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[ CAS No. 1147558-43-7 ]

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Chemical Structure| 1147558-43-7
Chemical Structure| 1147558-43-7
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CAS No. :1147558-43-7 MDL No. :MFCD18426013
Formula : C7H4ClFN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :170.57 g/mol Pubchem ID :68039995
Synonyms :

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Signal Word:Warning Class:
Precautionary Statements:P280-P305+P351+P338 UN#:
Hazard Statements:H302 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1147558-43-7 ]

  • Upstream synthesis route of [ 1147558-43-7 ]
  • Downstream synthetic route of [ 1147558-43-7 ]

[ 1147558-43-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 63069-50-1 ]
  • [ 1147558-43-7 ]
YieldReaction ConditionsOperation in experiment
88% With N-chloro-succinimide In acetonitrile at 85℃; for 5 h; 4-Amino-3-chloro-5-fluorobenzonitrile
A mixture of 4-amino-3-fluorobenzonitrile (1 equiv.) and N-chlorosuccinimide (1.5 equiv.) in acetonitrile (0.24 M) was stirred at 85° C. for 5 h.
The solvent was removed by concentration and the residue was partitioned between ethyl acetate and 5percent NaOH.
The organic phase was washed with 5percent NaOH and brine.
Then the organic phase was dried over MgSO4 and dried in vacuum to afford 4-amino-3-chloro-5-fluorobenzonitrile (88percent) as a beige solid. 1H NMR (400 MHz, CDCl3) δ ppm: 7.41 (t, J=6 Hz, 1H), 7.24 (dd, J=1.8, 10.2 Hz, 1H), 4.66 (s, 2H).
Reference: [1] Patent: US2016/96841, 2016, A1, . Location in patent: Paragraph 0281
[2] Patent: WO2012/174342, 2012, A1, . Location in patent: Page/Page column 45
[3] Patent: WO2013/12500, 2013, A1, . Location in patent: Page/Page column 61
[4] Patent: US2015/203455, 2015, A1, . Location in patent: Paragraph 0457-0458
[5] Patent: WO2015/110378, 2015, A1, . Location in patent: Paragraph 00260; 00312
[6] Patent: US9440929, 2016, B2, . Location in patent: Page/Page column 59
[7] Patent: WO2017/12647, 2017, A1, . Location in patent: Paragraph 0688
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