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[ CAS No. 114676-61-8 ]

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Chemical Structure| 114676-61-8
Chemical Structure| 114676-61-8
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Product Details of [ 114676-61-8 ]

CAS No. :114676-61-8 MDL No. :MFCD11111254
Formula : C10H19NO3 Boiling Point : 282.5±33.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :201.26 g/mol Pubchem ID :11008972
Synonyms :

Safety of [ 114676-61-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280 UN#:N/A
Hazard Statements:H302-H317 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 114676-61-8 ]

  • Upstream synthesis route of [ 114676-61-8 ]
  • Downstream synthetic route of [ 114676-61-8 ]

[ 114676-61-8 ] Synthesis Path-Upstream   1~13

  • 1
  • [ 83220-73-9 ]
  • [ 77-78-1 ]
  • [ 114676-93-6 ]
  • [ 114676-61-8 ]
Reference: [1] Chemical Communications, 1998, # 16, p. 1723 - 1724
[2] Chemical Communications, 1998, # 16, p. 1723 - 1724
  • 2
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YieldReaction ConditionsOperation in experiment
99% With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; (2S,4R)-tert-butyl 4-((tert-butyldimethyl silicon)-oxy)2-methylpyrrolidine-1-carboxylate (2.2 g, 6.98 mmol) is dissolved in THF (30 mL), followed by adding tetrabutylammonium fluoride (3.65 g, 14.0 mmol), and the reaction mixture reacts overnight at room temperature.
Then the reaction mixture is poured into water (60 mL), and extracted with ethyl acetate (60 mL * 2), washed with saturated salt solution (60 mL * 2), dried with anhydrous Na2SO4, rotated to dryness and purified by column chromatography (PE : EA = 2 : 1), so as to obtain a yellow oily matter of 1.47 g, that is (2S,4R)-tert-butyl 4-hydroxyl-2-methylpyrrolidine-1-carboxylate with a yield of 99percent.
Reference: [1] Patent: EP3401315, 2018, A1, . Location in patent: Paragraph 0106; 0111
[2] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
[3] Journal of the American Chemical Society, 2008, vol. 130, # 3, p. 875 - 886
  • 3
  • [ 114676-58-3 ]
  • [ 114676-61-8 ]
Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
[2] Patent: EP3401315, 2018, A1,
  • 4
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  • [ 114676-61-8 ]
Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
  • 5
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Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
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Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
  • 7
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Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
  • 8
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Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
  • 9
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  • [ 114676-61-8 ]
Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
  • 10
  • [ 83220-73-9 ]
  • [ 77-78-1 ]
  • [ 114676-93-6 ]
  • [ 114676-61-8 ]
Reference: [1] Chemical Communications, 1998, # 16, p. 1723 - 1724
[2] Chemical Communications, 1998, # 16, p. 1723 - 1724
  • 11
  • [ 114676-91-4 ]
  • [ 114676-61-8 ]
Reference: [1] Patent: EP3401315, 2018, A1,
  • 12
  • [ 114676-92-5 ]
  • [ 114676-61-8 ]
Reference: [1] Patent: EP3401315, 2018, A1,
  • 13
  • [ 114676-61-8 ]
  • [ 477293-60-0 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 19, p. 2733 - 2736
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