Home Cart Sign in  
Chemical Structure| 1093881-08-3 Chemical Structure| 1093881-08-3

Structure of 1093881-08-3

Chemical Structure| 1093881-08-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1093881-08-3 ]

CAS No. :1093881-08-3
Formula : C7H9ClN2O
M.W : 172.61
SMILES Code : CC(O)(C1=NN=C(Cl)C=C1)C
MDL No. :MFCD16988471

Safety of [ 1093881-08-3 ]

Application In Synthesis of [ 1093881-08-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1093881-08-3 ]

[ 1093881-08-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 676-58-4 ]
  • [ 65202-50-8 ]
  • [ 1093881-08-3 ]
YieldReaction ConditionsOperation in experiment
A solution of THF (2.5 mL) and toluene (10 mL), and methylmagnesiurn chloride (3.0 M, 9.7 mL) were stirred at -2O0C under N2 atmosphere followed by the addition of f-BuOH (0.5 mL, 5.79 mrnol) in THF (7 mL) dropwise. The solution was allowed to stir for 30 min and warmed to 30C and cooled backed down to -200C followed by the addition of the methyl 6- chloropyridazine-3-carboxylate (1.0 g, 5.79 mmol) in portions. The solution quickly turned dark violet and was stirred at 00C for 30 min. The solution was then poured into a flask containing 1 N aqueous hydrochloric acid at -50C, diluted with ethyl acetate, and stirred for 10 min. The layers were then separated and the organic layer was washed with saturated aqueous sodium bicarbonate and brine. The acidic aqueous layer was neutralized with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic layers were combined and concentrated in vacuo. Purification via flash chromatography (silica, 0-100percent ethyl acetate/hexanes) provided the title compound. LRMS (ESI) calc'd for C7H10ClN2O [M+H]+: 173.1, Found: 173.1
 

Historical Records