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[ CAS No. 10338-51-9 ] {[proInfo.proName]}

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Chemical Structure| 10338-51-9
Chemical Structure| 10338-51-9
Structure of 10338-51-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 10338-51-9 ]

CAS No. :10338-51-9 MDL No. :
Formula : C14H20O7 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 300.30 Pubchem ID :-
Synonyms :
Rhodioloside

Calculated chemistry of [ 10338-51-9 ]

Physicochemical Properties

Num. heavy atoms : 21
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.57
Num. rotatable bonds : 5
Num. H-bond acceptors : 7.0
Num. H-bond donors : 5.0
Molar Refractivity : 71.78
TPSA : 119.61 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -8.88 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.04
Log Po/w (XLOGP3) : -1.05
Log Po/w (WLOGP) : -1.25
Log Po/w (MLOGP) : -1.22
Log Po/w (SILICOS-IT) : -0.48
Consensus Log Po/w : -0.59

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.92
Solubility : 36.0 mg/ml ; 0.12 mol/l
Class : Very soluble
Log S (Ali) : -0.97
Solubility : 31.9 mg/ml ; 0.106 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.44
Solubility : 108.0 mg/ml ; 0.361 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 4.26

Safety of [ 10338-51-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 10338-51-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 10338-51-9 ]
  • Downstream synthetic route of [ 10338-51-9 ]

