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Chemical Structure| 1155278-31-1 Chemical Structure| 1155278-31-1
Chemical Structure| 1155278-31-1

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CAS No. :1155278-31-1
Formula : C11H22N2O3
M.W : 230.30
SMILES Code : CC(C)(C)C(NC(NC(C)(C)C)=O)C(O)=O
MDL No. :N/A

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1155278-31-1 ]

[ 1155278-31-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33105-81-6 ]
  • [ 1609-86-5 ]
  • [ 1155278-31-1 ]
YieldReaction ConditionsOperation in experiment
99% The pH of a stirred aqueous solution (1150 g) containing L-<strong>[33105-81-6]tert-leucine</strong> (100 g, 762 mmol) was adjusted to 11.5 using a 48percent by weight aqueous sodium hydroxide solution. Thereafter, tert-butyl isocyanate (75.5 g, 762 mmol) was slowly added thereto in an ice bath. The reaction was completed in 6 hours after the addition. The reaction mixture was analyzed with HPLC; as a result, it was found that 172 g of an N-tert-butylcarbamoyl-L-<strong>[33105-81-6]tert-leucine</strong> was generated (yield: 98percent), and 0.02percent of a dipeptide-like compound and 0.07percent of N,N'-di(tert-butyl)urea were generated. The amount of the enantiomer was below measurable limits, i.e., 0.01percent. The pH of the reaction mixture after the reaction was 9.3.
 

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