-29-9 ]

Related Doc. of [ 383-29-9 ]

SDS
Alternatived Products of [ 383-29-9 ]
Alternatived Products of [ 383-29-9 ]

Product Details of [ 383-29-9 ]

CAS No. :383-29-9 MDL No. :MFCD00000350
Formula : C12H8F2O2S Boiling Point : 367.9°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :254.25 g/mol Pubchem ID :67842
Synonyms :

Safety of [ 383-29-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 383-29-9 ]

  • Upstream synthesis route of [ 383-29-9 ]
  • Downstream synthetic route of [ 383-29-9 ]

[ 383-29-9 ] Synthesis Path-Upstream   1~15

  • 1
  • [ 824-80-6 ]
  • [ 383-29-9 ]
YieldReaction ConditionsOperation in experiment
88% With copper diacetate In acetonitrile at 60℃; for 3 h; General procedure: A mixture of the sodium arylsulfinate (1 mmol), Cu(OAc)2 (0.5 mmol)and CH3CN (1 mL) was stirred at 60 °C in air for 3 h. After this, themixture was cooled to room temperature and filtered through a filterpaper. The organic phases were evaporated under reduced pressure andthe residue was subjected to flash column chromatography (silica gel,ethyl acetate/petroleum ether = 1/10) to obtain the desired product.All products are known compounds and were characterised by 1HNMR, 13C NMR and HRMS.
Reference: [1] Journal of Chemical Research, 2014, vol. 38, # 5, p. 265 - 268
  • 2
  • [ 368-88-7 ]
  • [ 383-29-9 ]
YieldReaction ConditionsOperation in experiment
58% With chlorosulfonic acid In fluorobenzene; water EXAMPLE 4
A 194 g (1.1 moles) quantity of 4-fluorobenzenesulfonic acid was added to 96 g (1 mole) of fluorobenzene and the mixture was cooled with water while 123 g (1.1 moles) of chlorosulfonic acid was added at about 10° to about 20° C. over a period of 1 hour.
After the addition, the reaction mixture was stirred for 3 hours while being maintained at 20° to 30° C.
The hydrochloric acid gas evolved during the reaction was continuously removed from the reaction system.
After the completion of the reaction, about 400 ml of water was added to the reaction mixture, and 9.6 g (0.1 mole) of the unreacted fluorobenzene was recovered by distillation.
Separation of the precipitate by filtration gave 65 g of 4,4'-difluorodiphenylsulfone in 58percent yield. M.P. 97° to 98° C.
Purity of 99.7percent.
Reference: [1] Patent: US4558161, 1985, A,
  • 3
  • [ 462-06-6 ]
  • [ 383-29-9 ]
Reference: [1] Chemical Communications, 2014, vol. 50, # 95, p. 15037 - 15040
[2] Journal of the American Chemical Society, 1940, vol. 62, p. 511,512
[3] Acta Chimica Academiae Scientiarum Hungaricae, 1954, vol. 4, p. 111,115
[4] Journal of the American Chemical Society, 1948, vol. 70, p. 1564,1565
  • 4
  • [ 17763-90-5 ]
  • [ 383-29-9 ]
Reference: [1] Organic Letters, 2013, vol. 15, # 21, p. 5602 - 5605
  • 5
  • [ 462-06-6 ]
  • [ 349-88-2 ]
  • [ 383-29-9 ]
Reference: [1] Tetrahedron Letters, 2004, vol. 45, # 7, p. 1499 - 1501
[2] Chemische Berichte, 1953, vol. 86, p. 172,180
  • 6
  • [ 80-09-1 ]
  • [ 383-29-9 ]
Reference: [1] Patent: US6242654, 2001, B1,
[2] Organic Letters, 2013, vol. 15, # 21, p. 5602 - 5605
  • 7
  • [ 349-88-2 ]
  • [ 352-33-0 ]
  • [ 383-29-9 ]
  • [ 398-23-2 ]
  • [ 404-38-6 ]
Reference: [1] Tetrahedron Letters, 2005, vol. 46, # 42, p. 7125 - 7128
  • 8
  • [ 395-25-5 ]
  • [ 383-29-9 ]
Reference: [1] Russian Journal of Organic Chemistry, 1995, vol. 31, # 11, p. 1520 - 1525[2] Zhurnal Organicheskoi Khimii, 1995, vol. 31, # 11, p. 1692 - 1697
[3] Acta Chimica Academiae Scientiarum Hungaricae, 1954, vol. 4, p. 111,115
[4] Magnetic Resonance in Chemistry, 1989, vol. 27, # 4, p. 360 - 367
[5] Journal of the Chemical Society, Chemical Communications, 1982, # 23, p. 1352 - 1353
[6] Canadian Journal of Chemistry, 1987, vol. 65, p. 2421 - 2424
[7] Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1986, vol. 25, # 7, p. 678 - 680
[8] Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1989, vol. 28, # 3, p. 250 - 252
[9] Tetrahedron, 2001, vol. 57, # 7, p. 1369 - 1374
[10] Journal of the American Chemical Society, 1948, vol. 70, p. 1564,1565
  • 9
  • [ 1156-50-9 ]
  • [ 383-29-9 ]
Reference: [1] Journal of Fluorine Chemistry, 1995, vol. 70, # 2, p. 201 - 206
  • 10
  • [ 404-38-6 ]
  • [ 383-29-9 ]
Reference: [1] Journal of the American Chemical Society, 1948, vol. 70, p. 1564,1565
  • 11
  • [ 462-06-6 ]
  • [ 383-29-9 ]
  • [ 141223-27-0 ]
  • [ 141223-28-1 ]
Reference: [1] Journal of Organic Chemistry, 1992, vol. 57, # 13, p. 3738 - 3740
  • 12
  • [ 462-06-6 ]
  • [ 383-29-9 ]
  • [ 368-88-7 ]
Reference: [1] Synthesis, 1988, # 9, p. 674 - 679
  • 13
  • [ 7790-94-5 ]
  • [ 462-06-6 ]
  • [ 383-29-9 ]
Reference: [1] Journal of the American Chemical Society, 1948, vol. 70, p. 654,656
[2] Journal of the American Chemical Society, 1940, vol. 62, p. 511,512
  • 14
  • [ 383-29-9 ]
  • [ 108-95-2 ]
  • [ 1623-91-2 ]
YieldReaction ConditionsOperation in experiment
221 g With potassium carbonate In N,N-dimethyl acetamide; toluene at 165℃; for 2 h; Inert atmosphere; Dean-Stark To a three-neck flask equipped with a stirrer, nitrogen supply tube, and Dean-Stark trap, 228 g of potassium carbonate (reagent manufactured by Aldrich), 200 g of 4,4'-difluorodiphenyl sulfone, and 155 g of phenol were fed, followed by nitrogen purge, dehydration in 500 mL of N,N-dimethyl acetamide (DMAc) and 200 mL of toluene at 150° C., heating to remove toluene, and reaction at 165° C. for 2 hours.
The resulting material was separated and extracted with chloroform/water, washed with methanol, and dried to obtain 221 g of a tetraphenyl compound.
First, 221 g of the resulting tetraphenyl compound and 227 g of aluminum chloride were dissolved in 570 mL of dichloromethane, and then a dichloromethane solution (100 mL) containing 224 g of 4-fluorobenzenesulfonyl chloride was dropped at 0° C., followed by gradual heating to room temperature and reaction for 4 hours.
Reference: [1] Patent: US2014/213671, 2014, A1, . Location in patent: Paragraph 0188-0189
  • 15
  • [ 383-29-9 ]
  • [ 139-02-6 ]
  • [ 1623-91-2 ]
Reference: [1] Patent: US2017/240723, 2017, A1, . Location in patent: Paragraph 0118; 0119
Historical Records

