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Chemical Structure| 103859-86-5 Chemical Structure| 103859-86-5

Structure of 103859-86-5

Chemical Structure| 103859-86-5

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Product Details of [ 103859-86-5 ]

CAS No. :103859-86-5
Formula : C11H13NO2
M.W : 191.23
SMILES Code : O=C1NCC(C2=CC=C(OC)C=C2)C1
MDL No. :MFCD00297168

Safety of [ 103859-86-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 103859-86-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 103859-86-5 ]

[ 103859-86-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 552331-00-7 ]
  • [ 103859-86-5 ]
  • C16H17N3O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 100℃; for 14h;Inert atmosphere; Example 20; bis(2,2,2-trichloroethyl)(4-(4-(4-methoxyphenyl)-2-oxopyrrolidin-1-yl)pyridin-2-yl)imidodicarbonateA solution of <strong>[552331-00-7]4-iodopyridin-2-amine</strong> (440 mg, 2 mmol), 4-(4-methoxyphenyl)pyrrolidin-2-one (459 mg, 2.4 mmol) obtained in Reference Example 8, potassium phosphate (552 mg, 4 mmol), copper iodide (76 mg, 0.4 mmol) and N,N'-dimethylethylenediamine (43 mul, 0.4 mmol) in dioxane (10 ml) was stirred at 100 C. for 14 hr under an argon atmosphere. Water was added to the mixture, and the mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous sodium hydrogensulfate. The solvent was evaporated under reduced pressure. To a solution of the obtained residue and triethylamine (0.35 ml, 4.8 mmol) in tetrahydrofuran (20 ml) was added 2,2,2-trichloroethyl chloroformate (0.6 ml, 4.4 mmol) at 0 C., and the mixture was stirred for 10 min. The mixture was diluted with water, and extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to give the title compound (100 mg, yield 15%) as a solid.1H-NMR (CDCl3) delta: 2.75-2.87 (1H, m), 2.98-3.10 (1H. m), 3.65-3.77 (1H, m), 3.77-3.85 (1H, m), 3.82 (3H, s), 4.19 (1H, dd, J=9.3, 8.0 Hz), 4.79-4.83 (4H, m), 6.91 (1H, d, J=8.5 Hz), 7.19 (1H, d, J=8.5 Hz), 7.70 (1H, dd, J=5.8, 1.6 Hz), 7.73 (1H, d, J=1.6 Hz), 8.47 (1H, d, J=5.8 Hz).
 

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