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CAS No. : | 115016-95-0 | MDL No. : | MFCD06656492 |
Formula : | C10H12O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 180.20 | Pubchem ID : | - |
Synonyms : |
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.3 |
Num. rotatable bonds : | 4 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 48.76 |
TPSA : | 57.53 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.45 cm/s |
Log Po/w (iLOGP) : | 1.31 |
Log Po/w (XLOGP3) : | 1.34 |
Log Po/w (WLOGP) : | 1.06 |
Log Po/w (MLOGP) : | 1.41 |
Log Po/w (SILICOS-IT) : | 1.46 |
Consensus Log Po/w : | 1.32 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -1.88 |
Solubility : | 2.38 mg/ml ; 0.0132 mol/l |
Class : | Very soluble |
Log S (Ali) : | -2.15 |
Solubility : | 1.28 mg/ml ; 0.00708 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.05 |
Solubility : | 1.59 mg/ml ; 0.00885 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.61 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302+H312+H332-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With sulfuric acid; at 20℃; for 24.0h;Sealed tube; Inert atmosphere; | To a 50 mL seal tub charge with <strong>[115016-95-0](S)-2-hydroxy-4-phenylbutanoic acid</strong> 4c63 mg, 0.35 mmolinargon environment, was added 10% H2SO4/EtOH solution at ice bath. Subsequently, the reactionwas stirred at room temperature for 24 h. Then EtOH was removed in vacuo, then water was addedand extracted with ethyl acetate (3×10 mL). The organic phase was washed with brine, dried overNa2SO4, purified by flash chromatography (ether/ethyl acetate = 10:1), affording 5c (60 mg, 82 %yield, 99% ee) [9]. |
With sulfuric acid; | (S)-2-Hydroxy-4-phenylbutanoic acid (F. Nerdel and H. Rachel, Chem. Ber. 1956, 89, 671) was esterified in the usual manner using ethanol and a small amount of sulfuric acid as described for the (R)-enantiomer (M. R. Attwood, C. H. Hassall, A. Krohn, G. Lawton, R. Radshaw, J. C. S. Perkin 1, 1986, 1011) with passage of the returned ethanol over a bed of molecular sieves. The resulting ethyl ester had b.p. 95-97 C./0.03 mmHg and showed [alpha]25+8.75 (e.e. 88%). | |
With sulfuric acid; for 5.0h;Inert atmosphere; Reflux; | General procedure: The catalyst [RuCl(benzene)(S)-SunPhos]Cl (40 mg, 0.04 mmol) was dissolved in degassed THF (40 mL) containing 1 M of aq HBr (480 muL), and then the solution was put into eight vials equally. To these vials 2-oxo-4-arylbutanoic acids 1 (1 mmol) were introduced, and then the vials were taken into an autoclave. The autoclave was purged three times with H2, and the pressure of H2 was set to 400 psi. The autoclave was stirred under specified reaction conditions. After being cooled to ambient temperature and release of hydrogen, the autoclave was opened and the solvent was evaporated. The residue 2 were refluxed in EtOH with a drop of concentrated sulfuric acid for 5 h, and the corresponding esters were passed through a short pad of silica gel with petroleum ether and ethyl acetate before the ees were determined by HPLC. |
