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CAS No. : | 1068-52-6 | MDL No. : | MFCD01311832 |
Formula : | C2H2BrNaO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | SESSOVUNEZQNBV-UHFFFAOYSA-M |
M.W : | 160.93 | Pubchem ID : | 23675628 |
Synonyms : |
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P405-P501 | UN#: | 2811 |
Hazard Statements: | H301-H315-H319-H335 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With thionyl chloride; Petroleum ether |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ethanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride THF; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | In tetrahydrofuran for 35h; Heating; | |
With sodium hydride 1) THF, 0-25 deg C, 2) reflux; Yield given. Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride 1.) DMF, RT, 2.) DMF, 80 deg C, 12 h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride 1.) DMF, RT, 2.) DMF, 80 deg C, 12 h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride 1.) DMF, RT, 2.) DMF, 80 deg C, 12 h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium 1.) from 90 deg C to 100 deg C, 2.) from 80 deg C to 90 deg C, 5h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium 1.) from 90 deg C to 100 deg C, 2.) from 80 deg C to 90 deg C, 5h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium 1.) from 90 deg C to 100 deg C, 2.) from 80 deg C to 90 deg C, 5h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride 1.) DMF, RT, 2.) DMF, 80 deg C, 12 h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | In tetrahydrofuran at 0℃; for 37h; Heating; | |
With sodium hydride 1) THF, 0-25 deg C, 2) reflux; Yield given. Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium <i>tert</i>-butylate 1.) THF, 0.5 h, 2.) DMF, RT, 15 h; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | In 1,2-dimethoxyethane for 0.5h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With 9-borabicyclo[3.3.1]nonane dimer In tetrahydrofuran for 1h; Ambient temperature; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | In water for 3h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With sodium hydroxide In ethanol at 40 - 42℃; for 7h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With silver nitrate In ethanol at 0℃; for 4h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With Tris(3,6-dioxaheptyl)amine; sodium hydride; sodium iodide In tetrahydrofuran for 4h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | With sodium hydroxide; hydrogen bromide In water at 35℃; for 24h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pH=10 In water |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride 1.) THF, a) 0 deg C, 15 min, b) from 0 deg C to 25 deg C, 15 min, 2.) THF, 25 deg C, 3 h; Yield given; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride 1.) THF, a) 0 deg C, 15 min, b) from 0 deg C to 25 deg C, 15 min, 2.) THF, 25 deg C, 3 h; Yield given; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride 1.) THF, a) 0 deg C, 15 min, b) from 0 deg C to 25 deg C, 15 min, 2.) THF, 25 deg C, 3 h; Yield given; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ethanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With water at 100℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 130℃; for 23h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54% | Stage #1: Nerol With sodium hydride In N,N-dimethyl-formamide at 30℃; for 1h; Stage #2: sodium 2-bromoacetate In N,N-dimethyl-formamide for 12h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | Stage #1: Geraniol With sodium hydride In N,N-dimethyl-formamide at 30℃; for 1h; Stage #2: sodium 2-bromoacetate In N,N-dimethyl-formamide for 12h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | Stage #1: biphenyl-4-yl methanol With sodium hydride In N,N-dimethyl-formamide at 30℃; for 1h; Stage #2: sodium 2-bromoacetate In N,N-dimethyl-formamide for 12h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With sodium hydride at 20℃; for 8h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
41.5% | Stage #1: methyliodoarsine With sodium hydroxide at 0℃; for 0.25h; Stage #2: sodium 2-bromoacetate With sodium hydroxide In water at 0 - 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34% | Stage #1: 3A,6A,-3B,6B-3C,6C-3D,6D-3E,6E-3F,6F-Hexaanhydro-α-cyclodextrin With sodium hydride In N,N-dimethyl-formamide for 0.583333h; Stage #2: sodium 2-bromoacetate In N,N-dimethyl-formamide for 3h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With sodium hydroxide In water at 4℃; for 24h; | Hyaluronan (6.0 g) was dissolved in 600 mL distilled water (1% w/v solution). The pH of the solution was adjusted to 9.0 by adding 1 M NaOH. Bromoacetic anhydride (40 g, 153 mmol) was then added dropwise to the solution and the reaction was stirred for 24 h at 4° C. This amount of bromoacetic anhydride corresponds to 10 equivalents relative to the number of primary C-6 hydroxyl groups of the N-acetylglucosamine residues. The reaction mixture was then dialyzed (MWCO 10000) for 3 days against distilled water. The sample was then lyophilized and analyzed. The purity of the sample was determined by 1H-NMR and GPC and the degree of substitution (SD) was determined derivatization with SAMSA fluorescein (SD18%). 