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Chemical Structure| 1028842-43-4 Chemical Structure| 1028842-43-4

Structure of 1028842-43-4

Chemical Structure| 1028842-43-4

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Product Details of [ 1028842-43-4 ]

CAS No. :1028842-43-4
Formula : C8H6ClF3N2O
M.W : 238.59
SMILES Code : N/C(C1=CC=C(C(F)(F)F)C=C1Cl)=N\O

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Application In Synthesis of [ 1028842-43-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1028842-43-4 ]

[ 1028842-43-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1813-33-8 ]
  • [ 1028842-43-4 ]
YieldReaction ConditionsOperation in experiment
With hydroxylamine hydrochloride; triethylamine; In ethanol; at 50℃; for 3.5h; To a solution of <strong>[1813-33-8]2-chloro-4-(trifluoromethyl)benzonitrile</strong> (500 mg, 2.43 mmol) in 12 ml ethanol was added hydroxylammonium chloride (253 mg, 3.65 mmol) and triethylamine (320 mg, 3.16 mmol) and then the reaction mixture was stirred 3.5 h at 50 C. After cooling to RT, the solvent was evaporated and the crude was solved in ethyl acetate and extracted with water and brine solution. The organic phase was dried over magnesium sulfate, filtered and evaporated under vacuum to yield the title compound (481 mg, 67 % of theory, purity 80%). The compound was used without further purification. LC-MS (method 3B): RT = 1.49 min, m/z = 239 (M+H)+
 

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