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Chemical Structure| 1161829-68-0 Chemical Structure| 1161829-68-0

Structure of 1161829-68-0

Chemical Structure| 1161829-68-0

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Product Details of [ 1161829-68-0 ]

CAS No. :1161829-68-0
Formula : C14H17F3N2O2
M.W : 302.29
SMILES Code : O=C(N1CC(C2=NC=CC(C(F)(F)F)=C2)C1)OC(C)(C)C
MDL No. :MFCD20528739

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Application In Synthesis of [ 1161829-68-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1161829-68-0 ]

[ 1161829-68-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 206446-38-0 ]
  • [ 175205-81-9 ]
  • [ 1161829-68-0 ]
YieldReaction ConditionsOperation in experiment
37% With iodobenzene;tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; In tetrahydrofuran; at 20 - 65℃; for 2.16667h; In a separate flask, Pd2(dba)3 (45 mg, 0.05 mmol), P(2-furyl)3 (46 mg, 0.2 mmol) and <strong>[175205-81-9]2-bromo-4-(trifluoromethyl)pyridine</strong> (1.36 mg, 6 mmol) were mixed in THF (1 mL) under N2 for 10 min. This mixture was added to the organozinc reagent solution mentioned above, followed by iodobenzene (1.36 g, 6 mmol) in THF (10 mL). The mixture was heated at 65 °C for 2 h, then cooled, diluted with ethyl acetate and filtered over celite. The filtrate was washed with NaHCO3 (x2), brine (xl) and concentrated. The crude was purified by column chromatography to give the desired product tert-butyl 3-(4-(trifluoromethyl)pyridin-2- yl)azetidine-l-carboxylate (554 mg, 37percent yield): 1H NMR (400 MHz, CDCl3): delta 8.15(d, IH), 7.42 (s, IH), 7.42(d, IH), 4.34 (t, 2H), 4.19 (dd, 2H), 3.95 (dq, IH) 1.47 (s, 9H); MS (ESI) m/z: Calculated for C14HnF3N2O2: 302.29; found: 247.0 (M-1Bu)+.
 

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