Alternatived Products of [ 1111881-70-9 ]
Product Details of [ 1111881-70-9 ]
CAS No. : | 1111881-70-9 |
MDL No. : | MFCD28118237 |
Formula : |
C12H10F3N3O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
285.22
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1111881-70-9 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1111881-70-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1111881-70-9 ]
- 2
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[ 1111881-70-9 ]
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[ 222714-37-6 ]
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(S)-4-(1-(5-methyl-1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazole-4-carboxamido)ethyl)benzoic acid
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
2: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 70 °C / Inert atmosphere |
|
Reference:
[1]Yang, Jun-Jie; Yu, Wei-Wei; Hu, Long-Long; Liu, Wen-Juan; Lin, Xian-Hua; Wang, Wei; Zhang, Qiansen; Wang, Pei-Li; Tang, Shuo-Wen; Wang, Xin; Liu, Mingyao; Lu, Weiqiang; Zhang, Han-Kun
[Journal of Medicinal Chemistry, 2020, vol. 63, # 2, p. 569 - 590]
- 3
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[ 1111881-70-9 ]
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[ 222714-37-6 ]
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C22H21F3N4O3
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
76% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; |
|
Reference:
[1]Yang, Jun-Jie; Yu, Wei-Wei; Hu, Long-Long; Liu, Wen-Juan; Lin, Xian-Hua; Wang, Wei; Zhang, Qiansen; Wang, Pei-Li; Tang, Shuo-Wen; Wang, Xin; Liu, Mingyao; Lu, Weiqiang; Zhang, Han-Kun
[Journal of Medicinal Chemistry, 2020, vol. 63, # 2, p. 569 - 590]
- 4
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[ 402-49-3 ]
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[ 1111881-70-9 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: sodium azide / dimethyl sulfoxide / 20 °C / Inert atmosphere
2: toluene / 100 °C / Inert atmosphere
3: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 70 °C / Inert atmosphere |
|
Reference:
[1]Yang, Jun-Jie; Yu, Wei-Wei; Hu, Long-Long; Liu, Wen-Juan; Lin, Xian-Hua; Wang, Wei; Zhang, Qiansen; Wang, Pei-Li; Tang, Shuo-Wen; Wang, Xin; Liu, Mingyao; Lu, Weiqiang; Zhang, Han-Kun
[Journal of Medicinal Chemistry, 2020, vol. 63, # 2, p. 569 - 590]
- 5
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ethyl 5-methyl-1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazole-4-carboxylate
[ No CAS ]
-
[ 1111881-70-9 ]
Yield | Reaction Conditions | Operation in experiment |
98% |
With lithium hydroxide monohydrate In tetrahydrofuran; methanol; water at 70℃; Inert atmosphere; |
|
Reference:
[1]Yang, Jun-Jie; Yu, Wei-Wei; Hu, Long-Long; Liu, Wen-Juan; Lin, Xian-Hua; Wang, Wei; Zhang, Qiansen; Wang, Pei-Li; Tang, Shuo-Wen; Wang, Xin; Liu, Mingyao; Lu, Weiqiang; Zhang, Han-Kun
[Journal of Medicinal Chemistry, 2020, vol. 63, # 2, p. 569 - 590]
- 6
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[ 222716-19-0 ]
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[ 1111881-70-9 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: toluene / 100 °C / Inert atmosphere
2: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 70 °C / Inert atmosphere |
|
Reference:
[1]Yang, Jun-Jie; Yu, Wei-Wei; Hu, Long-Long; Liu, Wen-Juan; Lin, Xian-Hua; Wang, Wei; Zhang, Qiansen; Wang, Pei-Li; Tang, Shuo-Wen; Wang, Xin; Liu, Mingyao; Lu, Weiqiang; Zhang, Han-Kun
[Journal of Medicinal Chemistry, 2020, vol. 63, # 2, p. 569 - 590]
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