[ 10338-51-9 ] Synthesis Path-Upstream   1~28

  • 1
  • [ 28251-63-0 ]
  • [ 10338-51-9 ]
YieldReaction ConditionsOperation in experiment
89.8% With sodium methylate In methanol at 20℃; for 2 h; 3) 1 g of sodium methoxide (50percent content) in methanol was added to the filtrate, and the mixture was stirred at room temperature for 2 hours. Acidic cation exchange resin (732) was to adjust the pH to 7, filtered and the filtrate was removed. The filtrate was added with activated carbon (2percent) and decolorized at 70 ° C for 1 hour, filtererd, the filtrate was concentrated under reduced pressure and dissolved in 15 ml of water. The mixture was extracted 4 times with ethyl acetate (10 ml / time), the organic phase was separated. The water phase was combined, the aqueous phase was concentrated to half volume at 60 ° C under reduced pressure, extracted 4 times with n-butanol (10ml / time), the aqueous phase was separated, and the organic phases were combined. The organic phase was rotated under reduced pressure to spin-out n-butanol to give a concentrate. 4) The concentrate was recrystallized from acetone: n-butanol = 3:1 to obtain 2.30 g of salidroside, the yield is 89.8percent, purity 98percent.
Reference: [1] Tetrahedron, 1989, vol. 45, # 12, p. 3673 - 3682
[2] Patent: CN104045669, 2016, B, . Location in patent: Page/Page column 0024; 0027-0030; 0033-0035; 0038-0040; 0043; 0044
[3] Phytochemistry, 1988, vol. 27, # 6, p. 1813 - 1816
[4] Synthetic Communications, 2011, vol. 41, # 17, p. 2594 - 2600
  • 2
  • [ 39032-08-1 ]
  • [ 10338-51-9 ]
YieldReaction ConditionsOperation in experiment
90% With sodium methylate In methanol at 4℃; General procedure: Glycoside 21a–c, 22, 23 and 25–30 was dissolved in dry MeOH (9 mL), cooled to 4 °C and 0.5 M MeONa (1 mL) was added dropwise. The mixture was stirred at 4 °C until TLC (EtOAc/MeOH 6:1) showed that the reaction is complete. The pH of the mixture was brought pH 5 using Amberlite IR 120 (H+ form). The resin was filtered off, the filtrate concentrated and the residue was subjected to column chromatography (EtOAc/MeOH 1:06:1).
86.5% With strongly acidic cation exchange resin 717 In ethanol at 70℃; 2-(4-acetoxyphenyl)ethyl(2,3,4,6-O-tetraacetyl)-β-D-glucopyranoside 30 g was added 500 mL round bottom flask 95percent ethanol 717 strong acidic cationic resin 20g, 70 reflux overnight, TLC tracking to complete reaction, cooling to room temperature, the cationic resin recovery, ethanol and water were distilled off under reduced pressure, 100 ml of ethyl acetate was added, and the mixture was refluxed for 1 hour and then slowly cooled to room temperature, precipitation of white solid, filter, 40-60 dryness 10-12 hours to give salidroside, purity 98.2percent, yield 86.5percent.
Reference: [1] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 4, p. 581 - 586
[2] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 524 - 530
[3] Patent: CN106674300, 2017, A, . Location in patent: Paragraph 0071-0072
  • 3
  • [ 183209-56-5 ]
  • [ 10338-51-9 ]
YieldReaction ConditionsOperation in experiment
93% With 5%-palladium/activated carbon; hydrogen In methanol at 20℃; Darkness; Green chemistry 1.1 g (2.8 mmol) of 1-O-(4-benzyloxy)-phenylethyl yl -β-D- glucopyranoside and 5percent Pd / C 0.1 g of catalyst, and then repeatedly evacuated air charge of hydrogengas 3-5 times, and 20 mL of anhydrous methanol, protected from light, stirred at room temperature under a hydrogen atmosphere overnight.Filtration, concentration to dryness under reduced pressure,and recrystallized from ethanol to give 1-(4-hydroxy)-phenethyl-β-D-s-glucopyranoside as a white powder, which is aweight of 0.78 g. The yield was 93percent.
Reference: [1] Patent: CN107880085, 2018, A, . Location in patent: Paragraph 0039
[2] Chemical and Pharmaceutical Bulletin, 2010, vol. 58, # 12, p. 1627 - 1629
  • 4
  • [ 133-99-3 ]
  • [ 501-94-0 ]
  • [ 10338-51-9 ]
YieldReaction ConditionsOperation in experiment
6.7% With β-glucosidase from Aspergillus niger In water at 37℃; for 3 h; Enzymatic reaction Reaction mixture (100 mL) comprising of 2.0725 g (1.5 mmol) tyrosol, 15.4 g cellobiose and Novozyme 188 (735 U of β-glucosidase) in distilled water was incubated at 37 °C. The reaction was stopped after 3 h by boiling in water bath for 5 min, centrifuged for 10 min at 4500 rpm and filtered through 0.22 m filter (25 mm diameter). The filtrate was applied on column of Sephadex LH-20 (75 cm long, 3.2 mm i.d.) equilibrated and eluted with distilled water. Tyrosol was regenerated by gradient of ethanol. The process of purification was monitored by TLC. Fractions containing salidroside were collected and concentrated in vacuo. To remove coloured substances originating from the enzyme, the material was further subjected to flash chromatography with gradient of methanol in chloroform. Fractions containing pure salidroside were concentrated and crystallised from mixture of methanol and chloroform (1:5, v/v).
