1174429-23-2|3-bromo-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one| Ambeed

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Yield	Reaction Conditions	Operation in experiment
18%	With tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; at 80℃; for 18h;	3-Bromo-5-morpholino-4-oxa-1thia-7indenone (Compound 126) (48 mg, 0.15 mmol), <strong>[376584-63-3]1H-pyrazole-5-boronic acid</strong> (21 mg, 0.18 mmol), Pd[PPh3]4 (20 mg., 0.015 mmol) were taken into a mixture of toluene (0.8 mL), H2O/EtOH 1:1 (0.9 mL) under stirring and heated to 80° C. for 18 hours. Then the reaction mixture was cooled and diluted with ethyl acetate (30 mL) and filtered. The filtrate was washed with water, dried (Na2SO4), filtered and concentrated to yield a eluting solid product (40 mg). The crude was perused by preparative TLC plate on silica gel, eluting with 30:70 v/v ethyl acetate: CH2Cl2 yielding (8 mg, 0.026 mmol. 18percent) of the final compound 129. HPLC (254 nm)-Rt 0.65 min. MS (ESI) mo/z 304.1 [M+H]+Purity=>95percent by UV (254 nm).

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Precautionary Statements-General
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Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
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H221	Flammable gas
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H240	Heating may cause an explosion
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H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
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H319	Causes serious eye irritation
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H361d	Suspected of damaging the unborn child
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H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

CAS No. :	1174429-23-2	MDL No. :	MFCD26744038
Formula :	C₁₁H₁₀BrNO₃S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	316.18	Pubchem ID :	-
Synonyms :

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

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[ 1174429-23-2 ] Synthesis Path-Downstream 1~3

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