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Chemical Structure| 10410-35-2 Chemical Structure| 10410-35-2

Structure of 10410-35-2

Chemical Structure| 10410-35-2

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Product Details of [ 10410-35-2 ]

CAS No. :10410-35-2
Formula : C10H10O
M.W : 146.19
SMILES Code : CC1=CC=C(OC=C2C)C2=C1
MDL No. :MFCD13187930

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Application In Synthesis of [ 10410-35-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10410-35-2 ]

[ 10410-35-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6342-56-9 ]
  • [ 17429-02-6 ]
  • [ 10410-35-2 ]
YieldReaction ConditionsOperation in experiment
75% General procedure: To a solution of 4-hydroxy-1-cyclohexanone (8) (200 mg, 1.75 mmol) in dry CH2Cl2 (15 ml) at -35 C was added separately a solution of TiCl4 (0.29 ml, 2.62 mmol) and tributylamine (1.25 ml, 5.25 mmol) in CH2Cl2 (2 ml each). The reaction mixture was stirred at the same temperature for half an hour and after which a solution of 1,1-dimethoxyacetone (0.42 ml, 3.5 mmol) in CH2Cl2 (2 ml) was added to it. Reaction mixture was allowed to attain room temperature on its own and left to stir for 3 hours. Water (20 ml) was added to quench the reaction mixture. Extraction was done with CH2Cl2 (3 x 15 ml) and the combined organic layer was washed with brine (40 ml), dried over anhydrous Na2SO4 (2 g) and evaporated to dryness under reduced pressure. Crude product was purified with column chromatography using ethyl acetate/hexanes (5:95). The product was obtained as a colorless liquid in 78% yield (180 mg).
 

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