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Chemical Structure| 109573-05-9 Chemical Structure| 109573-05-9

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Chemical Structure| 109573-05-9

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Product Details of [ 109573-05-9 ]

CAS No. :109573-05-9
Formula : C12H18N2O2
M.W : 222.28
SMILES Code : O=C(OC(C)(C)C)NCCC1=CC=NC=C1
MDL No. :MFCD01318366

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 109573-05-9 ]

[ 109573-05-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42881-66-3 ]
  • [ 109573-05-9 ]
  • [ 774609-76-6 ]
YieldReaction ConditionsOperation in experiment
74% With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 - 100℃; for 18h; To a solution of (2-piperidin-4-ylethyl) carbamic acid tert-butyl ester (2.1 g, 9.2 mmole) in DMF (5 mL) at RT was added <strong>[42881-66-3]4-bromo-6-methoxyquinoline</strong> (2.0 g, 8.4 mmole) and Et3N (0.86 g, 8.37 mmole). After 18 hour at 100 C, the reaction solution was concentrated under vacuum and purified by flash chromatography on silica gel (CHCTG/MEOH containing 5% NH40H, 9: 1) to afford the title compound as a tan solid (2.39 g, 74%) : 1 H NMR (400 MHz, CDCl3) 8.61 (m, 1 H), 8.03 (m, 1 H), 7.37 (m, 1 H), 7.22 (m, 1 H), 6.85 (m, 1 H), 4.57 (br s, 1 H), 3.98 (s, 3H), 3.72 (m, 1 H), 3.25 (m, 1 H), 2.99 (app s, 2H), 2.90 (app s, 2H), 2.80 (m, 2H), 1.95 (m, 1 H), 1.65-1. 50 (m, 4H), 1.48 (s, 9H). LC- MS (ES) m/e 386 (M + H) +.
 

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