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[ CAS No. 106877-20-7 ] {[proInfo.proName]}

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Product Details of [ 106877-20-7 ]

CAS No. :106877-20-7 MDL No. :MFCD11840978
Formula : C8H8F3NO Boiling Point : -
Linear Structure Formula :- InChI Key :QRLOMWASJXMURT-UHFFFAOYSA-N
M.W : 191.15 Pubchem ID :13750441
Synonyms :

Safety of [ 106877-20-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 106877-20-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 106877-20-7 ]
  • Downstream synthetic route of [ 106877-20-7 ]

[ 106877-20-7 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 453560-74-2 ]
  • [ 106877-20-7 ]
YieldReaction ConditionsOperation in experiment
7 g With 5%-palladium/activated carbon; hydrogen In methanol at 20℃; for 45 h; Intermediate 444 (7. 1 g, 28.9 mmol ) was taken up into methanol ( 100 niL and then 5percent Pd/C (0.7 g. ) was added. The mixture was hydrogenated at room temperature for 48 hours under (50 Psi) atmosphere. The mixture was filtered and the filtrate was evaporated under vacuum to obtain intermediate 445 ( 7 g ) as a white solid.
Reference: [1] Journal of Medicinal Chemistry, 2014, vol. 57, # 5, p. 1914 - 1931
[2] Patent: US2010/311760, 2010, A1, . Location in patent: Page/Page column 42-43
[3] Patent: WO2017/32840, 2017, A1, . Location in patent: Page/Page column 226
  • 2
  • [ 887144-94-7 ]
  • [ 536-90-3 ]
  • [ 654-83-1 ]
  • [ 106877-20-7 ]
  • [ 53982-03-9 ]
YieldReaction ConditionsOperation in experiment
23% With potassium carbonate; nickel(II) hydroxide In dimethyl sulfoxide at 35℃; for 2 h; In the preparation method of the trifluoromethyl aromatic amine of the present embodiment, the aromatic amine is m-methoxyaniline, and other reaction and post- treatment processes are the same as in Example 28, and three kinds of trifluoromethyl aromatic amine products are obtained.
The preparation method of the trifluoromethyl aromatic amine of the present embodiment, the aromatic amine is aniline, and the nickel compound is nickel hydroxide.The base is potassium carbonate, and the reaction process parameters are: 1-trifluoromethyl-1,2-phenyliodo-3(H)-one (0.5 mmol, 1.0 eq).Aromatic amine (1.5 mmol, 3.0 eq), nickel hydroxide 10 molpercent, potassium carbonate (1.5 mmol, 3.0 eq),DMSO (2 mL) was reacted at 35 ° C for 2 h, and the other reactions and workup procedures were the same as in Example 1.
Reference: [1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A, . Location in patent: Paragraph 0090-0094; 0098-0100; 0104-0106
  • 3
  • [ 75-63-8 ]
  • [ 536-90-3 ]
  • [ 654-83-1 ]
  • [ 106877-20-7 ]
  • [ 53982-03-9 ]
  • [ 106877-19-4 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990, # 8, p. 2293 - 2299
[2] Journal of the Chemical Society, Chemical Communications, 1987, p. 1701 - 1703
  • 4
  • [ 5458-84-4 ]
  • [ 106877-20-7 ]
Reference: [1] Journal of Medicinal Chemistry, 2014, vol. 57, # 5, p. 1914 - 1931
[2] Patent: WO2017/32840, 2017, A1,
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