1H-NMR (D2O); chemical shift corresponding to the substituent: δ=3.84 ppm (COCH2Br). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride In tetrahydrofuran |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride In tetrahydrofuran; <i>N</i>-methyl-acetamide | 38 EXAMPLE 38 To a solution of 4.17 g (13.8 mmol) of 5-hydroxy-8-(3-pyridyl)-1-(2-tetrahydropyranyloxy)-octane (example 37) in 30 ml dry dimethylformamide is added 17 ml (27.6 mmol) of a 1.61M solution of potassium t-butoxide in tetrahydrofuran and the resulting red solution is stirred for 0.5 h. Then the mixture is cooled to 10° and 4.9 g (30.4 mmol) of sodium bromoacetate is added followed by 40 ml dry dimethylformamide, and the reaction mixture is stirred at room temperature for 18 h. The reaction mixture is diluted with ether and water. The ether layer is separated and the aqueous phase is adjusted to pH=6.5 using 1N aqueous hydrochloric acid. The resulting solution is extracted thrice with ethyl acetate. The aqueous phase is again adjusted to pH=6.5 and extracted again. The combined organic phase is washed with brine, dried, filtered, and concentrated to give 8-hydroxy-4-[3-(3-pyridyl)propyl]-3-oxa-octanoic acid. | |
With hydrogenchloride In tetrahydrofuran; <i>N</i>-methyl-acetamide | 38 EXAMPLE 38 To a solution of 4.17 g (13.8 mmol) of 5-hydroxy-8-(3-pyridyl)-1-(2-tetrahydropyranyloxy)-octane in 30 mL dry dimethylformamide is added 17 mL (27.6 mmol) of a 1.61 M solution of potassium t-butoxide in tetrahydrofuran and the resulting red solution is stirred for 0.5 hour. Then the mixture is cooled to 10° C. and 4.9 g (30.4 mmol) of sodium bromoacetate is added followed by 40 mL dry dimethylformamide, and the reaction mixture stirred at room temperature for 18 hours. The reaction mixture is diluted with ether and water. The ether layer is separated and the aqueous phase is adjusted to pH=6.5 using 1N aqueous hydrochloric acid. The resulting solution is extracted thrice with ethyl acetate. The aqueous phase is again adjusted to pH=6.5 and extracted again. The combined organic phase is washed with brine, dried, filtered, and concentrated to give 8-hydroxy-4-[3-(3-pyridyl)propyl]-3-oxa-octanoic acid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran at 60℃; for 16h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water Electrolysis; | ||
In water |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In not given at 30, 40 and 50°C; | ||
In water in the presence of Na(1+), K(1+), Mg(2+), Ca(2+), Ba(2+) and La(3+) in N2 atm.; | ||
In not given at 25°C with high neutral salt concn. (Na2SO4, MgSO4, NH4NO3, KNO3, Ca(NO3)2, Mg(NO3)2) and NaCl; |
In not given at 25°C, equimolar solns. of 0.25, 0.05 and 0.01m, addition of equimolar amount of neutral salts (NaBr, NaI, NaNO3 and Na2SO4); | ||
In not given from 30 to 90°C; | ||
In water in the presence of Na(1+), K(1+), Mg(2+), Ca(2+), Ba(2+) and La(3+) in N2 atm.; | ||
In not given at 30, 40 and 50°C; | ||
In not given at 25°C with high neutral salt concn. (Na2SO4, MgSO4, NH4NO3, KNO3, Ca(NO3)2, Mg(NO3)2) and NaCl; | ||
In not given at 25°C, equimolar solns. of 0.25, 0.05 and 0.01m, addition of equimolar amount of neutral salts (NaBr, NaI, NaNO3 and Na2SO4); | ||
In not given from 30 to 90°C; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With NaNH2 In ammonia NH3 (liquid); under N2 carborane dissolved in NaNH2/liq. NH3, stirred at -78°Cfor 30 min, organic salt added; warmed to NH3 b.p., residue treated with hexane/H2O, extd. (hexane), aq. phase acidified to pH 1 (concd. HCl), ppt. extd. (Et2O), washed (H2O, satd. NaCl), dried (MgSO4), evapd., dried in vac.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0% | With hydrogenchloride; sodium hydroxide In tetrahydrofuran; ammonia under dry Ar, addn. of THF and Cr(CO)3(C12H14O2) to a suspn. of NaNH2 in liquid NH3, -70°C, stirring, 1 h at -70°C, 30 min at -50°C, addn. of BrCH2COONa; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | With hydrogenchloride; sodium hydroxide In tetrahydrofuran; ammonia under dry Ar, addn. of THF and Cr(CO)3(C12H14O2) to a suspn. of NaNH2 in liquid NH3, -70°C, stirring, 1 h at -70°C, 30 min at -50°C, addn. of BrCH2COONa; evapn. of most of NH3, addn. of NH4Cl, H2O and aq. NaOH, soln. extd. (ether), acidified (HCl) on cooling, extd. (ether), evapn., elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With sodium amide In ammonia addn. of (CH3C6H5)Cr(CO)3 in abs. THF to NaNH2 in liq. NH3 at from -50 to -40°C, stirring for 30 min at this temp., addn. of BrCH2CO2Na to react. mixt.; evapn. of most of NH3 after 30 min, , addn. of H2O and ether to residue, acidifying aq. layer and extg. with ether, crystn. from benzene-heptane, elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With air In water partial oxdn. in the presence of air; pptn. filtered off, washed with ethanol and ethyl ether; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol at 55-60 degree.C for 20 min; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40% | In methanol; water under Ar: dissolving of ((CH3)3NC6H12)VCl3 in a methanol/water mixture; addn. of excess sodium salt of the carboxylic acid; gentle heating to approx. 