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[ CAS No. 114873-02-8 ]

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Chemical Structure| 114873-02-8
Chemical Structure| 114873-02-8
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Product Details of [ 114873-02-8 ]

CAS No. :114873-02-8 MDL No. :MFCD00672514
Formula : C14H18ClNO4 Boiling Point : 452.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :299.75 g/mol Pubchem ID :2761463
Synonyms :

Safety of [ 114873-02-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 114873-02-8 ]

  • Downstream synthetic route of [ 114873-02-8 ]

[ 114873-02-8 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 98946-18-0 ]
  • [ 114873-02-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; cyclohexane at 20℃; for 48h;
  • 2
  • [ 108-00-9 ]
  • [ 114873-02-8 ]
  • [ 608527-07-7 ]
YieldReaction ConditionsOperation in experiment
66% With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;
  • 3
  • [ 342395-22-6 ]
  • [ CAS Unavailable ]
  • [ CAS Unavailable ]
  • [ 114873-02-8 ]
  • [ 343833-77-2 ]
YieldReaction ConditionsOperation in experiment
Stage #1: 1-(6-phenylhexyl)-4-piperidone; Rink-isonitrile resin; propylamine; Nα-[(tert-butoxy)carbonyl]-2-(chloro)-L-phenylalanine In tetrahydrofuran; methanol; chloroform at 65℃; for 18h; Stage #2: With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.5h; Stage #3: With acetic acid In toluene at 90℃; for 16h;
  • 4
  • [ 114873-02-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: CH2Cl2; cyclohexane / 48 h / 20 °C 2: HCl / dioxane; ethyl acetate / 20 °C
  • 5
  • [ 114873-02-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: CH2Cl2; cyclohexane / 48 h / 20 °C 2: HCl / dioxane; ethyl acetate / 20 °C 3: HOBt; TEA; EDC / CH2Cl2 / 20 °C
  • 6
  • [ 114873-02-8 ]
  • [ 944470-58-0 ]
YieldReaction ConditionsOperation in experiment
75% Stage #1: Nα-[(tert-butoxy)carbonyl]-2-(chloro)-L-phenylalanine With borane-THF In tetrahydrofuran at 0℃; for 3.5h; Stage #2: With acetic acid In tetrahydrofuran; methanol 22a.A To a stirred solution at 0° C of 16.74 ml Of BH3 in THF (1.0 M solution, 16.74 mmol) is added (S)-Boc-2-chloro-phenylalanine (2508 mg, 8.37 mmol) in 5 ml dry THF over 30 minutes. The reaction is held at 0° C for 3 hours and then stopped with 25 ml of 10% acetic acid in methanol. The solution is concentrated in vacuo and the residue is dissolved in 100 ml ethyl acetate and washed with 100 ml of IN HCl, water, and IMNH4HCO3. The organic layer is dried over MgSO4 and concentrated in vacuo to provide tert- butyl [(lS)-l-(2-chlorobenzyl)-2-hydroxyethyl]carbamate (1.790 g, 75%). MS: 330.0[M+FA-H].
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