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Chemical Structure| 1051314-31-8 Chemical Structure| 1051314-31-8

Structure of 1051314-31-8

Chemical Structure| 1051314-31-8

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Product Details of [ 1051314-31-8 ]

CAS No. :1051314-31-8
Formula : C17H15BrN2O3
M.W : 375.22
SMILES Code : O=C1C=CC(Br)=CN1CCOC2=CC=NC3=CC(OC)=CC=C23
MDL No. :N/A

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Application In Synthesis of [ 1051314-31-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1051314-31-8 ]

[ 1051314-31-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 68500-37-8 ]
  • [ 1051315-77-5 ]
  • [ 1051314-31-8 ]
YieldReaction ConditionsOperation in experiment
5-Bromo-l-(2-(7-methoxyquinolin-4-yloxy)ethyl)pyridin-2(lH)-one: To a stirring solution of 5-bromo-l-(2-hydroxyethyl)pyridin-2(lH)-one (3000 mg, 13.7 mmol) in DMF (25 mL) was added sodium hydride (60percent dispersion in mineral oil, 632.6 mg, 27.5 mumol) portionwise. After stirred for 30 min at 23°C, additional DMF (20 mL) was added to the thick suspension. To this was added 4- chloro-7-methoxyquinoline (2664 mg, 13.7 mmol). Upon completion, the reaction was quenched with 5percent NaHCO3 (100 mL), and the aqueous was extracted with CH2Cl2 (4x75 mL). The combined organics were dried over MgSO4, concentrated from toluene, and purified on 80 grams of silica eluting with 30-80percent of 5percent MeOH/ CH2Cl2. The product was isolated as a white solid. MS (ESI pos. ion) m/z (MH+): 375/377. Calc'd exact mass for Ci7Hi5BrN2O3: 374. 13C NMR (101 MHz, CDCl3) delta ppm 48.66, 54.80, 64.75, 97.11, 98.75, 106.69, 114.92, 118.10, 121.48, 121.78, 137.81, 142.38, 150.57, 151.00, 159.87, 160.24, 160.40
 

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