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CAS No. : | 1184172-46-0 | MDL No. : | MFCD13189885 |
Formula : | C5H3ClFNO | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | KMUSIJQLKVODNC-UHFFFAOYSA-N |
M.W : | 147.54 | Pubchem ID : | 70700710 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With potassium carbonate; In acetone;Reflux; | 2-Chloro-3-fluoro-4-hydroxypyridine (10 mmol), methyl iodide (20 mmol) and potassium carbonate (20 mmol) in acetone (100 ml) was refluxed overnight. The inorganic salt was filtered and the solvent was evaporated. The residue was purified on column (eluent: ethyl acetate: hexane = 1 :5) to afford a colorless liquid (52%). |
52% | With potassium carbonate; In acetone;Reflux; | 2-Chloro-3-fluoro-4-methoxypyridine (11): 2-Chloro-3-fluoro-4-hydroxypyridine (10 mmol), methyl iodide (20 mmol) and potassiumcarbonate (20 mmol) in acetone (100 ml) was refluxedovernight. The inorganic salt was filtered and the solvent wasevaporated. The residue was purified on column (eluent: ethylacetate:hexane = 1:5) to afford a colorless liquid [19] (52%). 1HNMR (CDCl3): d 8.08 (dd, J = 1.0, 5.8 Hz, 1H, C6-H), 6.88 (t,J = 5.7 Hz, 1H, C5-H), 3.97 (s, 3H, OMe). 19F NMR (CDCl3): d 143.49(s). ESI-MS: 162 (M+1)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With potassium carbonate; In acetone;Reflux; | 2-Chloro-3-fluoro-4-hydroxypyridine (10 mmol), which previously described in the scheme 11, methyl iodide (20 mmol) and potassium carbonate (20 mmol) in acetone (100 ml) was refluxed overnight. The inorganic salt was filtered and the solvent was evaporated. The residue was purified on column eluting with ethyl acetate to afford a white solid (58%). |