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Chemical Structure| 1139717-76-2 Chemical Structure| 1139717-76-2

Structure of 1139717-76-2

Chemical Structure| 1139717-76-2

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Product Details of [ 1139717-76-2 ]

CAS No. :1139717-76-2
Formula : C11H17BN2O2
M.W : 220.08
SMILES Code : CN1CCN(C2=CC(B(O)O)=CC=C2)CC1
MDL No. :MFCD13194680
InChI Key :HXGDRMHRVSAMGD-UHFFFAOYSA-N
Pubchem ID :57830753

Safety of [ 1139717-76-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1139717-76-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1139717-76-2 ]

[ 1139717-76-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1139717-76-2 ]
  • [ 4983-28-2 ]
  • [ 1350660-04-6 ]
YieldReaction ConditionsOperation in experiment
41% With copper diacetate; triethylamine; In dichloromethane; Intermediate 16: l-[3-(2-Chloropyrimidin-5-yloxy)phenyl]-4-methylpiperazineA mixture of <strong>[4983-28-2]2-chloro-5-hydroxypyrimidine</strong> (0.71 lg, 0.00545mol), 3-(4-methyl- piperazin-l-yl)phenyl boronic acid (1.5g, 0.00545mol), copper (II) acetate (0.99g,0.00545mol), triethylamine (3.8mL, 0.0272mol) and powdered 4A molecular sieves in dichloromethane (40mL) was stirred under air for 3 days. The suspension was diluted with dichloromethane, filtered and washed with water and brine. The organic phase was dried (MgS04) and the solvent removed under reduced pressure. The crude product was purified by column chromatography on silica eluting with dichloromethane:methanol (19:1) to afford l-[3-(2-chloropyrimidin-5-yloxy)phenyl]- 4-methylpiperazine (0.68g, 41percent) as colourless oil.Mass: (ES+) 305 (M+H) +
 

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