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Chemical Structure| 1142194-24-8 Chemical Structure| 1142194-24-8

Structure of 1142194-24-8

Chemical Structure| 1142194-24-8

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Product Details of [ 1142194-24-8 ]

CAS No. :1142194-24-8
Formula : C8H10BrNO
M.W : 216.08
SMILES Code : CC(OC1=NC=CC(Br)=C1)C
MDL No. :MFCD11869614
InChI Key :DGDIOQCZNZMIPA-UHFFFAOYSA-N
Pubchem ID :45787897

Safety of [ 1142194-24-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1142194-24-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1142194-24-8 ]

[ 1142194-24-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1142194-24-8 ]
  • [ 4522-35-4 ]
  • [ 1621525-13-0 ]
YieldReaction ConditionsOperation in experiment
INTERMEDIATE 21 4-(3 -Iodo- 1 H-pyrazol- 1 -ylV2-isopropoxypyridine To a solution of <strong>[4522-35-4]3-iodopyrazole</strong> (0.30 g, 1.547 mmol) in DMSO (7.73 mL) was added sodium hydride (60% in oil, 0.068 g, 1.701 mmol). The resulting mixture was stirred for 0.5 h before 4-bromo-2-isopropoxypyridine (0.334 g, 1.547 mmol) was added. The reaction mixture was stirred at 80 C overnight. The reaction was quenched by the addition of water and extracted with EtOAc. The combined organic extracts were washed with water and brine, dried over MgS04 and concentrated in vacuo. The crude mixture was purified by flash chromatography (ISCO Combiflash, 24 g, 0-10 % EtOAc in hexanes) to give 4-(3 -iodo- 1 H-pyrazol- l-yl)-2-isopropoxypyridine, as a white solid. LCMS calc. = 330.00; found = 329.91. (Mu+Eta)+. NMR (500 MHz, CDC13): 5 8.17 (d, J= 5.7 Hz? 1 H); 7.78 (d, J= 2.6 Hz, 1 H); 7.20 (dd, J= 5.7, 1.9 Hz, 1 H); 6.93 (d, J= 1.9 Hz, 1 H); 6.64 (d, J= 2.5 Hz, 1 H); 5.34 (m, 1 H); 1.36 (d, J = 6.2 Hz, 6 H).
 

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