With sulfuric acid; for 4.0h;Reflux; | To a solution of 14a (4.25 g, 23.59 mmol) in anhyrous ethanol 125 mL was added concentrated H2SO4 (1,5 mL). The reaction mixture was stirred under reflux for 4 hours and evaporated under reduced pressure to remove excees ethanol. The residue was partitioned between water (50 mL) and ethylacetate (200 mL). The organic layer was washed with saturated NaHCO3 solution, brine, dried over anhyrous Na2SO4, filtered and evaporated in vacuo to give the crude ester product as a light yellow oil. The crude product was directly subjected to the reduction reaction without characterization. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen bromide; hydrogen; In tetrahydrofuran; water; at 70℃; under 20686.5 Torr; for 20h;Autoclave; | General procedure: The catalyst [RuCl(benzene)(S)-SunPhos]Cl (40 mg, 0.04 mmol) was dissolved in degassed THF (40 mL) containing 1 M of aq HBr (480 muL), and then the solution was put into eight vials equally. To these vials 2-oxo-4-arylbutanoic acids 1 (1 mmol) were introduced, and then the vials were taken into an autoclave. The autoclave was purged three times with H2, and the pressure of H2 was set to 400 psi. The autoclave was stirred under specified reaction conditions. After being cooled to ambient temperature and release of hydrogen, the autoclave was opened and the solvent was evaporated. The residue 2 were refluxed in EtOH with a drop of concentrated sulfuric acid for 5 h, and the corresponding esters were passed through a short pad of silica gel with petroleum ether and ethyl acetate before the ees were determined by HPLC. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen; In tetrahydrofuran; water; at 70℃; under 20686.5 Torr; for 12.0h;Autoclave; | General procedure: The catalyst [RuCl(benzene)(S)-SunPhos]Cl (40 mg, 0.04 mmol) was dissolved in degassed THF (40 mL) containing 1 M of aq HBr (480 muL), and then the solution was put into eight vials equally. To these vials 2-oxo-4-arylbutanoic acids 1 (1 mmol) were introduced, and then the vials were taken into an autoclave. The autoclave was purged three times with H2, and the pressure of H2 was set to 400 psi. The autoclave was stirred under specified reaction conditions. After being cooled to ambient temperature and release of hydrogen, the autoclave was opened and the solvent was evaporated. The residue 2 were refluxed in EtOH with a drop of concentrated sulfuric acid for 5 h, and the corresponding esters were passed through a short pad of silica gel with petroleum ether and ethyl acetate before the ees were determined by HPLC. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | EXAMPLE 27 (S)-2-Hydroxy-4-phenylbutyric Acid, ethyl ester To a suspension of potassium cyanide (0. 176 g, 2.70 mmole) in absolute ethanol (43 mL) was added a solution of (S)-2-[4-nitrobenzoyl]-4-phenylbutyric acid, ethyl ester (3.86 g, 10.8 mmole) in absolute ethanol (38 mL) dropwise over a period of 0.5 hours. After stirring 2.25 hours the solvent was removed and the reside was diluted with water and acidified with dilute hydrochloric acid. The organics were extracted with ether. The extracts were combined, silica gel (60 mL) was added and the solvent was removed. The adsorbate was flash chromatographed, eluent (gradient 90/10-80/20 petroleum ether/ethyl acetate) and the solvents were chased with benzene to give the title compound as a yellow oil (1.67 g, 74%): NMR (CDCl3); delta7.38-7.16 (m, 5H), 4.30-4.10(m, 3H), 2.9-2.6 (m, 3H,), 2.2-1.9(m, 2H), 1.15(t, 4 Hz, 3H); [a]25D +178.23 at 10.98 mg/mL CHCl3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With immobilized lipase from Candida rugosa; In aq. buffer;Resolution of racemate; Enzymatic reaction; | The enzymatic hydrolysis of rac-3 was carried out according to a previous report [43]. A suspension of CLEA (300-400 g of protein) or immobilized derivative (500 mg) in 3 mL of 5 mM of rac-3 in 5 mM of buffered solution (10 mM of sodium acetate or sodium phosphate, for pH 7 or pH 5, respectively) was prepared.The