Reference: [1] Letters in Organic Chemistry, 2009, vol. 6, # 2, p. 115 - 119
[2] Journal of Molecular Catalysis B: Enzymatic, 2015, vol. 113, p. 23 - 28
  • 5
  • [ 1346265-60-8 ]
  • [ 10338-51-9 ]
Reference: [1] Phytochemistry, 2011, vol. 72, # 17, p. 2244 - 2252
  • 6
  • [ 40661-45-8 ]
  • [ 10338-51-9 ]
  • [ 101489-37-6 ]
  • [ 123563-44-0 ]
Reference: [1] Tetrahedron, 1989, vol. 45, # 12, p. 3673 - 3682
  • 7
  • [ 67-56-1 ]
  • [ 40661-45-8 ]
  • [ 10338-51-9 ]
  • [ 101489-37-6 ]
  • [ 123563-44-0 ]
Reference: [1] Tetrahedron, 1989, vol. 45, # 12, p. 3673 - 3682
  • 8
  • [ 492-61-5 ]
  • [ 501-94-0 ]
  • [ 10338-51-9 ]
YieldReaction ConditionsOperation in experiment
24.3% With β-glycosidase from black plum seeds; 1-octyl-3-methylimidazolium hexafluorophosphate In 1,4-dioxane; aq. phosphate buffer at 50℃; for 72 h; Enzymatic reaction General procedure: The different seed meals were prepared as described by Yuet al. [10]. The reaction was performed in a 10 ml Erlenmeyershaking flask capped with a septum containing 1.6 ml dioxane, 0.4 ml phosphate buffer (pH 6.8, 100 mmol/L), 0.5 mmolD-glucose, 5 mmol tyrosol, and different fruit seed meal at 50°C and 200 r/min. Aliquots were withdrawn at specified timeintervals from the reaction mixture, and then diluted 50 timeswith the corresponding mobile phase prior to HPLC analysis.One unit of -glycosidase activity (U) was defined as theamount of enzyme required to produce 1 μmol salidroside inthe first hour under the above conditions. The specific activitiesof the black plum seed meal, apple seed meal, peach seed meal,bitter almond seed meal, and prune seed meal were 27.6, 23.4,25.9, 13.5, and 19.7 U/g.
Reference: [1] Chinese Journal of Catalysis, 2012, vol. 33, # 7-8, p. 1161 - 1165
[2] Journal of Molecular Catalysis B: Enzymatic, 2012, vol. 74, # 1-2, p. 24 - 28
  • 9
  • [ 501-94-0 ]
  • [ 153-18-4 ]
  • [ 10338-51-9 ]
Reference: [1] ChemSusChem, 2017, vol. 10, # 9, p. 2040 - 2045
  • 10
  • [ 50-99-7 ]
  • [ 501-94-0 ]
  • [ 10338-51-9 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 9, p. 2095 - 2097
  • 11
  • [ 501-94-0 ]
  • [ 10338-51-9 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 4, p. 581 - 586
[2] Phytochemistry, 1988, vol. 27, # 6, p. 1813 - 1816
[3] Tetrahedron, 1989, vol. 45, # 12, p. 3673 - 3682
[4] Synthetic Communications, 2011, vol. 41, # 17, p. 2594 - 2600
  • 12
  • [ 60037-43-6 ]
  • [ 10338-51-9 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 4, p. 581 - 586
[2] Synthetic Communications, 2011, vol. 41, # 17, p. 2594 - 2600
[3] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 524 - 530
  • 13
  • [ 572-09-8 ]
  • [ 10338-51-9 ]
Reference: [1] Phytochemistry, 1988, vol. 27, # 6, p. 1813 - 1816
[2] Tetrahedron, 1989, vol. 45, # 12, p. 3673 - 3682
  • 14
  • [ 1007587-13-4 ]
  • [ 10338-51-9 ]
Reference: [1] Chemistry of Natural Compounds, 2010, vol. 46, # 5, p. 701 - 703
  • 15
  • [ 501-94-0 ]
  • [ 2492-87-7 ]
  • [ 10338-51-9 ]
Reference: [1] Tetrahedron Asymmetry, 1999, vol. 10, # 12, p. 2429 - 2439
  • 16
  • [ 2280-44-6 ]
  • [ 501-94-0 ]
  • [ 10338-51-9 ]
Reference: [1] Asian Journal of Chemistry, 2013, vol. 25, # 9, p. 5095 - 5098
  • 17
  • [ 156-38-7 ]
  • [ 10338-51-9 ]
Reference: [1] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 524 - 530
[2] Patent: CN107880085, 2018, A,
  • 18
  • [ 38177-33-2 ]
  • [ 10338-51-9 ]
Reference: [1] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 524 - 530
  • 19
  • [ 83013-86-9 ]
  • [ 10338-51-9 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 6, p. 2061 - 2067
  • 20
  • [ 104-01-8 ]
  • [ 10338-51-9 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 4, p. 581 - 586
  • 21
  • [ 14199-15-6 ]
  • [ 10338-51-9 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 4, p. 581 - 586
  • 22
  • [ 58609-13-5 ]
  • [ 10338-51-9 ]
Reference: [1] Patent: CN107880085, 2018, A,
  • 23
  • [ 74808-10-9 ]
  • [ 10338-51-9 ]
Reference: [1] Patent: CN107880085, 2018, A,
  • 24
  • [ 61439-59-6 ]
  • [ 10338-51-9 ]
Reference: [1] Patent: CN107880085, 2018, A,
  • 25
  • [ 916458-79-2 ]
  • [ 10338-51-9 ]
Reference: [1] Patent: CN107880085, 2018, A,
  • 26
  • [ 492-61-5 ]
  • [ 10338-51-9 ]
Reference: [1] Biocatalysis and Biotransformation, 2018,
  • 27
  • [ 60037-43-6 ]
  • [ 604-69-3 ]
  • [ 10338-51-9 ]
Reference: [1] Patent: CN106674300, 2017, A,
  • 28
  • [ 501-94-0 ]
  • [ 5391-18-4 ]
  • [ 10338-51-9 ]
Reference: [1] Biocatalysis and Biotransformation, 2018,
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