Structure of Lomitapide
CAS No.: 182431-12-5
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Lomitapide is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.
Synonyms: AEGR-733; BMS-201038; AEGR 773
4.5
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| CAS No. : | 182431-12-5 |
| Formula : | C39H37F6N3O2 |
| M.W : | 693.72 |
| SMILES Code : | O=C(C1(CCCCN2CCC(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)CC2)C5=C(C6=C1C=CC=C6)C=CC=C5)NCC(F)(F)F |
| Synonyms : |
AEGR-733; BMS-201038; AEGR 773
|
| MDL No. : | MFCD16620494 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H302-H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT00474240 | Hypercholesterolemia | Phase 2 | Completed | - | United States, Alabama ... More >> Medical Affiliated Research Center Huntsville, Alabama, United States, 35801 United States, Florida Jacksonville Center for Clinical research Jacksonville, Florida, United States, 32205 Jacksonville Center For Clinical Research Jacksonville, Florida, United States, 32216 Renstar Medical Research Ocala, Florida, United States, 34471 United States, Georgia North Georgia Clinical Research Woodstock, Georgia, United States, 30189 United States, Illinois Radiant Research Chicago, Illinois, United States, 60610 United States, Indiana Medsphere Medical Research Center Evansville, Indiana, United States, 47714 Midwest Institute for Clinical Research Indianapolis, Indiana, United States, 46260 United States, Maine Maine Research Associates Auburn, Maine, United States, 04210 United States, Maryland Health Trends Research Baltimore, Maryland, United States, 21209 United States, North Carolina Piedmont Medical Research Associates Winston-Salem, North Carolina, United States, 27103 United States, Ohio Sterling Research Group Cincinnati, Ohio, United States, 45246 United States, South Carolina Coastal Carolina Research Center Goose Creek, South Carolina, United States, 29445 United States, Texas Dallas Diabetes and Endocrine Center Dallas, Texas, United States, 75230 Diabetes and Glandular Disease Research Dallas, Texas, United States, 78229 United States, Virginia Hampton Roads Center for Clinical Research Norfolk, Virginia, United States, 23502 National Clinical Research Richmond, Virginia, United States, 23294 Less << |
| NCT00474240 | - | Completed | - | - | |
| NCT00559962 | - | Completed | - | - | |
| NCT00359281 | Healthy | Phase 2 | Completed | - | United States, Pennsylvania ... More >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
| NCT00559962 | Hyperlipidemia | Phase 2 | Completed | - | United States, California ... More >> Scripps Clinic San Diego, California, United States, 92128 Radiant Research Santa Rosa, California, United States, 95405 United States, District of Columbia MedStar Research Institute Washington, District of Columbia, United States, 20003 United States, Illinois Radiant Research Chicago, Illinois, United States, 60610 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Kentucky LMARC Louisville, Kentucky, United States, 40213 United States, Maine Maine Research Associates Auburn, Maine, United States, 04210 United States, Maryland Health Trends Research Baltimore, Maryland, United States, 21209 Johns Hopkins Baltimore, Maryland, United States, 21287 United States, Missouri Washington Univ. School of Medicine Saint Louis, Missouri, United States, 63110 United States, Ohio Sterling Research Group Cincinnati, Ohio, United States, 45219 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Clinical Trial Network Houston, Texas, United States, 77074 dgd Research San Antonio, Texas, United States, 78229 Less << |
| NCT00405067 | Hypercholesterolemia | Phase 2 | Completed | - | United States, New Jersey ... More >> Pharmanet, Inc Princeton, New Jersey, United States, 08540-6242 Less << |
| NCT00405067 | - | Completed | - | - | |
| NCT00690443 | - | Completed | - | - | |
