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Chemical Structure| 109480-78-6 Chemical Structure| 109480-78-6

Structure of 109480-78-6

Chemical Structure| 109480-78-6

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Product Details of [ 109480-78-6 ]

CAS No. :109480-78-6
Formula : C6H13NO2
M.W : 131.17
SMILES Code : CCCC(N(OC)C)=O
MDL No. :MFCD14707556
InChI Key :KHNDGDMDYRDYBR-UHFFFAOYSA-N
Pubchem ID :13704543

Safety of [ 109480-78-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 109480-78-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 109480-78-6 ]

[ 109480-78-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19063-55-9 ]
  • [ 109480-78-6 ]
  • C13H12O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With magnesium; In tetrahydrofuran;Inert atmosphere; (1) Under a N2 protection, add magnesium chips (20 mmol) to a 100 mL round bottom flask, and add 2 mL of dry tetrahydrofuran (THF) and stir. Dissolve 4-bromocoumarin (2 mmol) in 5 mL of THF. The needle was injected, heated with a hair dryer, and the mixed solution was kept in a micro-boiling state for 2 min, and then the remaining 4-bromocoumarin (18 mmol) and Weinreb amide (10 mmol) were dissolved in 10 mL of THF solution and slowly added dropwise to the reaction system. After maintaining the micro-boiling state, add 10 mL of THF after the addition, and continue to stir the reaction at room temperature. After the reaction was completely monitored by TLC, 10 mL of a saturated ammonium chloride solution was added to the reaction mixture, stirred for 10 min, and then extracted three times with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, and the solvent was evaporated. White solid, yield: 81%.
 

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