reaction mixture was maintained under gentle agitation (at 25 or 4C) until the achievement of 10-15% of substrate hydrolysis degree. Hydrolysis degree was determined by HPLC (Spectra System P4000) coupled to an UV-diode array detector (Spectra SystemSN4000) with a Kromasil C18 (25 cm × 0.4 cm) reverse phase column. The elution of compounds was done with an isocratic mobilephase of ammonium acetate buffered solution (10 mM and pH 2.3)in an acetonitrile/water mixture (40:60 v/v) and a constant flow of1.0 mL/min. Analytes were detected at 225 nm with retention times of 3.2 and 10.2 min for the product, racemic hydroxy-phenylbutyricacid (rac-4) and the substrate (rac-3), respectively. One unit of activity was defined as the amount of enzyme needed for release one mol of (R)- or (S)-4 per minute. The conversion degree was estimated after relationship of the peak?s area and a calibration curvein the same elution conditions.The ee of released (R)-3 was determined by reverse chiral HPLC(Spectra System P4000) coupled with an UV-diode array detector(Spectra System SN4000) and a Chiralcel OD-R (250 mm × 4.6 mm)column. Samples with 10-15% of substrate?s hydrolysis degree were analyzed in order to ensure a first-order enzyme kinetic. HPBEenantiomers were eluted with an isocratic mobile phase of ammonium phosphate buffer (10 mM at pH 2.3) in an acetonitrile/water mixture (20:80, v/v) and a flow of 0.5 mL/min. Enantiomers weredetected at 225 nm with retention times of 23.1 and 25.3 min for(S)- and (R)-3, respectively. Enantioselectivity was calculated withChen equation [38]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With chiral spiro phosphine Iridium complex; In ethanol; at 20℃; under 11400.8 Torr; for 10.0h; | General procedure: Under nitrogen, the inner tube was added 200mL hydrogenation a- keto acid substrate 2a (3g, 20mmol), potassium tert-butoxide (112 mg, 1mmol), catalyst M (20mg, 0.02mmol, R = 3- methyl ) and a solvent (50mL). The inside of the reaction tube into the autoclave. After the replacement with hydrogen gas in the autoclave, an initial charge to 15 atmospheres hydrogen pressure, and allowed the reaction was stirred at room temperature for 24 hours. The hydrogenation reaction, hydrogen was released, the autoclave was opened. The reaction mixture was filtered to remove the catalyst by rapid short silica gel using NMR analysis of the reaction conversion |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | With water; hydrogen bromide; at 120℃; for 12.0h;Inert atmosphere; | To a 50 mL seal tube charged with (S)-N-(tert-butyl)-2-hydroxy-4-phenylbutan-amide 3c120 mg,0.51 mmol, 99% eeat argon environment, was added 48% HBr aqueous solution (2 mL).Subsequently, heated to 120 C and stirred at this temperature for 12 h. Then water was added to thereaction mixture, and extracted with diethyl ether ( 3×20 mL), the organic phase was washed withbrine, dried over Na2SO4, purified by flash chromatography (petroleum ether/EtOAc = 1:1),affording 4c (91.8 mg, 68% yield). |