| NCT00690443 | Hypercholesterolemia | Phase 2 | Completed | - | United States, Florida ... More >> Linda Murray, DO - Radiant Research Pinellas Park, Florida, United States, 33781 United States, Minnesota Sheila Rodstein, MD Edina, Minnesota, United States, 55435 United States, Ohio Dennis McCluskey, MD - Radiant Research Mogadore, Ohio, United States, 44260 United States, Texas Michele Reynolds, MD Dallas, Texas, United States, 75231 William Jennings, MD - Radiant Research San Antonio, Texas, United States, 78229 Less << |
| NCT00730236 | Homozygous Familial Hyperchole... More >>sterolemia Less << | PHASE3 | COMPLETED | 2025-10-11 | Cedars-Sinai Medical Center, L... More >>os Angeles, California, 90048, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Robarts Research Institute, London, Ontario, N6A 5K8, Canada|Lipid Clinic and University of Montreal Community Genomic Medicine Center, Chicoutimi, Quebec, G7H 5H6, Canada|Dipartimento di Medicina Clinica e Della Patalogie Emergenti, Palermo, Sicily, Italy|Medicina Interna Universitaria, Ferrara, Italy|Centro Universitario Dislipidemie, Milano, Italy|Dipartimento di Clinica e Terapia Medica, Roma, Italy|Cardiology Research, Bloemfontein, 9300, South Africa|University of Capetown, Cape town, 7925, South Africa Less << |
| NCT00730236 | Homozygous Familial Hyperchole... More >>sterolemia Less << | PHASE3 | COMPLETED | 2025-10-11 | Cedars-Sinai Medical Center, L... More >>os Angeles, California, 90048, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Robarts Research Institute, London, Ontario, N6A 5K8, Canada|Lipid Clinic and University of Montreal Community Genomic Medicine Center, Chicoutimi, Quebec, G7H 5H6, Canada|Dipartimento di Medicina Clinica e Della Patalogie Emergenti, Palermo, Sicily, Italy|Medicina Interna Universitaria, Ferrara, Italy|Centro Universitario Dislipidemie, Milano, Italy|Dipartimento di Clinica e Terapia Medica, Roma, Italy|Cardiology Research, Bloemfontein, 9300, South Africa|University of Capetown, Cape town, 7925, South Africa Less << |
| NCT01760187 | Healthy Volunteer | Phase 1 | Completed | - | United Kingdom ... More >> Richmond Pharmacology Ltd Croydon, Surrey, United Kingdom, CR7 7YE Less << |
| NCT01556906 | Homozygous Familial Hyperchole... More >>sterolemia Less << | PHASE2 | COMPLETED | 2025-02-04 | University of Pennsylvania, Ph... More >>iladelphia, Pennsylvania, 19104, United States Less << |
| NCT01556906 | Homozygous Familial Hyperchole... More >>sterolemia Less << | PHASE2 | COMPLETED | 2025-02-04 | University of Pennsylvania, Ph... More >>iladelphia, Pennsylvania, 19104, United States Less << |
| NCT01915771 | Intra-subject Variability of P... More >>harmacokinetics Less << | Phase 1 | Completed | - | United Kingdom ... More >> Richmond Pharmacology Croydon, Surrey, United Kingdom, CR7 7YE Less << |
| NCT02399839 | - | Enrolling by invitation | March 2028 | - | |
| NCT00359281 | - | Completed | - | - | |
| NCT02080468 | Healthy | Phase 1 | Completed | - | United States, Texas ... More >> Covance Clinical Research Unit, Inc Dallas, Texas, United States, 75247 Less << |
| NCT00943306 | Familial Hypercholesterolemia | Phase 3 | Completed | - | United States, California ... More >> Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Canada, Ontario Robarts Research Institute London, Ontario, Canada, N6A 5K8 Canada, Quebec Lipid Clinic and University of Montreal Community Genomic Medicine Center Chicoutimi, Quebec, Canada, G7H 5H6 Italy Medicina Interna Universitaria Ferrara, Sicily, Italy Dipartimento di Medicina Clinica e Delle Patologie Emergenti Palermo, Sicily, Italy Centro Universitario Dislipidemie Milano, Italy DAI Ematologia, Oncologia, Anatomia Patologica e Medicina Roma, Italy South Africa Cardiology Research Bloemfontein, South Africa, 9300 University of Capetown Cape town, South Africa, 7925 Less << |
| NCT00943306 | - | Completed | - | - | |
