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Chemical Structure| 1028268-32-7 Chemical Structure| 1028268-32-7

Structure of 1028268-32-7

Chemical Structure| 1028268-32-7

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Product Details of [ 1028268-32-7 ]

CAS No. :1028268-32-7
Formula : C24H23ClN2O6
M.W : 470.90
SMILES Code : O=C(OCC)C(CC1=CC(NC2=C1C=CC=C2)=O)(NC(C3=CC=C(Cl)C=C3)=O)C(OCC)=O

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Application In Synthesis of [ 1028268-32-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1028268-32-7 ]

[ 1028268-32-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 64-17-5 ]
  • [ 4876-10-2 ]
  • [ 81918-01-6 ]
  • [ 1028268-32-7 ]
YieldReaction ConditionsOperation in experiment
8.02 g (81.1%) With sodium; In water; EXAMPLE 3 Synthesis of Ethyl 2-(4-chlorobenzoylamino)-2-ethoxycarbonyl-3-[2(1H)-quinolinon-4-yl]propionate Sodium ethylate was prepared from 0.48 g of sodium and 100 ml of anhydrous ethyl alcohol. After adding 6.59 g of diethyl 4-chlorobenzamidomalonate, the mixture was stirred at the room temperature for one hour. 5.00 g of 4-bromomethylcarbostyril was added and the mixture was subjected to reflux stirring for 2 hours. After the completion of the reaction, the ethyl alcohol was removed through vacuum distillation and water was added to the residue for crystallization. The crystal thus obtained was filtered and dried to yield 8.02 g (81.1%) of ethyl 2-(4-chlorobenzoylamino)-2-ethoxycarbonyl-3-[2(1H)-quinolinon-4-yl]propionate. Melting point: 213.3~214.5 C.; and 1H NMR (CDCl3, 500 MHz) (ppm): 1.29-1.32 (m,6H), 4.05 (s,2H), 4.24-4.36 (m,4H), 6.45 (s,1H), 6.98-7.00 (m,1H), 7.33-7.41 (m,4H), 7.54-7.56 (m,1H), 7.70-7.71 (d,2H), 12.19 (br,1H).
  • 2
  • [ 4876-10-2 ]
  • [ 81918-01-6 ]
  • [ 1028268-32-7 ]
YieldReaction ConditionsOperation in experiment
88% 2) 0.96g of sodium was added to 200ml of absolute ethanol,Heat until the sodium is completely dissolved in ethanol,Cooled to room temperature for use; then 13.2g of the product obtained in step 1)Diethyl 4-chlorobenzamidomalonate was added to sodium ethoxide solution,Stir at room temperature for 1.5h, and then add 9.8g dropwise to the reaction mixture 4 - bromomethyl quinolone, stirred at room temperature to the point of disappearance of raw materials,After the reaction was completed, the ethanol was concentrated under reduced pressure to obtain a crude product2- (4-chlorobenzamido) -2-Ethoxycarbonyl-3-[2 (1H) -quinuclidin-4-yl]Ethyl propionate,The crude product was placed in a mixed solvent of dichloromethane and water recrystallization,Get fine2- (4-chlorobenzamido) -2-Ethoxycarbonyl-3- [2 (1H) -4-yl] propionate17.6g (yield: 88%).
 

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