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Chemical Structure| 1059191-44-4 Chemical Structure| 1059191-44-4

Structure of 1059191-44-4

Chemical Structure| 1059191-44-4

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Product Details of [ 1059191-44-4 ]

CAS No. :1059191-44-4
Formula : C8H5ClF3N3S
M.W : 267.66
SMILES Code : FC(C1=CN2C(SC)=NC(Cl)=CC2=N1)(F)F

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Application In Synthesis of [ 1059191-44-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1059191-44-4 ]

[ 1059191-44-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 431-37-8 ]
  • [ 1005-38-5 ]
  • [ 1059191-44-4 ]
YieldReaction ConditionsOperation in experiment
45% In N,N-dimethyl-formamide; at 120℃; for 16h; Example 21A; 7-Chloro-5-(methylthio)-2-(trifluoromethyl)imidazo[1,2-c]pyrimidine 5 g (28.5 mmol) of 6-chloro-2-(methylthio)pyrimidine-4-amine and 6.26 g (42.7 mmol) of 3-chloro-1,1,1-trifluoropropanone are dissolved in 200 ml of DMF and heated at 120° C. for 16 h. After the reaction is complete, water is added and the mixture is extracted three times with ethyl acetate. The combined organic phases are dried over sodium sulphate and the product is purified by silica gel chromatography. Drying under high vacuum results in 3.5 g (45percent of theory) of the product as a solid.LCMS (method 5): Rt=3.40 min. (m/z=268 (M+H)+)1H-NMR (400 MHz, DMSO-d6): delta=8.65 (s, 1H), 7.75 (s, 1H), 2.78 (s, 3H).
 

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