50°C for 20 min; addn. of KPF6; precipitation;; elem. anal.;; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | In ethanol (protection from light); stirring (4 h); filtration, washing (cold H2O; EtOH; Et2O), drying (vac.); elem. anal.; | |
In not given pptn. on adding AgNO3 to BrCH2COONa soln.; filtration, washing with cold water; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With sodium amide In ammonia addn. of (C6H4(CH2)3)Cr(CO)3 in abs. THF to NaNH2 in liq. NH3 at from -50 to -40°C, stirring for 30 min at this temp., addn. of BrCH2CO2Na to react. mixt.; evapn. of most of NH3 after 30 min, , addn. of H2O and ether to residue, acidifying aq. layer and extg. with ether, crystn. from benzene-heptane, elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With sodium amide In ammonia addn. of (p-CH3C6H4CH3)Cr(CO)3 in abs. THF to NaNH2 in liq. NH3 at from -50 to -40°C, stirring for 30 min at this temp., addn. of BrCH2CO2Na to react. mixt.; evapn. of most of NH3 after 30 min, , addn. of H2O and ether to residue, acidifying aq. layer and extg. with ether, crystn. from benzene-heptane, elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With sodium amide In ammonia addn. of (C6H5CH2CH3)Cr(CO)3 in abs. THF to NaNH2 in liq. NH3 at from -50 to -40°C, stirring for 30 min at this temp., addn. of BrCH2CO2Na to react. mixt.; evapn. of most of NH3 after 30 min, , addn. of H2O and ether to residue, acidifying aq. layer and extg. with ether, crystn. from benzene-heptane, elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With sodium amide In ammonia addn. of (C6H4(CH2)4)Cr(CO)3 in abs. THF to NaNH2 in liq. NH3 at from -50 to -40°C, stirring for 30 min at this temp., addn. of BrCH2CO2Na to react. mixt.; evapn. of most of NH3 after 30 min, , addn. of H2O and ether to residue, acidifying aq. layer and extg. with ether, crystn. from benzene-heptane, elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With hydrogenchloride; sodium amide In tetrahydrofuran; ammonia soln. 3-acylamino-o-carborane in THF was added to stirred mixt. NaNH2 inliquid ammonia at -45°C, stirred for 0.5 h at -50°C, BrCH 2COONa was added and stirred for 1.5 h at -50°C; ammonia was evapd., residue was dissolved in water and acidified with HCl at 0°C, solid was extd. with EtOAc and dried over Na2SO4, solvent was evapd., product was crystd. from EtOAc-heptane; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With hydrogenchloride; sodium amide In tetrahydrofuran; ammonia soln. 3-acylamino-o-carborane in THF was added to stirred mixt. NaNH2 inliquid ammonia at -45°C, stirred for 0.5 h at -50°C, BrCH 2COONa was added and stirred for 1.5 h at -50°C; ammonia was evapd., residue was dissolved in water and acidified with HCl at 0°C, solid was extd. with EtOAc and dried over Na2SO4, solvent was evapd., product was crystd. from EtOAc-heptane; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With hydrogenchloride; sodium amide In tetrahydrofuran; ammonia soln. 3-acylamino-o-carborane in THF was added to stirred mixt. NaNH2 inliquid ammonia at -45°C, stirred for 0.5 h at -50°C, BrCH 2COONa was added and stirred for 1.5 h at -50°C; ammonia was evapd., residue was dissolved in water and acidified with HCl at 0°C, solid was extd. with EtOAc and dried over Na2SO4, solvent was evapd., product was crystd. from EtOAc-heptane; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With hydrogenchloride; sodium amide In tetrahydrofuran; ammonia soln. 3-acylamino-o-carborane in THF was added to stirred mixt. NaNH2 inliquid ammonia at -45°C, stirred for 0.5 h at -50°C, BrCH 2COONa was added and stirred for 1.5 h at -50°C; ammonia was evapd., residue was dissolved in water and acidified with HCl at 0°C, solid was extd. with EtOAc and dried over Na2SO4, solvent was evapd., product was crystd. from EtOAc-heptane; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With hydrogenchloride; sodium amide In tetrahydrofuran; ammonia soln. 3-acylamino-o-carborane in THF was added to stirred mixt. NaNH2 inliquid ammonia at -45°C, stirred for 0.5 h at -50°C, BrCH 2COONa was added and stirred for 1.5 h at -50°C; ammonia was evapd., residue was dissolved in water and acidified with HCl at 0°C, solid was extd. with EtOAc and dried over Na2SO4, solvent was evapd., product was crystd. from EtOAc-heptane; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With hydrogenchloride; sodium amide In