| NCT02135705 | Homozygous Familial Hyperchole... More >>sterolemia Less << | RECRUITING | 2028-09-01 | Brookwood Baptist Medical Cent... More >>er, Birmingham, Alabama, 35209, United States|Springhill Physician Practices, Mobile, Alabama, 36608, United States|Northern Arizona Healthcare, Cottonwood, Arizona, 86326, United States|One Medical, Gilbert, Arizona, 85296, United States|Scottsdale Family Health, Phoenix, Arizona, 85018, United States|Pima Heart, Tucson, Arizona, 85718, United States|Arkansas Heart Center, Fort Smith, Arkansas, 72901, United States|Cedars-Sinai Medical Center, Los Angeles, California, 90048, United States|University of Colorado Health, Aurora, Colorado, 80045, United States|Alfieri Cardiology, Newark, Delaware, 19713, United States|Preventative Cardiology, Inc., Boca Raton, Florida, 33434, United States|Florida Lipid Institute, Winter Park, Florida, 32792-2223, United States|Piedmont Heart Institute, Atlanta, Georgia, 30309, United States|Atlanta Heart Specialists, Cumming, Georgia, 30041, United States|Northside Hospital, Inc., Cumming, Georgia, 30041, United States|Comprehensive Cardiovascular Care, Gurnee, Illinois, 60031, United States|Community Health Network, Indianapolis, Indiana, 46250, United States|St. Vincent Medical Group, Inc., Indianapolis, Indiana, 46290, United States|Henry County Medical Center, New Castle, Kentucky, 40050, United States|Cardiovascular Institute of the South, Houma, Louisiana, 70360, United States|Get Well Immediate Care, Towson, Maryland, 21204, United States|University of Michigan Health System, Ann Arbor, Michigan, 48109, United States|Complete Family Care Cholesterol Treatment Center, Sterling Heights, Michigan, 48314, United States|Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, 55407, United States|HealthEast Care System, Saint Paul, Minnesota, 55102, United States|Stern Cardiovascular Foundation, Southaven, Mississippi, 38671, United States|Methodist Physicians Clinic, Omaha, Nebraska, 68114, United States|Hackensack Meridian Health, Edison, New Jersey, 08817, United States|Avinash C. Gupta, MD, PC, Lakewood, New Jersey, 08701, United States|201 Route 17 North, Rutherford, New Jersey, 07070, United States|Valley Medical Group, Wyckoff, New Jersey, 07481, United States|Murray Hill Medical Group, New York, New York, 10016, United States|NY Heart Center, Syracuse, New York, 13210, United States|Pediatric Cardiology Associates, Syracuse, New York, 13210, United States|Cardiology Specialists of the Carolinas PA, Charlotte, North Carolina, 28204, United States|Cardiology Specialists Of Carolina, Charlotte, North Carolina, 28211, United States|The Heart Care Group, PC, Allentown, Pennsylvania, 18103, United States|St. Luke's University Health Network - Pennsylvania, Bethlehem, Pennsylvania, 18015, United States|Lehigh Valley Hospital And Health Network, East Stroudsburg, Pennsylvania, 18301, United States|Cardiology Consultants of Philadelphia, Philadelphia, Pennsylvania, 19107, United States|Thomas Jefferson University Health System, Philadelphia, Pennsylvania, 19148, United States|Palmetto Health, Columbia, South Carolina, 29203, United States|317 Saint Francis Dr., Greenville, South Carolina, 29601, United States|Cardiovascular Specialists of Texas, Austin, Texas, 78758, United States|Baylor Scott & White Health, Dallas, Texas, 75226, United States|The University of Vermont Health Network, Burlington, Vermont, 05401-1473, United States|West Virginia University Medicine, Morgantown, West Virginia, 26506, United States|Ascension, Milwaukee, Wisconsin, 53211, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Aspirus Research Institute, Wausau, Wisconsin, 54401, United States|Clinica de Salud de Chaco, Reconquista, Chaco CPA, H3500BJS, Argentina|Nova Scotia Health Authority, Halifax, Nova Scotia, B3H2Y9, Canada|Robarts Research Institute, London, Ontario, N6A5B7, Canada|Ecogene-21, Chicoutimi, Quebec, G7H7K9, Canada|McGill University, Montréal, Quebec, H4A3J1, Canada|Centre Hospitalier Régional Universitaire de Lille, Lille, Cedex, 59037, France|Centre Hospitalier Universitaire Lyon, Bron, Lyon, 69677, France|Centre Hospitalier Universitaire Strasbourg, Strasbourg, 67000, France|University General Hospital of Ioannina, Ioánnina, 45500, Greece|Metropolitan Hospital, Piraeus, 18547, Greece|Policlinico S. Orsola-Malpighi, Bologna, BO, 40138, Italy|Azienda Ospedaliera G. Brotzu, Cagliari, CA, 09134, Italy|ASST Grande Ospedale Metropolitano Niguarda, Milano, MI, 20162, Italy|Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo, PA, 