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[ CAS No. 1151564-10-1 ] {[proInfo.proName]}

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Chemical Structure| 1151564-10-1
Chemical Structure| 1151564-10-1
Structure of 1151564-10-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1151564-10-1 ]

CAS No. :1151564-10-1 MDL No. :
Formula : C11H13FO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 228.22 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1151564-10-1 ]

[ 1151564-10-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 924-44-7 ]
  • [ 321-28-8 ]
  • [ 1151564-10-1 ]
YieldReaction ConditionsOperation in experiment
85% (1) 1.0 g, 1 equiv. of the compound of formula II was dissolved in a constant pressure dropping funnel using 5 mL of THF, and a solution of 1.6 equiv. of diisopropylamino lithium in THF was added to the reactor as a compound of formula II. Medium, stirring and cooling to -78 CAfter that, the THF solution of the compound of the formula II is added dropwise to the reactor, and the reaction system is heated to -50 C, and the mixture is kept under stirring for 1 hour;(2) Ethyl glyoxylate was dissolved in 7 mL of toluene, added to the reactor, stirred under heat for 2 h, and the reaction system was cooled to room temperature;(3) 10 mL of ethyl acetate and 1N hydrochloric acid solution were separately added to the reactor, and after extraction, the organic layer was separated, and the organic layer was washed with brine, dried over anhydrous sodium sulfate, and the solvent was evaporated to dryness and concentrated. After separation by column chromatography, ethyl 2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetate of the formula I was obtained in a yield of 85%.
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