tetrahydrofuran; ammonia soln. 3-acylamino-o-carborane in THF was added to stirred mixt. NaNH2 inliquid ammonia at -45°C, stirred for 0.5 h at -50°C, BrCH 2COONa was added and stirred for 1.5 h at -50°C; ammonia was evapd., residue was dissolved in water and acidified with HCl at 0°C, solid was extd. with EtOAc and dried over Na2SO4, solvent was evapd., product was crystd. from EtOAc-heptane; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With hydrogenchloride; sodium amide In tetrahydrofuran; ammonia soln. 3-acylamino-o-carborane in THF was added to stirred mixt. NaNH2 inliquid ammonia at -45°C, stirred for 0.5 h at -50°C, BrCH 2COONa was added and stirred for 1.5 h at -50°C; ammonia was evapd., residue was dissolved in water and acidified with HCl at 0°C, solid was extd. with EtOAc and dried over Na2SO4, solvent was evapd., product was crystd. from EtOAc-heptane; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol Heating / reflux; | 4 2.45 g N, N-dimethyl aminopropyl pentamethyl carbodisilane 1 and 1.61 g sodium 2-bromoacetate were dissolved in 20 ml absolute ethanol. The suspension was heated to reflux overnight until all sodium 2-bromoacetate disappeared. After removing the solvent, the residue was washed with hexane and filtered 4.0 g white solid was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol Reflux; | 10 3-((3-(Di(tert-butyldimethylsiloxy)-methyl-silanyl)-propyl)- dimethyl-amino)-acetate (Figure 10). N, N-dimethyl aminopropyl-di-t-butyl pentamethyl trisiloxane (1.96 g) and sodium 2-bromoacetate (0.81 g) were dissolved in absolute ethanol (20 mL) and charged to a round bottom flask equipped with magnetic stirrer, reflux condenser and N2 inlet. The suspension was heated to reflux overnight until all sodium 2-bromoacetate disappeared. After removal of solvent under reduced pressure, the residue was washed with hexane and filtered. 2.56 g white solid product was obtained. | |
In ethanol Reflux; Inert atmosphere; | 10 3-((3-(Di(tert-butyldimethylsiloxy)-methyl-silanyl)-propyl)- dimethyl-amino)-acetate (Figure 10). N, N-dimethyl aminopropyl-di-t-butyl pentamethyl trisiloxane (1.96 g) and sodium 2-bromoacetate (0.81 g) were dissolved in absolute ethanol (20 mL) and charged to a round bottom flask equipped with magnetic stirrer, reflux condenser and N2 inlet. The suspension was heated to reflux overnight until all sodium 2-bromoacetate disappeared. After removal of solvent under reduced pressure, the residue was washed with hexane and filtered. 2.56 g white solid product was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1.724 g | Stage #1: (+/-)-trans 3,10,13,19-tetraaza-tricyclo[13.3.1.0(4,9)]nonadeca-1(19),15,17-trien-11-one; sodium 2-bromoacetate With sodium hydroxide In methanol; water at 80℃; Stage #2: With hydrogenchloride; water In dichloromethane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | Stage #1: 3-ethenyl-4-(propan-2-yloxy)phenol With sodium hydride In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Stage #2: sodium 2-bromoacetate In tetrahydrofuran Reflux; Inert atmosphere; Stage #3: With hydrogenchloride In water |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: ethylene glycol monoallyl ether With sodium In tetrahydrofuran for 3h; Reflux; Stage #2: sodium 2-bromoacetate In tetrahydrofuran at 20℃; Reflux; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: solfit With sodium hydride In tetrahydrofuran at 40 - 70℃; Inert atmosphere; Stage #2: sodium 2-bromoacetate In tetrahydrofuran at 70℃; for 4.33333h; Inert atmosphere; | 18 A suspension of sodium hydride (4.70 g, 0.19 mol) in anhydrous THF (100 mL) was warmed to approximately 4O°C under an inert atmosphere. A portion of 3- methoxy-3 -methyl- 1-butanol (20.0 g, 0.17 mol) was then added dropwise via syringe over a period of 20 minutes during which time the temperature of the mixture was slowly raised to 7O0C at 5 degree intervals. After one hour, sodium bromoacetate (28.2 g, 0.18 mol) was added in small portions over a period of 20 minutes and the mixture was stirred vigorously at 7O0C for 4 hours. Upon completion (monitored via GC), the mixture was cooled to room temperature, treated with diethyl ether (100 mL) and washed with 10% HCl (aq.) (3 x 75 mL) followed by brine solution (100 mL). The organic phase was dried with MgSCU and the solvent was removed under reduced pressure. The crude light yellow liquid was not purified further for use in subsequent reactions. Yield: (29.2 g, 98.0 %). Odor: harsh, chemical. GC/MS(EI): m/z(%) - 176(1), 161(1), 129(2), 85(30), 73(100), 69(14), 55(9), 45(7). 1H NMR (CDCl3): δ 1.21 (s, 6H), 1.83 (t, J = 5.96 Hz, 2H), 3.21 (s, 3H), 3.66 (t, J = 5.96 Hz, 2H), 3.75 (s, 1H), 4.06 (s, 2H). 13C NMR (CDCl3): δ 25.2, 39.3t 49.4, 68.3, 68.6, 75.0, 173.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | Stage #1: 1,3-bis(selenocyanato)propane With sodium hydroxide In ethanol; water at 20℃; for 2h; Stage #2: With sodium tetrahydroborate In ethanol; water at 20 - 50℃; for 2h; Stage #3: sodium 2-bromoacetate In ethanol; water at 20℃; | |
