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[ CAS No. 1146629-77-7 ]

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Chemical Structure| 1146629-77-7
Chemical Structure| 1146629-77-7
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CAS No. :1146629-77-7 MDL No. :N/A
Formula : C15H17N5O2 Boiling Point : 536.7±50.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :299.33 g/mol Pubchem ID :57868869
Synonyms :

Safety of [ 1146629-77-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1146629-77-7 ]

  • Upstream synthesis route of [ 1146629-77-7 ]
  • Downstream synthetic route of [ 1146629-77-7 ]

[ 1146629-77-7 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 269410-08-4 ]
  • [ 1146629-75-5 ]
  • [ 1146629-77-7 ]
YieldReaction ConditionsOperation in experiment
82.27% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water for 14 h; Heating (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate (10 g; Formula V), water (50 mL), and potassium carbonate (15.5 g) were added into a reaction vessel at ambient temperature. 4-(4,4,5,5-Tetramethyl-l,3,2-dioxaborolan-2-yl)-lH- pyrazole (8.7 g; Formula VIII), 1,4-dioxane (100 mL), and tetrakis(triphenylphosphine)palladium(0) (0.08 g) were added to the reaction mixture. The reaction mixture was heated to a temperature of 80°C to 85°C, and then stirred at the same temperature for 14 hours. The progress of the reaction was monitored by thin layer chromatography. On completion, ethyl acetate (100 mL) was added to the reaction mixture. The contents were stirred for 1 hour,then filtered through a Hyflo, and then washed with ethyl acetate (40 mL). The organic layer was separated, and then concentrated under reduced pressure to obtain [4-(lH-pyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-7-yl]methyl pivalate. Yield: 82.27percent
Reference: [1] Patent: WO2016/88094, 2016, A1, . Location in patent: Page/Page column 10
  • 2
  • [ 1146629-76-6 ]
  • [ 1146629-77-7 ]
Reference: [1] Organic Letters, 2009, vol. 11, # 9, p. 1999 - 2002
[2] Patent: US2009/233903, 2009, A1, . Location in patent: Page/Page column 68
[3] Patent: US2010/190981, 2010, A1, . Location in patent: Page/Page column 52-53
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