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Chemical Structure| 1082066-49-6 Chemical Structure| 1082066-49-6

Structure of 1082066-49-6

Chemical Structure| 1082066-49-6

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Product Details of [ 1082066-49-6 ]

CAS No. :1082066-49-6
Formula : C8H8N4O
M.W : 176.18
SMILES Code : O=CC1=CN(C2=CN(C)C=N2)N=C1
MDL No. :MFCD24686506

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Application In Synthesis of [ 1082066-49-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1082066-49-6 ]

[ 1082066-49-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25676-75-9 ]
  • [ 35344-95-7 ]
  • [ 1082066-49-6 ]
YieldReaction ConditionsOperation in experiment
20% With dimethylaminoacetic acid; potassium carbonate;copper(l) iodide; In dimethyl sulfoxide; at 110℃; for 66h; Preparation 62: 1 -(I -Methyl- lH-imidazol-4-y I)- 1 H-<strong>[35344-95-7]pyrazole-4-carbaldehyde</strong>In an oven-dried flask, combine 4-bromo-l -methyl- lH-imidazole (0.200 g, 1.24mmol), copper (I) iodide (0.022g, 0.113 mmol), N,N-dimethylglycine (0.023 g, 0.226 mmol), and potassium carbonate (0.312 g, 2.26 mmol). Purge with nitrogen 3 times.Add l-H-<strong>[35344-95-7]pyrazole-4-carboxaldehyde</strong> (0.109 g, 1.13 mmol), and DMSO (1.7 mL). Heat to 110 0C for 48 hr. Cool to ambient temperature and partition between ethyl acetate and water. Separate organic layer and extract aqueous layer twice with ethyl acetate. Dry <n="64"/>--63-combined organic layers (magnesium sulfate), filter and concentrate. Add copper (I) iodide (0.022 g, 0.113 mmol), N,N-dimethylglycine (0.023 g, 0.226 mmol), potassium carbonate (0.312 g, 2.26 mmol), and DMSO (1.7 mL). Purge with nitrogen 3 times. Heat to 110 0C for 18 hr. Cool to ambient temperature and partition between ethyl acetate and water. Separate organic layer and extract aqueous layer twice with ethyl acetate. Dry combined organic layers (magnesium sulfate), filter, concentrate, and purify (silica gel chromatography, eluting with 50:50 to 100:0 ethyl acetate: hexanes) to give the title preparation (39 mg, 20percent). GC-MS: m/z = 176 [M+].
 

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