68% | With hydrogen bromide; In water; at 120℃; for 12.0h;Sealed tube; Inert atmosphere; | A 48% aqueous solution of HBr (2 mL) was added to a 50 mL sealed tube containing 3c (120 mg, 0.51 mmol, 99% ee) under argon.Subsequently, it was heated to 120 C and stirred at this temperature for 12 hours.Water was then added to the reaction mixture, which was extracted with diethyl ether (3×20 mL).Dry with Na2SO4,Purified by column chromatography (petroleum ether / EtOAc = 1:1).4c (91.8 mg, yield 68%) was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With sulfuric acid; In ethanol; at 20℃; for 24.0h;Sealed tube; Inert atmosphere; | A 10% H2SO4/EtOH solution was added to a 50 mL sealed tube of 4c (63 mg, 0.35 mmol) under argon.Subsequently, the reaction was stirred at room temperature for 24 hours.EtOH was then removed in vacuo then water was added and extracted with ethyl acetate (3×10 mL).The organic phase was washed with brine and dried over Na 2 SO 4Purified by column chromatography (diethyl ether / ethyl acetate = 10:1)5c (60 mg, 82% yield, 98.5% ee). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride In water | General procedures for enantioseparation of 2-hydroxy-4-phenylbutyric acid by (1R,2S)-2-amino-1,2-diphenylethanol (ADPE) General procedure: Rac-HPBA (1.00 mmol) and (1R,2S)-ADPE (1.00 mmol) were dissolved in methanol. After concentration, the resulting white solids were recrystallized from an appropriate solvent to obtain the salt crystals, which were filtered and dried under reduced pressure. The yield was calculated based on the 1H NMR data, considering the amount of the included solvent. A portion of the salt (ca. 20 mg) was decomposed by the addition of 1 M aqueous HCl solution and the aqueous layer was extracted with diethyl ether. After drying over anhydrous Na2SO4, the organic layer was concentrated to obtain enantio-enriched HPBA. To a solution of HPBA in methanol (1 ml) was added TMSCHN2 (hexane or ether solution) until the solution remained yellow. The mixture was stirred for 30 min at room temperature and the solvent was removed under reduced pressure. The residue was purified by silica gel PTLC (hexane/ethyl acetate = 2 :1) to produce methyl ester of HPBA. The ee value of the ester was determined by chiral HPLC analysis (Daicel Chiralcel OD-3, hexane/2-propanol=90:10, 1.0 mL/min; tr(S) = 8.3 min, tr(R) = 11.3 min). Methyl ester of (S)-HPBA: 1H NMR (400 MHz, CDCl3): δ (ppm) 7.35-7.10 (m, 5H), 4.25-4.15 (m, 1H), 3.75 (s, 3H), 2.85-2.65 (m, 3 H), 2.20-1.85 (m, 2H). 13C NMR (100 MHz, CDCl3): δ (ppm) 175.6, 141.1, 128.6, 128.4, 126.1, 69 .7, 52.6, 35.9, 31.0. Methyl ester of (R)-HPBA: 1H NMR (400 MHz, CDCl3): δ (ppm) 7.35-7.10 (m, 5H), 4.25-4.15 (m, 1H), 3.74 (s, 3H), 2.90-2.6 5 (m, 3 H), 2.20-1.85 (m, 2H). 13C NMR (100 MHz, CDCl3): δ (ppm) 175.6, 141.1, 128.6 128.4, 126.1, 69.7, 52.5, 35.9, 31.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol at 20℃; for 0.5h; | General procedures for enantioseparation of 2-hydroxy-4-phenylbutyric acid by (1R,2S)-2-amino-1,2-diphenylethanol (ADPE) General procedure: Rac-HPBA (1.00 mmol) and (1R,2S)-ADPE (1.00 mmol) were dissolved in methanol. After concentration, the resulting white solids were recrystallized from an appropriate solvent to obtain the salt crystals, which were filtered and dried under reduced pressure. The yield was calculated based on the 1H NMR data, considering the amount of the included solvent. A portion of the salt (ca. 20 mg) was decomposed by the addition of 1 M aqueous HCl solution and the aqueous layer was extracted with diethyl ether. After drying over anhydrous Na2SO4, the organic layer was concentrated to obtain enantio-enriched HPBA. To a solution of HPBA in methanol (1 ml) was added TMSCHN2 (hexane or ether solution) until the solution remained yellow. The mixture was stirred for 30 min at room temperature and the solvent was removed under reduced pressure. The residue was purified by silica gel PTLC (hexane/ethyl acetate = 2 :1) to produce methyl ester of HPBA. The ee value of the ester was determined by chiral HPLC analysis (Daicel Chiralcel OD-3, hexane/2-propanol=90:10, 1.0 mL/min; tr(S) = 8.3 min, tr(R) = 11.3 min). Methyl ester of (S)-HPBA: 1H NMR (400 MHz, CDCl3): δ (ppm) 7.35-7.10 (m, 5H), 4.25-4.15 (m, 1H), 3.75 (s, 3H), 2.85-2.65 (m, 3 H), 2.20-1.85 (m, 2H). 