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Chemical Structure| 1086599-47-4 Chemical Structure| 1086599-47-4

Structure of 1086599-47-4

Chemical Structure| 1086599-47-4

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Product Details of [ 1086599-47-4 ]

CAS No. :1086599-47-4
Formula : C10H9BrFN
M.W : 242.09
SMILES Code : CC(C)(C1=CC=C(F)C=C1Br)C#N

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Application In Synthesis of [ 1086599-47-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1086599-47-4 ]

[ 1086599-47-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 61150-58-1 ]
  • [ 74-88-4 ]
  • [ 1086599-47-4 ]
YieldReaction ConditionsOperation in experiment
65% Add sodium hydride (1 g, 42.1 mmol) to a stirred solution of (2-bromo-4- fluoro-phenyl)-acetonitrile (3 g, 14 mmol) in 10 mL of dimethyl formamide (DMF) at 0 0C. Stir the mixture at 0 0C to RT for half an hour. Add methyl iodide (6 g, 42 mmol). Stir for another 30 min. Quench the reaction with water. Extract the product into DCM. Dry the organic phase over sodium sulfate and concentrate to give an oily residue. Purify the residue by flash column chromatography (FCC) (hexane to 20 % ethyl acetate in hexane as gradient elute) to give the title compound as a white solid (2.2 g, 65 %). 1H NMR (400 MHz, CDCl3) delta 7.41-7.47 (m, 2H), 7.03-7.08 (m, IH), 1.88 (s, 6H).
 

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