65% | Stage #1: 1,3-bis(selenocyanato)propane With water; sodium hydroxide In ethanol at 20 - 25℃; for 2h; Stage #2: With sodium tetrahydroborate; water In ethanol at 20 - 50℃; for 2h; Stage #3: sodium 2-bromoacetate | To a solution of NaOH (0.500 g, 12.50 mmol) in 15 ml of a mixture ethanol/water (2/1) was added the above prepared propylene diselenocyanate (0.466 g, 1.85 mmol) and the mixture was stirred for 2 h at room temperature to give an orange solution. NaBH4 (0.500 g, 13.22 mmol) was added and the mixture was stirred for 1 h at room temperature and a further 1 h at 50 °C to give an orange solution and a yellow precipitate. Sodium 2-bromoacetate (0.596 g, 3.71 mmol) was added and the mixture was stirred overnight at room temperature. The white precipitate was removed by filtration and the colorless solution was concentrated under reduced pressure to 5 ml. The pH was adjusted to pH 1 by addition of a 6 M HCI solution. The resulting white precipitate and the remaining aqueous solution were extracted with CH2CI2 and the combined organic layers were washed with water and dried over MgS04. After removal of the solvents under reduced pressure, the residual white solid was washed with cyclohexane and dried under vacuum to give the desired product 4. Yield: 0.380 g (65%); m.p. 75 °C; IR 2860 (m), 2640 (m), 2510 (m), 1678 (s), 1425 (m), 1389 (m), 1271 (s), 1227 (m), 1178 (m), 1159 (m), 1116 (m), 935 (s), 765 (m), 747 (m), 648 (s) cm" 1; JH NMR (DMSO-cfc): δ 2.00 (quint., 2 H, CH2CH2CH2), 2.80 (t, 3 H = 6.8 Hz, 4 H, CH2CH2CH2), 3.20 [s (93%) and d (7%), 2 ¾H = 15.1 Hz, 4 H, SeCH2C02H], 12.50 (br s, 2 H, C02H); 13C NMR (DMSO-4): δ 22.5 [s (93%) and d (7%), /¾ = 67.0 Hz, SeCH2], 24.3 [s (93%) and d (7%), = 61.8 Hz, SeCH2], 29.6 (s, CH2CH2CH2), 172.7 (s, C02H). |
65% | Stage #1: 1,3-bis(selenocyanato)propane With water; sodium hydroxide In ethanol at 20 - 25℃; for 2h; Stage #2: With sodium tetrahydroborate; water In ethanol at 20 - 50℃; for 2h; Stage #3: sodium 2-bromoacetate | To a solution of NaOH (0.500 g, 12.50 mmol) in 15 ml of a mixture ethanol/water (2/1) was added the above prepared propylene diselenocyanate (0.466 g, 1.85 mmol) and the mixture was stirred for 2 h at room temperature to give an orange solution. NaBH4 (0.500 g, 13.22 mmol) was added and the mixture was stirred for 1 h at room temperature and a further 1 h at 50 °C to give an orange solution and a yellow precipitate. Sodium 2-bromoacetate (0.596 g, 3.71 mmol) was added and the mixture was stirred overnight at room temperature. The white precipitate was removed by filtration and the colorless solution was concentrated under reduced pressure to 5 ml. The pH was adjusted to pH 1 by addition of a 6 M HCl solution. The resulting white precipitate and the remaining aqueous solution were extracted with CH2Cl2 and the combined organic layers were washed with water and dried over MgSO4. After removal of the solvents under reduced pressure, the residual white solid was washed with cyclohexane and dried under vacuum to give the desired product 4. Yield: 0.380 g (65%); m.p. 75 °C; IR 2860 (m), 2640 (m), 2510 (m), 1678 (s), 1425 (m), 1389 (m), 1271 (s), 1227 (m), 1178 (m), 1159 (m), 1116 (m), 935 (s), 765 (m), 747 (m), 648 (s) cm-1; 1H NMR (DMSO-d6): δ 2.00 (quint., 2 H, CH2CH2CH2), 2.80 (t, 3JHH = 6.8 Hz, 4 H, CH2CH2CH2), 3.20 [s (93%) and d (7%), 2 J77SeH = 15.1 Hz, 4 H, SeCH2CO2H], 12.50 (br s, 2 H, CO2H); 13C NMR (DMSO-d6): δ 22.5 [s (93%) and d (7%), 2 J77SeH = 67.0 Hz, SeCH2], 24.3 [s (93%) and d (7%), J77SeH = 61.8 Hz, SeCH2], 29.6 (s, CH2CH2CH2), 172.7 (s, CO2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide In water for 1h; Reflux; | 1 Example 1Preparation of a Linking Agent with a Degradable Peptide BondA solution that includes 4,5-dihydroxy-1,3-benzene disulfonic acid disodium salt (TIRON) in water is made basic (to a pH of 10) by the addition of sodium hydroxide (NaOH). A solution of sodium bromoacetate in water is added to the basic TIRON solution and the solution is refluxed for 1 hour. A saturated solution of sodium chloride equal to the reaction volume is added to salt out the intermediate (tetrasodium 2,2'-[(3,5-disulfonato-1,2-phenylene)bis(oxo)]diacetate-FIG. 1A). The salt is placed in water and the pH is adjusted to 2 using hydrochloric acid (HCl). The solution/mixture is dried on a rotary evaporator followed by drying overnight in a vacuum oven at 50° C. at >1 mm Hg.The diacetic acid intermediate is placed in a flask with 2 equivalents of dicyclohexylcarbodiimide (DCC), 2 equivalents of 4-aminobenzophenone, and dry 1,4-dioxane. The mixture is stirred over night and tested for completeness (when the reaction is complete, the solvent is evaporated). The reaction product is dissolved in water and filtered to remove the dicyclohexylurea (DCU). The water is evaporated and the solid is recrystallized from a mixture of ethanol and water. The product (disodium 4,5-bis{2-[(4-benzoylphenyl)amino]-2-oxoethoxy}benzene-1,3-disulfonate-FIG. 1A) is isolated by filtration. