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Chemical Structure| 1169755-45-6 Chemical Structure| 1169755-45-6

Structure of INDY
CAS No.: 1169755-45-6

Chemical Structure| 1169755-45-6

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INDY is inhibitor of DYRK1B and DYRK1A with IC50 values of 0.23 and 0.24 μM respectively.

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Product Details of INDY

CAS No. :1169755-45-6
Formula : C12H13NO2S
M.W : 235.30
SMILES Code : CCN(/C1=C([H])/C(C)=O)C2=C(S1)C=CC(O)=C2
MDL No. :MFCD28100814

Safety of INDY

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H401
Precautionary Statements:P264-P270-P273-P301+P312-P330-P501

Related Pathways of INDY

RTK

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HEK293 cells 0–5000 μM Measure mINDY transport capacity for citrate and succinate Hepatology. 2017 Aug;66(2):616-630

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice Western diet-induced non-alcoholic fatty liver disease model Tail vein injection 1 mg/kg Once weekly for 8 weeks To evaluate the effect of siINDY on hepatic insulin sensitivity and fatty liver. Results showed that siINDY improved hepatic insulin sensitivity and prevented diet-induced fatty liver. Mol Metab. 2016 Aug 13;5(11):1072-1082

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