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Chemical Structure| 1075260-64-8 Chemical Structure| 1075260-64-8

Structure of 1075260-64-8

Chemical Structure| 1075260-64-8

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Product Details of [ 1075260-64-8 ]

CAS No. :1075260-64-8
Formula : C8H7N3
M.W : 145.16
SMILES Code : C=CC1=CN2C(C=C1)=NC=N2
MDL No. :MFCD30729764

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Application In Synthesis of [ 1075260-64-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1075260-64-8 ]

[ 1075260-64-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 356560-80-0 ]
  • 2,4,6-trivinylcyclotriboroxane*pyridine complex [ No CAS ]
  • [ 1075260-64-8 ]
YieldReaction ConditionsOperation in experiment
93% (b) 6-Ethenyl[l,2,4]triazolo[l,5-.]pyridine; 6-Bromo[l,2,4]triazolo[l,5-alpha]pyridine (0.5g, 2.5mmol) was dissolved in degassed DME (2OmL) under argon and tetrakis triphenylphosphine palladium (58mg, 0.05mmol) was added under argon and the orange solution was stirred at room temperature under argon for about 40 minutes. Potassium carbonate (345mg, 2.5mmol), water (4mL) and triethenylboroxin pyridine complex (for a synthesis see Kerins, F.; O'Shea, D. J. Org. Chem. (2002), 67(14), 4968-4971) (162mg, lmmol) were then added and the mixture was stirred at reflux for 4h (the colour of the reaction changed to yellow). The reaction was stirred at reflux overnight. A further 1% of tetrakis triphenylphosphine palladium, 0.2eq of triethenylboroxin pyridine complex and lOOmg of potassium carbonate were added and the reaction was stirred at reflux for Ih. The reaction was cooled to room temperature, diethylether was added and the aqueous was extracted (3x80mL).The organics were dried (magnesium sulphate), filtered and reduced to afford a solid which was subjected to silica chromatography (0-5% methanol in dichloromethane) to afford the title compound (340mg, 93%). MS (ES+) m/z 146 (MH+).
 

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