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Chemical Structure| 103323-26-8 Chemical Structure| 103323-26-8

Structure of 103323-26-8

Chemical Structure| 103323-26-8

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Product Details of [ 103323-26-8 ]

CAS No. :103323-26-8
Formula : C10H12O2
M.W : 164.20
SMILES Code : O=CC1=CC=C(OC)C(CC)=C1
MDL No. :MFCD06247460

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Application In Synthesis of [ 103323-26-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 103323-26-8 ]

[ 103323-26-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33839-11-1 ]
  • [ 103323-26-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 178.1 A solution of <strong>[33839-11-1]4-bromo-2-ethyl-1-methoxybenzene</strong> (J. Chem. Soc., Perkin Trans. 1, 1987, 1423; 2.13 g, 9.9 mmol) in THF (30 ml) was cooled to -78 C. A 1.6M solution of n-BuLi in hexane (7.42 ml, 11.9 mmol) was added slowly and the mixture was stirred for 1.5 h. at -78 C. The mixture was warmed slowly to -10 C. and subsequently again cooled to -78 C. DMF (2.29 ml, 29.7 mmol) was added slowly and the mixture was stirred for 1 h. at -78 C. and for 1 h. at 0 C. The reaction mixture was poured into ice-cold 3M HCl and extracted with diethyl ether. The organic phase was dried and filtered, and the filtrate was concentrated. The residue was purified by chromatography (SiO2, hexane/EtOAc 8:1=>2:1). There were obtained 690 mg (42%) of 3-ethyl-4-methoxy-benzaldehyde as a yellowish liquid.
 

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