[ CAS No. 119018-29-0 ]

Name: 119018-29-0|4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide|98%
Brand: Ambeed
SKU: A296669
Price: 6.0 USD
Availability: InStock
Rating: 99 (35 reviews)

{[proInfo.proName]} ,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

2D 3D

Structure of 119018-29-0 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Bulk Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 100K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 119018-29-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 119018-29-0 ]

SDS Specification

Alternatived Products of [ 119018-29-0 ]

Product Details of [ 119018-29-0 ]

CAS No. :	119018-29-0	MDL No. :	MFCD02955393
Formula :	C₁₆H₂₁N₃O₄S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	AJEMFZRCUKJSES-UHFFFAOYSA-N
M.W :	351.42 g/mol	Pubchem ID :	11772520
Synonyms :

Calculated chemistry of [ 119018-29-0 ]

Physicochemical Properties

Num. heavy atoms :	24
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.38
Num. rotatable bonds :	7
Num. H-bond acceptors :	5.0
Num. H-bond donors :	2.0
Molar Refractivity :	93.48
TPSA :	117.95 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.57 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.24
Log Po/w (XLOGP3) :	1.23
Log Po/w (WLOGP) :	1.85
Log Po/w (MLOGP) :	0.49
Log Po/w (SILICOS-IT) :	0.87
Consensus Log Po/w :	1.14

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.52
Solubility :	1.07 mg/ml ; 0.00304 mol/l
Class :	Soluble
Log S (Ali) :	-3.3
Solubility :	0.174 mg/ml ; 0.000496 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.22
Solubility :	0.0213 mg/ml ; 0.0000607 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.92

Safety of [ 119018-29-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 119018-29-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 119018-29-0 ]
Downstream synthetic route of [ 119018-29-0 ]

[ 119018-29-0 ] Synthesis Path-Upstream 1~10

1
[ 32175-00-1 ]
[ 119018-29-0 ]
[ 93479-97-1 ]

Reference： [1] Patent: CN108383768, 2018, A, . Location in patent: Paragraph 0103-0106

2
[ 119043-16-2 ]
[ 119018-29-0 ]

Yield	Reaction Conditions	Operation in experiment
8.47 kg	With ammonium hydroxide In methanol at 20 - 30℃; for 2 h; Industrial scale	38.0 kg of methanol was sequentially added to a 100 L reactor.Industrial ammonia water 5.1Kg; start stirring,Add the above intermediate 2 crude wet product at 20-30 ° C,And the reaction was kept for 2 hours; the sample was controlled by HPLC, and the reaction was completely filtered and washed with water.The obtained white intermediate 3 crude wet product was directly charged into another 200 L reaction kettle.Further, 110.0 kg of methanol was added, and the temperature was raised to 65-75 ° C, and the mixture was stirred for 4 hours.Cool down to 20-25 ° C, filter,Drying white solid intermediate 3 refined product 8.47kg, HPLC purity >99percent,The meta isomer impurity was 0.2

Reference： [1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855
[2] Patent: WO2006/103690, 2006, A1, . Location in patent: Page/Page column 7,14-15
[3] Patent: CN108383768, 2018, A, . Location in patent: Paragraph 0101; 0102

3
[ 35303-76-5 ]
[ 119018-29-0 ]

Yield	Reaction Conditions	Operation in experiment
85%	at 20℃;	3-Ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate(1; 1.349 g, 5.5 mmol) and 4-(2-aminoethyl)benzenesulfonamide(1.001 g, 5 mmol) were dissolved in THF (40 mL), and themixture was stirred at r.t. over night. After completion of thereaction (TLC), the solvent was evaporated under reduced pressure,and the crude product was purified by crystallization(EtOAc) to give a white solid yield: 1.495 g, (85percent); mp 183–185 °C.1H NMR (400 MHz, DMSO-d6): δ = 8.37 (t, J = 5.2 Hz, 1 H), 7.45(d, J = 7.8 Hz, 2 H), 7.43 (d, J = 7.8 Hz, 2 H), 7.32 (s, 2 H), 4.17 (s, 2H), 3.49 (q, J = 6.0 Hz, 2 H), 2.88 (t, J = 6.5 Hz, 2 H), 2.18 (q, J = 7.3Hz, 2 H), 2.01 (s, 3 H), 0.97 (t, J = 7.4 Hz, 3 H). 13C NMR (100MHz, DMSO-d6): δ = 172.3, 152.5, 152.1, 143.8, 142.6, 132.3,129.5, 126.2, 52.3, 40.6, 35.5, 16.4, 13.3, 13.2. HRMS (ESI): m/z[M + Na]+ calcd for C16H21N3NaO4S: 374.1150; found: 374.1140.

Reference： [1] Synlett, 2017, vol. 28, # 18, p. 2495 - 2498

4
[ 247098-17-5 ]
[ 119018-29-0 ]

Reference： [1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855

5
[ 607-97-6 ]
[ 119018-29-0 ]

Reference： [1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855

6
[ 766-36-9 ]
[ 119018-29-0 ]

Reference： [1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855
[2] Synlett, 2017, vol. 28, # 18, p. 2495 - 2498
[3] Patent: CN108383768, 2018, A,

7
[ 247098-18-6 ]
[ 119018-29-0 ]

Reference： [1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855
[2] Patent: CN107935903, 2018, A,
[3] Patent: CN108383768, 2018, A,

8
[ 61892-80-6 ]
[ 119018-29-0 ]

Reference： [1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855

9
[ 622-24-2 ]
[ 119018-29-0 ]

Reference： [1] Patent: CN107963988, 2018, A,
[2] Patent: CN107935903, 2018, A,

10
[ 1943-82-4 ]
[ 119018-29-0 ]

