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[ CAS No. 1092563-25-1 ] {[proInfo.proName]}

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Chemical Structure| 1092563-25-1
Chemical Structure| 1092563-25-1
Structure of 1092563-25-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1092563-25-1 ]

CAS No. :1092563-25-1 MDL No. :MFCD22056473
Formula : C17H26BNO4S Boiling Point : -
Linear Structure Formula :- InChI Key :PZWLWAYUUJLSJL-UHFFFAOYSA-N
M.W : 351.27 Pubchem ID :59392782
Synonyms :

Safety of [ 1092563-25-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1092563-25-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1092563-25-1 ]
  • Downstream synthetic route of [ 1092563-25-1 ]

[ 1092563-25-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1092563-25-1 ]
  • [ 1142943-96-1 ]
  • [ 1206161-97-8 ]
YieldReaction ConditionsOperation in experiment
11 g With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 90℃; for 12 h; 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzyl)thiomorpholine 1,1-dioxo(Intermediate 1A) (20.18 g, 53 mmol),N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide (Intermediate 7A) (16.45 g, 59 mmol),Pd(dppf)Cl2 (3.91 g, 5 mmol),2CO3 (22.06 g, 160 mmol) was added in turn to a 250 mL three-vial flask.Then add 1,4-dioxane (100 mL),Water (25mL),The temperature was raised to 90° C. under argon protection for 12 hours.After the reaction is over,Cool to room temperatureAdd 300 mL of dichloromethane to the reaction mixture.Then wash twice with water,500mL each time,Drying the organic phase with anhydrous sodium sulfate,The organic phase is concentrated to dryness,The residue is subjected to column chromatography (eluent:Dichloromethane:methanol = 50:1) was purified to give the title product as a pale yellow solid, 11 g.
Reference: [1] Journal of Medicinal Chemistry, 2014, vol. 57, # 22, p. 9323 - 9342
[2] Drugs of the Future, 2014, vol. 39, # 8, p. 547 - 551
[3] Patent: US2015/224199, 2015, A1, . Location in patent: Paragraph 0280-0283
[4] Patent: US2015/225398, 2015, A1, . Location in patent: Paragraph 0270; 0271; 0272; 0273
[5] Patent: WO2016/165952, 2016, A1, . Location in patent: Paragraph 0168-0169
[6] Patent: CN107759587, 2018, A, . Location in patent: Paragraph 0268-0269
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