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Chemical Structure| 1105510-16-4 Chemical Structure| 1105510-16-4

Structure of 1105510-16-4

Chemical Structure| 1105510-16-4

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Product Details of [ 1105510-16-4 ]

CAS No. :1105510-16-4
Formula : C10H13F2NO2
M.W : 217.21
SMILES Code : FC1=CC=C(C(OCC)OCC)C(F)=N1

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Application In Synthesis of [ 1105510-16-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1105510-16-4 ]

[ 1105510-16-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 122-51-0 ]
  • [ 155601-65-3 ]
  • [ 1105510-16-4 ]
YieldReaction ConditionsOperation in experiment
toluene-4-sulfonic acid; In ethanol;Heating / reflux; A solution of <strong>[155601-65-3]2,6-difluoronicotinaldehyde</strong> (5 g, 34.94 mmol), triethyl orthoformate (8.72 ml, 52.41 mmol) and p-toluenesulfonic acid (0.562 mL, 3.49 mmol) in ethanol (50 mL) was heated at reflux overnight. Solvent was removed and the residue was diluted with EtOAc and washed with aqueous K2CO3 and brine. Drying (MgSO4) and removal of solvent gave an oil. The oil was distilled under high vacuum conditions bulb-to-bulb to give 2.85 g of product as a clear, colorless oil.1H NMR: 1.25 (t, 3H), 3.5-3.7 (m 2H), 5.6 (s, IH), 6.85 (d, 2H), 8.1 (dd, IH).
 

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