90127, Italy|Azienda Ospedaliera Universita di Padova, Padova, PD, 35128, Italy|Università degli Studi di Roma La Sapienza, Roma, RM, 00161, Italy|Università degli Studi di Roma La Sapienza, Roma, Rome, 00161, Italy|Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano, TO, 10043, Italy|Azienda Ospedaliero Universi consorziale policlinico di Bari, Bari, 70120, Italy|Azienda Ospedaliera Specialistica Dei Colli, Napoli, 80131, Italy|Azienda Ospedaliera Universitaria Federico II, Napoli, 80131, Italy|CNR Regione Toscana - Fondazione Toscana Gabriele Monasterio, Pisa, 56124, Italy|Radboud Universiteit Medisch Centrum, Nijmegen, Gelderland, 6525 GA, Netherlands|Erasmus Medisch Centrum, Rotterdam, Zuid Holland, 3015 GD, Netherlands|Imperial College Healthcare - NHS Trust, London, W12 0NN, United Kingdom Less << | |
| NCT02765841 | Homozygous Familial Hyperchole... More >>sterolemia Less << | PHASE3 | WITHDRAWN | 2025-12-19 | - |
| NCT02044419 | Healthy | Phase 1 | Completed | - | United Kingdom ... More >> Richmond Pharmacology Ltd Croydon, Surrey, United Kingdom, CR7 7YE Less << |
| NCT02044419 | - | Completed | - | - | |
| NCT02399852 | Homozygous Familial Hyperchole... More >>sterolemia Less << | WITHDRAWN | 2025-12-21 | - | |
| NCT01760187 | - | Completed | - | - | |
| NCT02080455 | Effect of Atorvastatin on the ... More >>Pharmacokinetics of Lomitapide Less << | Phase 1 | Completed | - | United States, Texas ... More >> Covance Clinical Research Unit, Inc Dallas, Texas, United States, 75247 Less << |
| NCT02173158 | - | Completed | - | - | |
| NCT02173158 | Familial Hypercholesterolemia ... More >>- Homozygous Less << | Phase 3 | Completed | - | Japan ... More >> Kurume-shi, Fukuoka, Japan, 830-8522 Kanazawa, Ishikawa, Japan, 920-8641 Osakashi, Osaka, Japan, 530-00001 Suita-shi, Osaka, Japan, 565-8565 Tokorozawa, Saitama, Japan, 359-1142 Bunkyo-ku, Tokyo, Japan, 113-8519 Less << |
| NCT04681170 | Homozygous Familial Hyperchole... More >>sterolaemia (HoFH) Less << | PHASE3 | COMPLETED | 2024-06-06 | Universtiats-Kinderlinik Heide... More >>lberg, Heidelberg, Baden-Wurttemberg, 69120, Germany|University Hospital of Cologne, Cologne, 50937, Germany|University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany|Chaim Sheba Medical Center, Ramat Gan,, 52621, Israel|U.O.C. Clinica Medica 1, Padova, Padua, 35128, Italy|Bambino Gesù Children's Hospital,, Roma, 00165, Italy|King Abdullah International Medical Research Centre (KAIMRC),, Riyadh, Saudi Arabia|King Faisal Specialist Hospital, Riyadh, Saudi Arabia|Hospital Universitari Sant Joan, Reus, Tarragona,, 43204, Spain|Hospital Abente y Lago, A Coru?a, 15006, Spain|Hospital Clinico Universitario of Valencia, Valencia, 46010, Spain|E.P.S. Fattouma Bourguiba Hospital, Monastir,, 5000, Tunisia Less << |
Tags: Lomitapide | AEGR-733 | Others | MTTP | Other Inhibitors/Agonists | Small Molecule Positive Drugs | Steroids | Biological Buffers | Fluorescence Labeling Reagents | Fluorescent Dyes | Structure | 182431-12-5
Precautionary Statements-General | |
| Code | Phrase |
| P101 | If medical advice is needed,have product container or label at hand. |
| P102 | Keep out of reach of children. |
| P103 | Read label before use |
Prevention | |
| Code | Phrase |
| P201 | Obtain special instructions before use. |
| P202 | Do not handle until all safety precautions have been read and understood. |
| P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
| P211 | Do not spray on an open flame or other ignition source. |
| P220 | Keep/Store away from clothing/combustible materials. |
| P221 | Take any precaution to avoid mixing with combustibles |
| P222 | Do not allow contact with air. |
| P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
| P230 | Keep wetted |
| P231 | Handle under inert gas. |
| P232 | Protect from moisture. |
| P233 | Keep container tightly closed. |
| P234 | Keep only in original container. |
| P235 | Keep cool |
| P240 | Ground/bond container and receiving equipment. |
| P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
| P242 | Use only non-sparking tools. |