Related Functional Groups of
[ 383-29-9 ]

Fluorinated Building Blocks

Chemical Structure| 657-46-5

[ 657-46-5 ]

1-Fluoro-3-(methylsulfonyl)benzene

Similarity: 0.94

Chemical Structure| 424792-57-4

[ 424792-57-4 ]

1,2-Difluoro-4-(methylsulfonyl)benzene

Similarity: 0.91

Chemical Structure| 1147557-74-1

[ 1147557-74-1 ]

2,6-Difluoro-4-(methylsulfonyl)aniline

Similarity: 0.71

Chemical Structure| 957060-85-4

[ 957060-85-4 ]

2-Fluoro-4-(methylsulfonyl)phenylboronic acid

Similarity: 0.67

Chemical Structure| 349-88-2

[ 349-88-2 ]

4-Fluorobenzene-1-sulfonyl chloride

Similarity: 0.63

Sulfones

Chemical Structure| 657-46-5

[ 657-46-5 ]

1-Fluoro-3-(methylsulfonyl)benzene

Similarity: 0.94

Chemical Structure| 424792-57-4

[ 424792-57-4 ]

1,2-Difluoro-4-(methylsulfonyl)benzene

Similarity: 0.91

Chemical Structure| 127-63-9

[ 127-63-9 ]

Sulfonyldibenzene

Similarity: 0.82

Chemical Structure| 5535-48-8

[ 5535-48-8 ]

(Vinylsulfonyl)benzene

Similarity: 0.80

Chemical Structure| 3112-85-4

[ 3112-85-4 ]

Methyl phenyl sulfone

Similarity: 0.78

Aryls

Chemical Structure| 657-46-5

[ 657-46-5 ]

1-Fluoro-3-(methylsulfonyl)benzene

Similarity: 0.94

Chemical Structure| 424792-57-4

[ 424792-57-4 ]

1,2-Difluoro-4-(methylsulfonyl)benzene

Similarity: 0.91

Chemical Structure| 127-63-9

[ 127-63-9 ]

Sulfonyldibenzene

Similarity: 0.82

Chemical Structure| 5535-48-8

[ 5535-48-8 ]

(Vinylsulfonyl)benzene

Similarity: 0.80

Chemical Structure| 3112-85-4

[ 3112-85-4 ]

Methyl phenyl sulfone

Similarity: 0.78