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Chemical Structure| 105496-31-9 Chemical Structure| 105496-31-9

Structure of Fmoc-Glycinol
CAS No.: 105496-31-9

Chemical Structure| 105496-31-9

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Product Details of [ 105496-31-9 ]

CAS No. :105496-31-9
Formula : C17H17NO3
M.W : 283.32
SMILES Code : O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCO
MDL No. :MFCD00235927
InChI Key :XLIFWDZVNRWYKV-UHFFFAOYSA-N
Pubchem ID :2817739

Safety of [ 105496-31-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 105496-31-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 105496-31-9 ]

[ 105496-31-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2002-24-6 ]
  • [ 82911-69-1 ]
  • [ 105496-31-9 ]
YieldReaction ConditionsOperation in experiment
64% With potassium carbonate; In water; acetonitrile; at 20℃; for 0.5h;Product distribution / selectivity; Example 12 Synthesis of 2: 1.44 Grams (0.015 Moles) of the HCl salt of 2-aminoethanol (1), 5.0 grams (0.018 Moles) of Fmoc-succinimide (2) were dissolved in 20 mL of acetonitrile and 20 mL of 10% aqueous potassium carbonate solution in a round bottom flask and stirred at room temperature for 30 minutes. The reaction was quenched with a 10% citric acid solution and concentrated to remove the acetonitrile. The aqueous layer was extracted 3 times with 30 mL of ethyl acetate and the organic layer was washed with brine twice with 20 mL. Although the compound was pure enough it was purified over silica gel with 2-5% MeOH in DCM to give 2.5 grams of 2 in 64% yield.
 

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