Alternatived Products of [ 1093066-77-3 ]
Product Details of [ 1093066-77-3 ]
| CAS No. : | 1093066-77-3 |
MDL No. : | |
| Formula : |
C13H24N2O2
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Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
240.34
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Pubchem ID : | - |
| Synonyms : |
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Safety of [ 1093066-77-3 ]
Application In Synthesis of [ 1093066-77-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1093066-77-3 ]
- 1
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[ 50-00-0 ]
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[ 929302-18-1 ]
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[ 1093066-77-3 ]
| Yield | Reaction Conditions | Operation in experiment |
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To a solution of <strong>[929302-18-1]2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester hydrochloride</strong> (100 mg, 0.381 mmol) in DCE (10 mL) was added an aqueous solution of formaldehyde (37 percent w/w, 40 muL, 0.537 mmol). The mixture was stirred at RT for 10 min, then sodium triacetoxyborohydride (121 mg, 0.571 mmol) was added and stirring was continued for 1 h. Water was added to the reaction mixture before being loaded onto an Isolute.(R). SCX-2 cartridge. The cartridge was washed with MeOH then eluted with 2 M NH3 in MeOH to give 7-methyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester. To a solution of 7-methyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester in DCM (5 mL) was added TFA (1 mL) and the resulting mixture was stirred at RT for 1 h. The reaction mixture was loaded onto an Isolute.(R). SCX-2 cartridge, washed with MeOH then eluted with 2 M NH3 in MeOH to give the title compound as a colourless oil (45 mg, 84 percent). 1H NMR (400 MHz, CDCl3): delta 1.81 (m, 4 H), 2.22 (s, 3 H), 2.28 (m, 2 H), 3.22 (bs, 4 H) and 3.38 (bs, 2 H). |
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To a solution of <strong>[929302-18-1]2,7-diazaspiro[3.5]nonane-2-carboxylic acid tert-butyl ester hydrochloride</strong> (100 mg, 0.381 mmol) in DCE (10 mL) was added an aqueous solution of formaldehyde (37 percent w/w, 40 muL, 0.537 mmol). The mixture was stirred at RT for 10 min, then sodium triacetoxyborohydride (121 mg, 0.571 mmol) was added and stirring was continued for 1 h. The reaction mixture was added water and loaded onto an Isolute.(R). SCX-2 cartridge, washed with MeOH then eluted with 2 M NH3 in MeOH to give 7-methyl-2,7- diazaspiro[3.5]nonane-2-carboxylic acid tert-butyl ester. To a solution of 7-methyl-2,7- <n="49"/>^diazaspiro[3.5]nonane-2-carboxylic acid fert-butyl ester in DCM (5 mL) was added TFA (1 mL) and the resulting mixture was stirred at RT for 1 h. The reaction mixture was loaded onto an Isolute.(R). SCX-2 cartridge, washed with MeOH then eluted with 2 M NH3 in MeOH to give the title compound as a colourless oil (45 mg, 84 percent). 1H NMR (400 MHz, CDCl3): delta 1.81 (m, 4 H), 2.22 (s, 3 H), 2.28 (m, 2 H), 3.22 (bs, 4 H) and 3.38 (bs, 2 H). |
- 2
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[ 929301-99-5 ]
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[ 1093066-77-3 ]
Categories
Chemistry
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Material Science
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110K+ Compounds
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