Select Region or Location
Americas
  • Argentina
  • Brazil
  • Canada
  • Mexico
  • United States
  • Other Americas
Europe
  • Austria
  • Belgium
  • Bulgaria
  • Croatia/Hrvatska
  • Cyprus
  • Czech Republic
  • Denmark
  • Estonia
  • Finland
  • France
  • Germany
  • Greece
  • Hungary
  • Ireland
  • Italy
  • Latvia
  • Liechtenstein
  • Lithuania
  • Luxembourg
  • Malta
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Romania
  • Slovak Republic
  • Slovenia
  • Spain
  • Sweden
  • Switzerland
  • Turkey
  • United Kingdom
  • Other Europe
Asia Pacific
  • Australia
  • China
  • India
  • Indonesia
  • Japan
  • Korea, Republic of
  • Malaysia
  • New Zealand
  • Philippines
  • Singapore
  • Thailand
  • Vietnam
  • Other Asia Pacific
Africa And Middle East
  • Egypt
  • Israel
  • Other Africa And Middle East
USD
Home Cart Sign in  
Chemical Structure| 10477-47-1 Chemical Structure| 10477-47-1

Structure of Propargyl acrylate
CAS No.: 10477-47-1

Chemical Structure| 10477-47-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock
{[ item.pr_size ]}{[ size_append_text(item.pr_size, proInfo.prAm, 'list') ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

  • {[ item.pr_size ]}
    {[ size_append_text(item.pr_size, proInfo.prAm, 'list') ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 10477-47-1 ]

CAS No. :10477-47-1
Formula : C6H6O2
M.W : 110.11
SMILES Code : O=C(OCC#C)C=C
English Name :Prop-2-yn-1-yl acrylate
MDL No. :MFCD00078451

Safety of [ 10477-47-1 ]

Application In Synthesis of [ 10477-47-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10477-47-1 ]