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | Stage #1: (1R,4R,5S,6R)-6-(4-methoxybenzyloxy)-4-hydroxy-2,8-dioxa-bicyclo[3.3.0]octane With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Stage #2: sodium 2-bromoacetate In tetrahydrofuran; mineral oil at 80℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47.35% | Stage #1: sodium 2-bromoacetate; fangchinoline With potassium carbonate In butan-1-ol for 4h; Heating; Stage #2: With hydrogen bromide In water; butan-1-ol at 20℃; | 2 Weigh 7-hydroxy-bis-benzyl isoquinoline (Formula in, X = OH) 6.10g, 2- bromo 10.00g sodium acetate andpotassium carbonate 0.50g, Was dissolved in 150mL of n-butanol, was added 500mL three-neck flask, stirredand heated to boiling, and kept the reaction was stirred 4h, evaporated under reduced pressure The solvent wascooled to room temperature, 5% HBr to neutral, add water 50mL and extracted three times with acetone (60mL× 3), TLC chase Separation and isolation of the reaction product of the trace, the extract was dried overanhydrous Na 2 SO 4 dried 8h, Acetone, solids dryness at 60 ° C Dry 4h, as a yellow powder product 3.54g,yield 47.35%, purity 97.23% (HPLC). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50.81% | Stage #1: C37H39BrN2O5; sodium 2-bromoacetate With sodium carbonate In methanol at 20℃; for 48h; Stage #2: With hydrogen bromide In methanol at 20℃; | 4 Weigh 7-bromo-bis-benzyl-isoquinoline (Formula in, X = Br) 6.50g, 2- bromo-sodium acetate 2.20g, 1.20 ,,anhydrous sodium carbonate Was dissolved in 200mL methanol, 500mL three-neck flask, and stirred chilled to -20 ° C, and the reaction was stirred incubated 48h, warmed to room After temperature with 5% HBr to neutral,the solvent was distilled off under reduced pressure to a volume of the liquid reduced to 1/3, crystallization atroom temperature 8h, filtered, TLC The reaction was followed with the product separation and purificationprocess, the resulting solid was dried at 60 ° C 4h, to give the product as a pale yellow powder 3.99g, The yieldwas 50.81%, purity 95.77% (HPLC). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88.03% | With potassium hydroxide In butan-1-ol at 118℃; for 6h; | 2 Weigh 7-hydroxy-bis-benzyl isoquinoline (Formula II in, Χ = 0Η) 6. 22g, 2_ bromine and sodium hydroxide 10. 00g Potassium 0. 60g dissolved in 100mL of n-butanol was added 500mL three-neck flask, stirred and heated to 118 ° C, the reaction was stirred and heated 6h, the solvent was evaporated under reduced pressure, cooled to room temperature, 3% H2S04 to neutral added 50mL of water and extracted with chloroform three times (60mLX 3), the extract was dried over anhydrous Na2S04 dried 8h, recycling chloroform, TLC track separation and purification of the reaction with the product of solids in at 60 ° C drying 2h, to obtain a pale-red powder product 6. 52g, yield 88.03%, purity 97. 36% |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; water; at 20℃; for 12.0h; | Sodium bromoacetic acid, alpha-bromoacetic acid (commercially available, known from the acetic acid to the person skilled in the artOf it can be prepared by methods) and prepared by reacting sodium hydroxidedid. Sodium bromoacetate (483mg, 3.00mmol) is dissolved in water 30mL in 100mL flaskIt was added 25% methanol solution of trimethylamine (3.2M, 1.00mL, 3.2mmol) at room temperature.After completion of the dropwise addition, at room temperature, stirring was continued for 12 hours. After the reaction solution was filtered, the filtrate was concentrated. The resulting ethanol is added to the concentrate, and the resulting crystals were separated by filtration. Further concentrated to dryness filtrateBy to give the trimethyl glycine as a colorless solid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetonitrile; | In this example, the preparation of representative diol zwitterionic monomers isdescribed. The synthesis is shown in Scheme 5. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetonitrile | 5 To a stirred solution of 7 in acetonitrile is added sodium bromoacetate. The reaction mixture is stirred overnight and the product is purified by crystallization. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
4.25 g | With potassium hydroxide In butan-1-ol for 4h; Heating; | 2 660 g of 7-hydroxybisylisoquinoline (formula IIX = OH)2 g of sodium bromoacetate and 0.20 g of potassium hydroxide were dissolved in 150 mL of n-butanol,Was added to a 500 mL three-necked flask,Stirring heated to boiling,And stir-reaction 4h,The solvent was distilled off under reduced pressure,Cooling to room temperature,5% HBr Neutral to Neutral,50 mL of water was added and extracted three times with acetone (60 mL x 3)TLC trace reaction and product separation and purification process,The extract was dried with anhydrous Na2SO4 for 8 h,Recovery of acetone,The solid was dried at 60 ° C for 4 h,To give 4.25 g of product as a yellow powder. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