13C NMR (100 MHz, CDCl3): δ (ppm) 175.6, 141.1, 128.6, 128.4, 126.1, 69 .7, 52.6, 35.9, 31.0. Methyl ester of (R)-HPBA: 1H NMR (400 MHz, CDCl3): δ (ppm) 7.35-7.10 (m, 5H), 4.25-4.15 (m, 1H), 3.74 (s, 3H), 2.90-2.6 5 (m, 3 H), 2.20-1.85 (m, 2H). 13C NMR (100 MHz, CDCl3): δ (ppm) 175.6, 141.1, 128.6 128.4, 126.1, 69.7, 52.5, 35.9, 31.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride In water | General procedures for enantioseparation of 2-hydroxy-4-phenylbutyric acid by (1R,2S)-2-amino-1,2-diphenylethanol (ADPE) General procedure: Rac-HPBA (1.00 mmol) and (1R,2S)-ADPE (1.00 mmol) were dissolved in methanol. After concentration, the resulting white solids were recrystallized from an appropriate solvent to obtain the salt crystals, which were filtered and dried under reduced pressure. The yield was calculated based on the 1H NMR data, considering the amount of the included solvent. A portion of the salt (ca. 20 mg) was decomposed by the addition of 1 M aqueous HCl solution and the aqueous layer was extracted with diethyl ether. After drying over anhydrous Na2SO4, the organic layer was concentrated to obtain enantio-enriched HPBA. To a solution of HPBA in methanol (1 ml) was added TMSCHN2 (hexane or ether solution) until the solution remained yellow. The mixture was stirred for 30 min at room temperature and the solvent was removed under reduced pressure. The residue was purified by silica gel PTLC (hexane/ethyl acetate = 2 :1) to produce methyl ester of HPBA. The ee value of the ester was determined by chiral HPLC analysis (Daicel Chiralcel OD-3, hexane/2-propanol=90:10, 1.0 mL/min; tr(S) = 8.3 min, tr(R) = 11.3 min). Methyl ester of (S)-HPBA: 1H NMR (400 MHz, CDCl3): δ (ppm) 7.35-7.10 (m, 5H), 4.25-4.15 (m, 1H), 3.75 (s, 3H), 2.85-2.65 (m, 3 H), 2.20-1.85 (m, 2H). 13C NMR (100 MHz, CDCl3): δ (ppm) 175.6, 141.1, 128.6, 128.4, 126.1, 69 .7, 52.6, 35.9, 31.0. Methyl ester of (R)-HPBA: 1H NMR (400 MHz, CDCl3): δ (ppm) 7.35-7.10 (m, 5H), 4.25-4.15 (m, 1H), 3.74 (s, 3H), 2.90-2.6 5 (m, 3 H), 2.20-1.85 (m, 2H). 13C NMR (100 MHz, CDCl3): δ (ppm) 175.6, 141.1, 128.6 128.4, 126.1, 69.7, 52.5, 35.9, 31.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
15% | With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; | General procedure for the synthesis of 2-hydroxy acylhomoserinelactones (step B): General procedure: To a solution of 2-hydroxy carboxylic acid (0.5 mmol) and L-α-amino-γ-butyrolactone hydrobromide (0.6 mmol) in CH2Cl2 (4 mL)were added triethylamine (1.1 mmol) and 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (EDC) (0.55 mmol) and 1-hydroxybenzotriazole(HOBt) (0.5 mmol) at 0. The reaction mixture wasstirred for 1 h at 0 and overnight at room temperature. The solventwas evaporated and EtOAc (20 mL) was added. The mixture was washedsuccessively with brine, 1% HCl, 5% NaHCO3, and brine, dried over anhydrous Na2SO4, concentrated and purified by flash chromatographyto get the desired product. |
Tags: 115016-95-0 synthesis path| 115016-95-0 SDS| 115016-95-0 COA| 115016-95-0 purity| 115016-95-0 application| 115016-95-0 NMR| 115016-95-0 COA| 115016-95-0 structure
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P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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