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Chemical Structure| 1092961-38-0 Chemical Structure| 1092961-38-0

Structure of 1092961-38-0

Chemical Structure| 1092961-38-0

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Product Details of [ 1092961-38-0 ]

CAS No. :1092961-38-0
Formula : C6H6F2N2O2
M.W : 176.12
SMILES Code : O=C(C1=CNN=C1C(F)F)OC
MDL No. :MFCD16619898

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Application In Synthesis of [ 1092961-38-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1092961-38-0 ]

[ 1092961-38-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1550-50-1 ]
  • [ 34846-90-7 ]
  • [ 1092961-38-0 ]
YieldReaction ConditionsOperation in experiment
53%Chromat. To a solution of 1,1,2,2-tetrafluoroethyldimethylamine (96percent, 46 g, 305 mmol) in acetonitrile (100 ml) was added dropwise, at 25° C. under argon, BF3-etherate (36.8 g, 259 mmol). Subsequently, under reflux conditions (approx. 70° C.), a solution of methyl 3-methoxyacrylate (95percent, 31.6 g, 259 mmol) in acetonitrile (75 ml) was added dropwise to the reaction mixture within 1 h. After stirring under reflux conditions for a further 26 h, the reaction mixture was cooled to 25° C. The resulting reaction mixture was added dropwise at 0 to 15° C. to a solution of hydrazine hydrate (66.5 g, 850 mmol) in acetonitrile (100 ml) within 1 h. After stirring at 25° C. for a further hour, a sample of the solution was taken and analyzed by HPLC analysis. According to HPLC analysis, the reaction mixture comprised, as the main product (53 area percent) methyl 3-difluoromethyl-1H-pyrazole-4-carboxylate (retention time: 10 min; HPLC-MS: (m/z)=177).
 

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