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Chemical Structure| 1178550-13-4 Chemical Structure| 1178550-13-4

Structure of 1178550-13-4

Chemical Structure| 1178550-13-4

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Product Details of [ 1178550-13-4 ]

CAS No. :1178550-13-4
Formula : C14H12F2
M.W : 218.24
SMILES Code : FC1=C(F)C(C2=CC=C(CC)C=C2)=CC=C1

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Application In Synthesis of [ 1178550-13-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1178550-13-4 ]

[ 1178550-13-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38573-88-5 ]
  • [ 63139-21-9 ]
  • [ 1178550-13-4 ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; N,N-dimethyl-formamide; at 80℃; for 8h; To a 500 mL three-necked flask equipped with a thermometer, a condenser and a magnetic stirrer were added 33.0 (0.21 mol) of 4-ethylbenzeneboronic acid, 38.6 g (0.20 mol) of <strong>[38573-88-5]2,3-difluorobromobenzene</strong>, 58.0 g (0.42 mol) of potassium carbonate, 240 mL of N, N- dimethylformamide and 80 mL of H2O. The temperature was raised to 80°C. After the solid was totally dissolved, 2.3g (2mmol) of tetrakis(triphenylphosphine)palladium was added and the reaction was carried out at 80 ° C for 8 hours. The reaction mixture was diluted with petroleum ether and the organic phase was separated. The aqueous layer was extracted three times with petroleum ether The organic phase was combined and washed with water until neutral, dried over anhydrous magnesium sulfate, filtered and the solvent was distilled off under reduced pressure. A fraction of 110-115C / 40Pa was collected to obtain a colorless oil.
 

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