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Chemical Structure| 1171197-20-8 Chemical Structure| 1171197-20-8

Structure of 1171197-20-8

Chemical Structure| 1171197-20-8

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Product Details of [ 1171197-20-8 ]

CAS No. :1171197-20-8
Formula : C16H24N2O2
M.W : 276.37
SMILES Code : O=C(N1C[C@H](C2=CC=C(N)C=C2)CCC1)OC(C)(C)C
MDL No. :MFCD27921195

Safety of [ 1171197-20-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1171197-20-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1171197-20-8 ]

[ 1171197-20-8 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 19733-56-3 ]
  • [ 1171197-20-8 ]
  • [ 1263284-59-8 ]
  • 3
  • [ 87-69-4 ]
  • [ 24424-99-5 ]
  • [ 19733-56-3 ]
  • [ 1171197-20-8 ]
YieldReaction ConditionsOperation in experiment
12.1 g 110 mL of acetonitrile was added to Compound 7 (25 g, 0.13 mol), heated to reflux,L-tartaric acid (15.2 g, 0.104 mol) was added portionwise and after refluxing for 2 hours after addition,Slowly reduced to 10 C (within 1.5 hours) and stirred at this temperature overnight. After filtering off the solids,The solid was added with ethanol 85mL, heated to reflux and stirred for 1 hour,After cooling to room temperature crystallization 8 hours, filtered off the solid,And dried under reduced pressure (45 C) to give 16.4g as an off-white solid,The obtained solid was added with 50 mL of ethyl acetate, and 30 mL of 0.1 M sodium hydroxide solution was added thereto,After stirring for 20 minutes, the mixture was extracted twice with ethyl acetate (2 * 50 mL)The organic phase was washed once with saturated citric acid (100 mL), the organic phase was dried over anhydrous sodium sulfate,The organic phase was evaporated under pressure to give a pale yellow oil 8.7g, dichloromethane was added 60mL,Di-tert-butyl dicarbonate(10.8 g, 0.05 mol). Triethylamine (5.70 g, 0.057 mol) and DMAP (0.460 g, 3.80 mmol) were added and the mixture was reacted at room temperature for 8 hours. The reaction mixture was washed with saturated bicarbonate , Dried over anhydrous sodium sulphate and the organic phase was autoclaved to give 12.1 g of light yellow solid.
 

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