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[ CAS No. 117519-07-0 ]

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Chemical Structure| 117519-07-0
Chemical Structure| 117519-07-0
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CAS No. :117519-07-0 MDL No. :MFCD10696218
Formula : C6H3F3N2O3 Boiling Point : 278.6±40.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :208.09 g/mol Pubchem ID :-
Synonyms :

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Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 117519-07-0 ]

  • Upstream synthesis route of [ 117519-07-0 ]
  • Downstream synthetic route of [ 117519-07-0 ]

[ 117519-07-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 10026-13-8 ]
  • [ 117519-07-0 ]
  • [ 117519-08-1 ]
YieldReaction ConditionsOperation in experiment
5 g at 170℃; for 2.5 h; C)
2-chloro-3-nitro-6-(trifluoromethyl)pyridine
To 3-nitro-6-(trifluoromethyl)pyridin-2-ol (5.5 g) was added phosphorous pentachloride (25.0 g) at room temperature.
The reaction mixture was stirred at 170°C for 2.5 hr, cooled to room temperature, and slowly poured into ice-water.
The mixture was extracted with ethyl acetate, and the extract was washed successively with saturated brine and saturated aqueous sodium hydrogen carbonate solution, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (5.0 g).
1H NMR (300 MHz, CDCl3) δ 7.84 (1H, d, J = 8.1 Hz), 8.38 (1H, d, J = 8.1 Hz).
Reference: [1] Patent: EP2848618, 2015, A1, . Location in patent: Paragraph 0652
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