Alternatived Products of [ 111934-94-2 ]
Product Details of [ 111934-94-2 ]
CAS No. : | 111934-94-2 |
MDL No. : | MFCD20527801 |
Formula : |
C7H13BrO2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
209.08
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 111934-94-2 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 111934-94-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 111934-94-2 ]
- 1
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[ 4728-12-5 ]
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[ 111934-94-2 ]
Yield | Reaction Conditions | Operation in experiment |
100% |
With 1H-imidazole; carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20℃; for 4h;Cooling with ice; |
j0363] 2,2-Dimethyl-5-(hydroxymethyl)-1 ,3-dioxane (3a) (1.00 g) was dissolved in 22.8 mE of dichloromethane (MDC), and 700.0 mg of imidazole and 2.72 g of carbon tetrabromide were added thereto. After ice-cooling, 2.15 g of triphenylphosphine was thrther added, and the mixture was stirred at room temperature for 4 hours. Dichloromethane was distilled off under reduced pressure, and the resulting product was purified with silica gel chromatography (n-hexane:ethyl acetate=5: 1) to quantitatively obtain 1.60 g of 2,2-dimethyl-5-bromomethyl- 1 ,3-dioxane (Sb). |
Reference:
[1]Patent: US2017/233421,2017,A1 .Location in patent: Paragraph 0362; 0363
[2]Journal of the American Chemical Society,1987,vol. 109,p. 8071 - 8081
[3]Journal of Medicinal Chemistry,2005,vol. 48,p. 5980 - 5988
[4]Tetrahedron,1991,vol. 47,p. 1001 - 1012
[5]ACS Medicinal Chemistry Letters,2010,vol. 1,p. 321 - 325
[6]Patent: US2017/233421,2017,A1
- 2
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[ 111934-95-3 ]
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[ 111934-94-2 ]
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[ 111934-96-4 ]
Yield | Reaction Conditions | Operation in experiment |
27% |
With tert.-butyl lithium In diethyl ether 1.) -78 deg C, 12 min; 2.) 15 min; |
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- 3
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[ 51335-75-2 ]
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[ 111934-94-2 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: 72 percent / 4 h / Heating
2: 82 percent / LiAlH4
3: 71 percent / pyridine, triphenylphosphine, carbon tetrabromide / CH2Cl2 / 2.5 h |
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Multi-step reaction with 4 steps
1: 65 percent / NaCl / H2O; dimethylsulfoxide / 6 h / Heating
2: 99 percent / LiAlH4 / diethyl ether / 2.5 h / Ambient temperature
3: triethylamine / 2.5 h / 0 °C
4: 24 percent / nBu4NBr / acetone / 1.5 h / Heating |
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Reference:
[1]Yuan, Wei; Berman, Richard J.; Gelb, Michael H.
[Journal of the American Chemical Society, 1987, vol. 109, # 26, p. 8071 - 8081]
[2]Dubois, Joelle; Foures, Christine; Bory, Sonia; Falcou, Serge; Gaudry, Michel; Marquet, Andree
[Tetrahedron, 1991, vol. 47, # 6, p. 1001 - 1012]
- 4
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[ 82962-54-7 ]
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[ 111934-94-2 ]