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[ CAS No. 107960-02-1 ] {[proInfo.proName]}

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Chemical Structure| 107960-02-1
Chemical Structure| 107960-02-1
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Product Details of [ 107960-02-1 ]

CAS No. :107960-02-1 MDL No. :
Formula : C7H5Cl4NO5 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :324.93 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 107960-02-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 107960-02-1 ]
  • Downstream synthetic route of [ 107960-02-1 ]

[ 107960-02-1 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 15761-38-3 ]
  • [ 107960-02-1 ]
  • [ 3392-05-0 ]
YieldReaction ConditionsOperation in experiment
94% With 4-methyl-morpholine In tetrahydrofuran; ethyl acetate; Petroleum ether EXAMPLE 11:
PREPARATION OF N-SUCCINIMIDYL N-TERT-BUTYLOXYCARBONYL-L-ALANINATE
0.95 g (5 mmol) of N-tert-butyloxycarbonyl-L-alanine and 0.66 ml (5.5 mmol) of N-methylmorpholine are dissolved in 6 ml of THF, and 1.8 g (5.5 mmol) of N-succinimidyl 1,2,2,2-tetrachloroethyl carbonate is added in a single portion.
The mixture is stirred for two hours at 20° C.
Approximately 25 ml of ethyl acetate are added and the organic phase is washed rapidly with N HCl solution, then with potassium bicarbonate solution and finally twice with water.
The organic phase is dried over magnesium sulphate and evaporated.
The residue is crystallized in an ethyl acetate/petroleum ether mixture and 1.25 g (Y=87percent) of white crystals are obtained.
Evaporation of the mother liquors and crystallisation enables a further 0.1 g to be recovered, and this brings the yield to 94percent.
M.p. (melting point)=158° C. [α]D20 =50.7 (c=2, dioxane)
Reference: [1] Journal of Organic Chemistry, 1987, vol. 52, # 12, p. 2364 - 2367
[2] Patent: US4782164, 1988, A,
  • 2
  • [ 13734-34-4 ]
  • [ 107960-02-1 ]
  • [ 3674-06-4 ]
Reference: [1] Journal of Organic Chemistry, 1987, vol. 52, # 12, p. 2364 - 2367
  • 3
  • [ 4530-20-5 ]
  • [ 107960-02-1 ]
  • [ 3392-07-2 ]
Reference: [1] Journal of Organic Chemistry, 1987, vol. 52, # 12, p. 2364 - 2367
  • 4
  • [ 13734-41-3 ]
  • [ 107960-02-1 ]
  • [ 3392-12-9 ]
Reference: [1] Journal of Organic Chemistry, 1987, vol. 52, # 12, p. 2364 - 2367
  • 5
  • [ 1138-80-3 ]
  • [ 107960-02-1 ]
  • [ 2899-60-7 ]
Reference: [1] Journal of Organic Chemistry, 1987, vol. 52, # 12, p. 2364 - 2367
  • 6
  • [ 2389-45-9 ]
  • [ 107960-02-1 ]
  • [ 34404-36-9 ]
Reference: [1] Journal of Organic Chemistry, 1987, vol. 52, # 12, p. 2364 - 2367
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