[ 10477-47-1 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 927816-03-3 ]
  • [ 10477-47-1 ]
  • [ 1027037-66-6 ]
YieldReaction ConditionsOperation in experiment
85% With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(I) bromide In N,N-dimethyl-formamide at 20℃; for 11h;
  • 2
  • [ 13733-78-3 ]
  • [ 10477-47-1 ]
  • [ 1166168-35-9 ]
YieldReaction ConditionsOperation in experiment
95% In N,N-dimethyl-formamide at 20℃; for 24h; 1 Propargyl acrylate (13 g, 0.118 mmoles), dodecyl azide (22.3 g, 0.118 mmoles) and tetrakis(acetonitrile)copper (I) hexafluorophosphate (0.75 g, 2 mmoles) are dissolved in DMF (200 ml) and stirred at room temperature under nitrogen for 24 hours. The reaction mixture is poured into water wherefrom the product precipitated as a white crystalline solid (33.5 g; yield 95%; mp 50-520C). 1H NMR (CDCI3, δ ppm) 7.78 (broad, 1 H), 6.42 (d, 1 H), 6.16 (dd, 1 H), 5.82 (d, 1 H), 5.30 (s, 2H), 4.32 (t, 2H), 1.92 (t, 2H), 1.28 (m, 20H), 0.88 (t, 3H). 13C NMR (CDCI3, δ ppm) 165.7, 142.4, 131.1 , 127.9, 123.5, 57.6, 57.5, 50.2, 31.7, 30.1 , 29.4, 29.3, 29.2, 29.1 , 28.8, 26.3, 22.4, 13.9.
  • 3
  • [ 83315-69-9 ]
  • [ 10477-47-1 ]
  • [ 1548801-84-8 ]
YieldReaction ConditionsOperation in experiment
93% With bromotris(triphenylphosphine)copper(I); triethylamine In tetrahydrofuran at 60℃; for 5h; Inert atmosphere; General reaction procedure for the click silylation General procedure: To a 50 ml two-necked round bottom flask with alkyne function (2 mmol), azide function (2 mmol/alkyne function), [CuBr(PPh3)3] (0.01 mmol/alkyne function), triethylamine (2 ml), and THF (2 ml) were added under nitrogen atmosphere and then the mixture was stirred at 60 °C for 5 h. The reaction mixture was allowed to cool, and the solvents were removed under vacuum followed by addition of hexane. The mixture was filtered and washed with 2×5 ml of hexane. The concentration of the filtrate under reduced pressure afforded the title compound in good to excellent yield.
93% With bromotris(triphenylphosphine)copper(I); triethylamine In tetrahydrofuran at 60℃; for 5h; Inert atmosphere; General reaction procedure for the click silylation: General procedure: To a 50 ml two-necked round bottom flask with alkyne function (2 mmol), azide function (2 mmol/alkyne function), [CuBr(PPh3)3] (0.01 mmol/alkyne function), triethylamine (2 ml),and THF (2 ml) were added under nitrogen atmosphere and then the mixture was stirred at 60 °C for 5 h. The reaction mixture was allowed to cool, and the solvents were removed under vacuum followed by addition of hexane. The mixture was filtered and washed with 2 Χ 5 ml of hexane. The concentration ofthe filtrate under reduced pressure afforded the title compound in good to excellent yield.
With bromotris(triphenylphosphine)copper(I); triethylamine In tetrahydrofuran at 60℃; for 5h; Inert atmosphere; General reaction procedure for the click silylation To a 50.0 ml two-necked round bottom flask with alkyne function (2 mmol), azide function (2 mmol/alkyne function), [CuBr(PPh3)3] (0.01 mmol/alkyne function), triethylamine (2.0 ml), and THF (2.0 ml) under nitrogen atmosphere and then the mixture was stirred at 60 °C for 5 h. The reaction mixture was allowed to cool, and the solvents were removed under vacuum followed by addition of hexane. The mixture was filtered and washed with 2 x 5.0 ml of hexane. The concentration of the filtrate under reduced pressure afforded the title compound in good to excellent yield.
  • 4
  • [ 10477-47-1 ]
  • [ 41505-84-4 ]
  • [ 1588498-17-2 ]
YieldReaction ConditionsOperation in experiment
75% With cesium fluoride In N,N-dimethyl-formamide at 110℃; for 2h; General procedure for the synthesis of compounds 3a-d: General procedure: General procedure for the synthesis of compounds 3a-d: A mixture of correspondingly substituted 2,3,4,5-tetrahydro-1Hpyrido[4,3-b]indole 1a-d (2 mmol), 0.22 g (2 mmol) acrylicacid propyn-2-yl ester (2) and 0.1 g (0.66 mmol) of CsF in1 mL of DMF was stirred at 110 °C during 2 h. The solvent was removed in vacuo (~3 mmHg) and the product was extracted from the residue with CH2Cl2. The solvent was removed in vacuo and the residue was purified by column chromatography (MeOH/CHCl3 1:5).
  • 5
  • [ 10477-47-1 ]
  • [ 99970-84-0 ]
  • C24H20N2O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With 1,4-diaza-bicyclo[2.2.2]octane; In methanol; at 20℃; for 12h; General procedure: To a flame-dried round bottle flask with a magnetic stirring bar were addedbipyridine aldehyde (0.001 mmol) 2 and (DABCO) as catalyst (10 mol%)) in methanol(4mL), followed by the addition of activated alkenes 4. The resulting mixture was stirred atroom temperature for 12 hours, after completion of the reaction (Monitored by TLC),solvents were removed in vacuo and the residue was purified on neutral alumina using 70%ethyl acetate in petroleum ether to afford the corresponding novel Morita-Baylis-Hillmanadduct of bipyridine 5 in very good yield.
  • 6
  • [ 10477-47-1 ]
  • [ 1835716-51-2 ]
  • [ 1835716-76-1 ]
YieldReaction ConditionsOperation in experiment
79% With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane; dichloromethane at 20℃; for 40h;
79% With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 20℃; for 40h; 25 Example 25 2-trifluoromethyl-methylthio-3- (4-nitro-phthalimide) - propionic acid propargyl N- trifluoromethylthio-4-nitro phthalimide (65.7mg, 0.225mmol), 1- propargyl acrylate (16.5mg, 0.15mmol), DABCO (8.75mg, 0.075mmol) and a mixed solution of methylene chloride and 1,4-dioxane: mixture (volume ratio 1 1,0.45mL) was stirred at room temperature for 40 hours.Concentrated under reduced pressure column chromatography to obtain the product isolated in 79% yield
  • 7
  • [ 10477-47-1 ]
  • [ 110448-29-8 ]
  • [ 2097616-13-0 ]
YieldReaction ConditionsOperation in experiment
62.9% With aluminum oxide; potassium fluoride In N,N-dimethyl-formamide at 20℃; Green chemistry; 4.1.2 Ethyl 3-(substituted)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (2a-j) General procedure: To a solution of DHPM (1) [31] (6.1g, 15mmol) and the appropriate substituted acrylate derivative (15mmol) in anhydrous DMF (30mL), KF/neutral alumina (10mol %) was added in one portion. The mixture was stirred at room temperature for 1-5 days. The completion of the reaction was monitored by TLC using 1:1 toluene: acetone. The catalyst was removed by filtration. The filtrate was then poured into ice-cold water (500mL). The obtained product was filtered, washed with water, dried and purified by crystallization or chromatography as specified under each compound.
  • 8
  • [ 10477-47-1 ]
  • [ 88321-09-9 ]
  • [ CAS Unavailable ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
1: 20 % 2: 7 % With 2-tert-butyl-1,1,3,3-tetramethylguanidine; scandium tris(trifluoromethanesulfonate) In dichloromethane at 40℃; Inert atmosphere;
  • 9
  • [ 182431-12-5 ]
  • [ 10477-47-1 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
75 % With 2-tert-butyl-1,1,3,3-tetramethylguanidine; scandium tris(trifluoromethanesulfonate) In dichloromethane at 40℃; Inert atmosphere;
  • 10
  • [ 59-89-2 ]
  • [ 10477-47-1 ]
  • [ 3047342-73-1 ]
YieldReaction ConditionsOperation in experiment
50 % With DABSO In dichloromethane at 20℃; Inert atmosphere; UV-irradiation;
 

Historical Records

Categories