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[ CAS No. 1073160-19-6 ] {[proInfo.proName]}

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Chemical Structure| 1073160-19-6
Chemical Structure| 1073160-19-6
Structure of 1073160-19-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1073160-19-6 ]

CAS No. :1073160-19-6 MDL No. :MFCD28972477
Formula : C13H10ClF3N4O Boiling Point : -
Linear Structure Formula :- InChI Key :IJEBTSOYCUVHFB-UHFFFAOYSA-N
M.W : 330.69 Pubchem ID :57584546
Synonyms :

Safety of [ 1073160-19-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1073160-19-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1073160-19-6 ]
  • Downstream synthetic route of [ 1073160-19-6 ]

[ 1073160-19-6 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1073160-19-6 ]
  • [ 1073154-85-4 ]
YieldReaction ConditionsOperation in experiment
78% With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane; <i>tert</i>-butyl alcohol at 80℃; for 9 h; Example 15; Preparation of 4-(4-[(3-methanesulfonyl-methyl-amino)-pyrazin-2-ylmethyl]-amino}-5-(trifluoromethyl)-pyrimidin-2-ylamino)-N-methyl-benzamide (15) Step 1. A suspension of B20 (0.3 mmol), B2 (0.3 mmol), and diisopropylethyl amine (0.9 mmol) in 1:1 (v:v) DCE/tBuOH was mixed at 80° C. for 9 hours. The mixture was allowed to cool to 25° C., and it was mixed at 25° C. for 20 hours. The mixture was then treated with 9:1 (v:v) ether/ethanol. The solids were collected and washed with water to provide 15. Yield: 0.23 mmol, 78percent. HPLC (KDC 10-90) 3.526 min. 1H NMR (500 MHz, d6-DMSO) δ ppm 9.83 (s, 1H), 8.69 (d, J=2.59 Hz, 1H), 8.58 (d, J=2.59 Hz, 1H), 8.31 (s, 1H), 8.20 (d, J=4.67 Hz, 1H), 7.58-7.70 (m, 3H), 7.41 (t, J=5.18 Hz, 1H), 5.00 (d, J=5.18 Hz, 2H), 3.23 (s, 3H), 3.20 (s, 3H), 2.75 (d, J=4.15 Hz, 3H). FAK IC50: <0.000595 μM (Table 1, Example 317)
Reference: [1] Patent: US2009/54395, 2009, A1, . Location in patent: Page/Page column 53
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