2.71 g | With potassium carbonate In methanol at -20℃; for 48h; | 4 6.50 g of 7-bromo bis-benzylisoquinoline(formula IIX = Br)sodium 2-bromoacetate 2.20 g, Potassium carbonate 2.20 g,Dissolved in 200mL methanol,Was added to a 500 mL three-necked flask,Stirring frozen to -20 ° C,And stir-stirring reaction 48h,After warming to room temperature with 5% HBr neutralized to neutral,The solvent was distilled off under reduced pressure,200 g of alumina column chromatography,Dichloromethane-methanol (10: 1)TLC trace reaction and product separation and purification process,Collect and merge product flow,The solvent was distilled off at 60 ° C using a rotary evaporator,To give 2.71 g of product as a pale yellow powder. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
233 g (2 M) of sodium monochloroacetate, 500 g of water and 171 g (1 M) of barium hydroxide are charged to a 2000cm3 reactor equipped with a mechanical stirrer, heating, a dropping funnel and a system for rendering inert with nitrogen. The solution is maintained at 0 C. 129 g (1 M) of N-(2-aminoethyl)imidazolidin-2-one in 300 g of water are run in dropwise. After maintaining at ambient temperaturefor 3 hours, 201 g of the barium disalt (barium salt of [2-(2-oxo- 1 -imidazolidinyl)ethylimino]diacetic acid) arerecovered by filtration. The product is resuspended in water and acidified with 98% sulfuric acid. If required, methanol is added to promote the precipitation. 55 g of [2-(2-oxo-1- imidazolidinyl)ethylimino]diacetic acid are thus collected, exhibiting a melting point between 1940 C. and 196 C., measured on a Kofler bench. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With one-round (Pd cube)(at)(Pt nanohelices) core(at)shell In ethanol for 24h; Reflux; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 2-chlorophenothiazine With sodium hydride In tetrahydrofuran for 0.166667h; Stage #2: sodium 2-bromoacetate In tetrahydrofuran for 14h; Reflux; | 1.1-1.3 Experiment 1: (a) 4 mmol of 2-chlorophenothiazine was added to a three-necked flask and dissolved in 20 mL of tetrahydrofuran, and 20 mmol of sodium hydride was added thereto with stirring, and the reaction was stirred for 10 minutes; (b) 4 mmol of sodium bromoacetate was added to the above three-necked flask, and the mixture was heated to reflux. After the reaction for 6 hours, the heating was stopped and the temperature was lowered to room temperature; (c) 40 mmol of sodium hydride was added to the above three-necked flask, and the reaction was stopped after refluxing for 8 hours, and the temperature was lowered to room temperature; (d) Anhydrous ethanol was added to the above three-necked flask to remove excess sodium hydride, and the mixture was suction filtered under reduced pressure. The obtained filtrate was evaporated to dryness on a rotary evaporator to obtain a solid. The obtained solid was acidified in ethanol and then separated by column chromatography to obtain a compound represented by formula 1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene at 90℃; for 10h; | 2.5 Add 0.1 mol of sodium bromoacetate to 0.05 mol of bicyclic imidazoline, dissolve in 100 ml of toluene, and react at 90 ° C for 10 hours. After the reaction is completed, remove the solvent to obtain cationic bicyclic imidazoline |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium hydroxide monohydrate; water at 0 - 30℃; for 24h; | Embodiment 38 Cyclen (17.27 g, 100 mmol), lithium hydroxide monohydrate (18.46 g, 440 mmol) and water (80 mL) were added into a three-necked flask (1000 mL) at 0-10° C. A solution of sodium bromoacetate (51.25 g, 440 mmol) in water (30 mL) was added at 5-15° C. The mixture was warmed to 20-30° C. and reacted for 24 hours. No surplus of the raw material cyclen was detected by TLC. 36% hydrochloric acid (44.6 g, 880 mmol) and ethanol (600 mL) were added to the system for solids precipitation, followed by filtration. The resulting solids were purified by recrystallization with ethanol/water (volume ratio 3:1) and dried at 60° C. to obtain DOTA. Yield: 67.8%, HPLC: 75.5%, residue on ignition: 1.23%, moisture: 7.23%. Wherein, the HPLC spectrum of the product was shown in FIG. 2, and the purity data was shown in Table 2; the retention time of which was 9.580 minute. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: [3aS-(3aα,4α,6α,6aα)]-(tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)carbamic acid phenylmethyl ester; sodium 2-bromoacetate With potassium <i>tert</i>-butylate In tetrahydrofuran at 0 - 10℃; for 2.25h; Stage #2: chloroformic acid ethyl ester In tetrahydrofuran at 10 - 20℃; for 1h; | 1; 3 Example 1: Preparation of compound III Put 100g of compound I and 800mL of tetrahydrofuran into a 2L four-necked flask 1, and cool to 0-10°C. Slowly add 40.1g of potassium tert-butoxide into flask 1.After the addition, continue to stir for 15 minutes, and then slowly add 62.5g of sodium bromoacetate in batches to bottle 1 at 0-10°C.After the addition, the stirring was continued for 2 hours, and then the temperature was raised to 10-20°C and 45.7 g of ethyl chloroformate was slowly added dropwise to the flask 1.The temperature is controlled at 10-20°C and the reaction is stirred for 1h, and then the temperature is lowered to 0-10°C and 29.7g sodium borohydride is slowly added in batches.After incubating at 0-10°C and reacting for 4 hours, 30% acetic acid aqueous solution was added dropwise to quench the reaction, the pH was adjusted to 4-5, and the tetrahydrofuran was removed by concentration under reduced pressure.Then 500 mL of water was added and extracted with ethyl acetate (200 mL×3), the organic phases were combined and washed once with 200 mL of saturated brine, and dried over anhydrous sodium sulfate to obtain 93.1 g of light yellow oily compound III with a yield of 81.39%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
35% | Stage #1: carbon disulfide; 3-amino propanoic acid With sodium hydroxide In water at 20℃; for 24h; Stage #2: sodium 2-bromoacetate In water at 20℃; for 24h; Stage #3: With hydrogenchloride for 24h; Reflux; | To a solution of β-alanine (1 g, 12.49 mmol) and NaOH (0.5 g, 12.49 mmol) in H2O(35 mL) CS2 (2.25 mL, 37.46 mmol) was added dropwise, in such a manner that the temperatureof the reaction did not exceed 25 °C and the mixture was stirred at room temperaturefor 24 h. A solution of sodium bromoacetate, obtained by solubilizing bromoacetic acid(1.73 g, 12.49 mmol) and NaOH (0.5 g, 12.49 mmol) in H2O (45 mL), was added and themixture was stirred at room temperature for a further 24 h. The mixture was acidifiedwith HCl 6M until pH 3-4 and refluxed for 24 h. The mixture was then cooled and pouredinto H2O, providing a pale yellow precipitate. Then, if necessary, pH was adjusted againto 3-4 by the addition of HCl 6M and the solid was filtered off. The aqueous solutionwas extracted with ethyl acetate; the organic phase was washed with H2O, dried withanhydrous Na2SO4 and evaporated under reduced pressure, providing a further amount of3-(4-oxo-2-thioxothiazolidin-3-yl)propanoic acid (7). The solid residue and the precipitatewere collected and washed with ethyl ether to give pure compound 7. Yield 35% (897.2 mg);mp 159-162 °C; 1H-NMR (CDCl3): δ 2.77 (t J = 6 Hz, 2H, CH2COOH), 4.01 (s, 2H, 5-CH2)4.31 (t J = 6 Hz, 2H, NCH2). Anal. (C6H7NO3S2) calcd: C 35.11; H 3.44; N 6.82; found: C34.96, H 3.34, N 6.92. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: sodium 2-bromoacetate; 2-amino-2-hydroxymethyl-1,3-propanediol In methanol; water at 60℃; for 4h; Stage #2: at 65℃; for 6h; Acidic conditions; | 5 Example 5 Preparation method of tris (hydroxymethyl) methylglycine, comprising the following preparation steps: Preparation step S1: Under stirring conditions, a mixture of compound I trimethylolomethane, compound A, reaction solvent methanol and water was added to the drying reactor of 1L, the molar ratio of compound I and compound A was 1:2, the reaction oil bath temperature was 60 °C, the reaction pressure was 0MPa (gauge pressure), and the reaction time was 4h. After the completion of the reaction, it is reduced to room temperature, the insoluble substances are filtered out, the filtrate is rotated under reduced pressure and evaporated to remove the solvent, concentrated, and the crude product of Compound II is prepared; Wherein, Compound A is sodium bromoacetate. Preparation step S2: Under stirring conditions, 20g of compound II was added to the 1L drying reactor, and after acid-base treatment, the sodium salt became the corresponding acid, the reaction oil bath temperature was 65 °C, the reaction pressure was 0MPa (gauge pressure), and the reaction time was 6h. After the reaction is completed, it is reduced to room temperature, the insoluble matter is filtered out, the filtrate is evaporated under reduced pressure and rotated to remove the solvent, concentrated, and the crude product of tris (hydroxymethyl) methylglycine is prepared, with a crude product yield of 93%. Preparation step S3: Under dry conditions, using drying closed equipment, the crude tris (hydroxymethyl) methylglycine obtained in step S2 was dissolved in a mixture of purified solvent methanol and water, and then recrystallized, and then crystallized, filtered and dried at low temperatures to obtain a refined tri(hydroxymethyl) methylglycine product with a fine purity of 99.6%. |
Tags: 1068-52-6 synthesis path| 1068-52-6 SDS| 1068-52-6 COA| 1068-52-6 purity| 1068-52-6 application| 1068-52-6 NMR| 1068-52-6 COA| 1068-52-6 structure
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P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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