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Chemical Structure| 1117893-60-3 Chemical Structure| 1117893-60-3

Structure of 1117893-60-3

Chemical Structure| 1117893-60-3

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Product Details of [ 1117893-60-3 ]

CAS No. :1117893-60-3
Formula : C14H16N2O5
M.W : 292.29
SMILES Code : O=C1O[C@@H](CO)CN1C2=CC=C(N3CCOCC3=O)C=C2

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Application In Synthesis of [ 1117893-60-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1117893-60-3 ]

[ 1117893-60-3 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 1313613-18-1 ]
  • [ 60827-45-4 ]
  • [ 1117893-60-3 ]
YieldReaction ConditionsOperation in experiment
74.8% With lithium tert-butoxide; In tetrahydrofuran; at 30℃; for 24h; Example 2: Preparation of 4-(4-((R)-5-(hydroxymethyl)-2-oxo-oxazolidin-3- yl)phenyl)morpholin-3-one (Compound-V): 3.0g, (9.20 mmol) of [4-(3-oxo-morphoin-4-yl) phenyl] carbamic acid benzyl ester and 25 ml of anhydrous tetrahydrofuran (THF) were charged in a clean and dry R.B. flask. Lithium-t-butoxide in tetrahydrofuran (THF) (1.0 MjJ jnl^LS^-mmoO-was-added-drop^" wise followed by addition of S-(+)-3-chloro-l,2-propane diol (1.22g, 1 1 mmol) The resultant reaction mixture was stirred at about 30C for about 24hours. The reaction mixture was diluted by adding 20ml of saturated ammonium chloride solution and tetrahydrofuran (THF) was evaporated under reduced pressure. The aqeous phase was extracted with dichloromethane (5 X 20 ml). The combined organic phases were dried over anhydrous magnesium sulphate. The solvent was distilled completely at about 30C under vacuum. The crude obtained was suspended in 10 ml of ethyl acetate followed by heating to about reflux for about 30 min. The reaction suspension was cooled to about 30C. The solid separated was filtered and the solid was washed with 2 ml of ethyl acetate to afford the title compound as light brownish solid. Yield : 2.0 gms, (% Yield: 74.8%).
 

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