| P243 | Take precautionary measures against static discharge. |
| P244 | Keep reduction valves free from grease and oil. |
| P250 | Do not subject to grinding/shock/friction. |
| P251 | Pressurized container: Do not pierce or burn, even after use. |
| P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
| P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
| P262 | Do not get in eyes, on skin, or on clothing. |
| P263 | Avoid contact during pregnancy/while nursing. |
| P264 | Wash hands thoroughly after handling. |
| P265 | Wash skin thouroughly after handling. |
| P270 | Do not eat, drink or smoke when using this product. |
| P271 | Use only outdoors or in a well-ventilated area. |
| P272 | Contaminated work clothing should not be allowed out of the workplace. |
| P273 | Avoid release to the environment. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
| P281 | Use personal protective equipment as required. |
| P282 | Wear cold insulating gloves/face shield/eye protection. |
| P283 | Wear fire/flame resistant/retardant clothing. |
| P284 | Wear respiratory protection. |
| P285 | In case of inadequate ventilation wear respiratory protection. |
| P231 + P232 | Handle under inert gas. Protect from moisture. |
| P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
| Code | Phrase |
| P301 | IF SWALLOWED: |
| P304 | IF INHALED: |
| P305 | IF IN EYES: |
| P306 | IF ON CLOTHING: |
| P307 | IF exposed: |
| P308 | IF exposed or concerned: |
| P309 | IF exposed or if you feel unwell: |
| P310 | Immediately call a POISON CENTER or doctor/physician. |
| P311 | Call a POISON CENTER or doctor/physician. |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
| P313 | Get medical advice/attention. |
| P314 | Get medical advice/attention if you feel unwell. |
| P315 | Get immediate medical advice/attention. |
| P320 | |
| P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
| P321 | |
| P322 | |
| P330 | Rinse mouth. |
| P331 | Do NOT induce vomiting. |
| P332 | IF SKIN irritation occurs: |
| P333 | If skin irritation or rash occurs: |
| P334 | Immerse in cool water/wrap n wet bandages. |
| P335 | Brush off loose particles from skin. |
| P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
| P337 | If eye irritation persists: |
| P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
| P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P342 | If experiencing respiratory symptoms: |
| P350 | Gently wash with plenty of soap and water. |
| P351 | Rinse cautiously with water for several minutes. |
| P352 | Wash with plenty of soap and water. |
| P353 | Rinse skin with water/shower. |
| P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
| P361 | Remove/Take off immediately all contaminated clothing. |
| P362 | Take off contaminated clothing and wash before reuse. |
| P363 | Wash contaminated clothing before reuse. |
| P370 | In case of fire: |
| P371 | In case of major fire and large quantities: |
| P372 | Explosion risk in case of fire. |
| P373 | DO NOT fight fire when fire reaches explosives. |
| P374 | Fight fire with normal precautions from a reasonable distance. |
| P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
| P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
| P378 | |
| P380 | Evacuate area. |
| P381 | Eliminate all ignition sources if safe to do so. |
| P390 | Absorb spillage to prevent material damage. |
| P391 | Collect spillage. Hazardous to the aquatic environment |
| P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
| P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
| P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
| P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
| P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
| P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
| P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
| P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
| P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
| P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
| P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
| P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
