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[ CAS No. 114873-00-6 ]

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Chemical Structure| 114873-00-6
Chemical Structure| 114873-00-6
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Product Details of [ 114873-00-6 ]

CAS No. :114873-00-6 MDL No. :MFCD00672520
Formula : C14H18FNO4 Boiling Point : 427.3°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :283.30 g/mol Pubchem ID :2734496
Synonyms :

Safety of [ 114873-00-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
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Application In Synthesis of [ 114873-00-6 ]

  • Upstream synthesis route of [ 114873-00-6 ]
  • Downstream synthetic route of [ 114873-00-6 ]

[ 114873-00-6 ] Synthesis Path-Upstream   1~2

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  • [ 19883-78-4 ]
  • [ 114873-00-6 ]
YieldReaction ConditionsOperation in experiment
85% With sodium hydroxide In water EXAMPLE 39
N-Z-N'-{N-(2S,3S)-trans-ethoxycarbonyloxirane-2-carbonyl]-o-fluoro-L-phenylalanyl}-1,4-diaminobutane
In a mixture of dioxanes (10 ml) and water (5 ml), o-fluoro-L-phenylalanine (1.00 g, manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved.
To the solution were added, while stirring under ice-cooling conditions, a 1N aqueous solution of sodium hydroxide (5.46 ml) and di-tert-butyl dicarbonate (1.38 ml), followed by stirring for one hour at room temperature.
The reaction mixture was concentrated, then the pH was adjusted to 2.5, followed by extraction with ethyl acetate (100 ml *3).
The ethyl acetate layer was washed with water and a saturated saline, dried over anhydrous sodium sulfate.
After concentration, the concentrate was crystallized from ethyl acetate--petroleum ether to yield N-Boc-o-fluoro-L-phenylalanine (1.32 g) as colorless crystals (yield 85percent).
Reference: [1] Patent: US5556853, 1996, A,
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099
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  • [ 58632-95-4 ]
  • [ 19883-78-4 ]
  • [ 114873-00-6 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1989, vol. 37, # 3, p. 826 - 828
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