| P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
| P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
| P370 + P376 | In case of fire: Stop leak if safe to Do so. |
| P370 + P378 | In case of fire: |
| P370 + P380 | In case of fire: Evacuate area. |
| P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
| P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
| Code | Phrase |
| P401 | |
| P402 | Store in a dry place. |
| P403 | Store in a well-ventilated place. |
| P404 | Store in a closed container. |
| P405 | Store locked up. |
| P406 | Store in corrosive resistant/ container with a resistant inner liner. |
| P407 | Maintain air gap between stacks/pallets. |
| P410 | Protect from sunlight. |
| P411 | |
| P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
| P413 | |
| P420 | Store away from other materials. |
| P422 | |
| P402 + P404 | Store in a dry place. Store in a closed container. |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
| P403 + P235 | Store in a well-ventilated place. Keep cool. |
| P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
| P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
| P411 + P235 | Keep cool. |
Disposal | |
| Code | Phrase |
| P501 | Dispose of contents/container to ... |
| P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
| Code | Phrase |
| H200 | Unstable explosive |
| H201 | Explosive; mass explosion hazard |
| H202 | Explosive; severe projection hazard |
| H203 | Explosive; fire, blast or projection hazard |
| H204 | Fire or projection hazard |
| H205 | May mass explode in fire |
| H220 | Extremely flammable gas |
| H221 | Flammable gas |
| H222 | Extremely flammable aerosol |
| H223 | Flammable aerosol |
| H224 | Extremely flammable liquid and vapour |
| H225 | Highly flammable liquid and vapour |
| H226 | Flammable liquid and vapour |
| H227 | Combustible liquid |
| H228 | Flammable solid |
| H229 | Pressurized container: may burst if heated |
| H230 | May react explosively even in the absence of air |
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
| H240 | Heating may cause an explosion |
| H241 | Heating may cause a fire or explosion |
| H242 | Heating may cause a fire |
| H250 | Catches fire spontaneously if exposed to air |
| H251 | Self-heating; may catch fire |
| H252 | Self-heating in large quantities; may catch fire |
| H260 | In contact with water releases flammable gases which may ignite spontaneously |
| H261 | In contact with water releases flammable gas |
| H270 | May cause or intensify fire; oxidizer |
| H271 | May cause fire or explosion; strong oxidizer |
| H272 | May intensify fire; oxidizer |
| H280 | Contains gas under pressure; may explode if heated |
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
| H290 | May be corrosive to metals |
Health hazards | |
| Code | Phrase |
| H300 | Fatal if swallowed |
| H301 | Toxic if swallowed |
| H302 | Harmful if swallowed |
| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
| H310 | Fatal in contact with skin |
| H311 | Toxic in contact with skin |
| H312 | Harmful in contact with skin |
| H313 | May be harmful in contact with skin |
| H314 | Causes severe skin burns and eye damage |
| H315 | Causes skin irritation |
| H316 | Causes mild skin irritation |
| H317 | May cause an allergic skin reaction |
| H318 | Causes serious eye damage |
| H319 | Causes serious eye irritation |
| H320 | Causes eye irritation |
| H330 | Fatal if inhaled |
| H331 | Toxic if inhaled |
| H332 | Harmful if inhaled |
| H333 | May be harmful if inhaled |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| H335 | May cause respiratory irritation |
| H336 | May cause drowsiness or dizziness |
| H340 | May cause genetic defects |
| H341 | Suspected of causing genetic defects |
| H350 | May cause cancer |
| H351 | Suspected of causing cancer |
| H360 | May damage fertility or the unborn child |
| H361 | Suspected of damaging fertility or the unborn child |
| H361d | Suspected of damaging the unborn child |
| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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