Reference： [1] Patent: CN108383768, 2018, A,

[ 119018-29-0 ] Synthesis Path-Downstream 1~22

1
[ 599174-27-3 ]
[ 119018-29-0 ]
[ 599174-28-4 ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855

2
[ 119043-16-2 ]
[ 119018-29-0 ]

Yield	Reaction Conditions	Operation in experiment
97.8%	With ammonia; In water; at 80℃; for 1.5h;	120 g of chlorosulfonic acid was added to a three-necked bottle, and the compound m was added in portions. After the addition, the reaction was kept at 80 C for 0.5 hour. The reaction was completely monitored by TLC, and the temperature was lowered to 25 C. The reaction was dropped into ice water and filtered to obtain a solid. Adding solid to a solution of 200 ml of ammonia water and 100 ml of water, heating to 80 C for 1.5 hours, cooling to 30 C, adding hydrochloric acid to the reaction solution, separating the solid, filtering, washing with water, drying at 50 C, The obtained white solid was 25.2 g, and the purity by HPLC was 78.08%, the impurity V 7.24%, the impurity was 16.35%, and the yield was 97.8%.
	With ammonia; at 70℃; for 3 - 4h;	Example 2Preparation of 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl ] benzene sulfonamide (IV)3-Ethyl-4-methyl-2,5-dihydro-lH- pyrrole-2-one (II) (1.0 Kg) and beta-phenylethyl isocyanate (1.488 Kg) were mixed in anhydrous toluene (4.0 L) and refluxed for 4 hrs. The toluene was distilled off and hexane (8.0 L) was added to the reaction mixture at 5O0C. The product precipitated is cooled to 0 to 5 C to obtain the solid compound viz. 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene (2.17 Kg). It was filtered & washed with 2.0 L of hexane.To a cooled (15 to 25 C) solution of chlorosulfonic acid (2.8 L), 4-[2-(3-Ethyl-4- methyl-2-carbonyl pyrrolidine amido) ethyl] benzene (2.0 Kg) was added in small portions over a period of 2 to 3 hrs. Further it was stirred for 30 min at this temperature and then temperature was gradually raised to 30 to 350C. The reaction mass is stirred further for 2 hrs. The reaction mixture was then quenched into ice- water and stirred for 1 hr and filtered to obtain the product 4-[2-(3-Ethyl-4-methyl-2- carbonyl pyrrolidine amido) ethyl] benzene sulfonyl chloride (2.0 kg). To a cooled (15 to 200C) solution of diluted ammonia (1.4 L) 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonyl chloride was added in small portion over 1 to 2 hrs. The reaction mixture was then heated to 7O0C for 2 hrs when ammonolysis is complete. The product converted is then stirred for 1 hr at R.T. and filtered and dried at 90. to 100 C to obtain crude 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide (2.2 Kg) having HPLC purity in the range of 82 to 88%. The crude compound 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide (2.2 Kg) is then purified from mixture of organic solvents chosen from Methanol, Acetone & toluene.
8.47 kg	With ammonium hydroxide; In methanol; at 20 - 30℃; for 2h;Industrial scale;	38.0 kg of methanol was sequentially added to a 100 L reactor.Industrial ammonia water 5.1Kg; start stirring,Add the above intermediate 2 crude wet product at 20-30 C,And the reaction was kept for 2 hours; the sample was controlled by HPLC, and the reaction was completely filtered and washed with water.The obtained white intermediate 3 crude wet product was directly charged into another 200 L reaction kettle.Further, 110.0 kg of methanol was added, and the temperature was raised to 65-75 C, and the mixture was stirred for 4 hours.Cool down to 20-25 C, filter,Drying white solid intermediate 3 refined product 8.47kg, HPLC purity >99%,The meta isomer impurity was 0.2 <%, and the molar yield was 64% (based on the intermediate 1).

Reference： [1]Patent: CN110092739,2019,A .Location in patent: Paragraph 0022
[2]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855
[3]Patent: WO2006/103690,2006,A1 .Location in patent: Page/Page column 7,14-15
[4]Patent: CN108383768,2018,A .Location in patent: Paragraph 0101; 0102

3
[ 766-36-9 ]
[ 119018-29-0 ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855
[2]Synlett,2017,vol. 28,p. 2495 - 2498
[3]Patent: CN108383768,2018,A

4
[ 61892-80-6 ]
[ 119018-29-0 ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855

5
[ 247098-17-5 ]
[ 119018-29-0 ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855

6
[ 607-97-6 ]
[ 119018-29-0 ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855

7
[ 247098-18-6 ]
[ 119018-29-0 ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855
[2]Patent: CN107935903,2018,A
[3]Patent: CN108383768,2018,A

8
[ 119018-29-0 ]
trans-hydroxyglimepiride [ No CAS ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855

9
[ 119018-29-0 ]
cis-hydroxyglimepiride [ No CAS ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 4853 - 4855

10
[ 541-41-3 ]
[ 119018-29-0 ]
C₁₉H₂₅N₃O₆S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With triethylamine; In dichloromethane; at 5 - 30℃;	Examples: Example 1: Preparation of carbamate of Formula IX (R'= ethyl, and Grp1=D) In a reaction vessel 100 gm of 4[2-(3-ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide, 72 gm triethyl amine and 1.6 lit dichloromethane were taken and the mixture cooled to 0 C. 46.15 gm of ethyl chloroformate was diluted separately with 200 ml dichloromethane and added into the reaction vessel drop wise while maintaining the temperature at around 5 C and maintained for 2 hours at 5 C and then at 25 to 30 C till completion of reaction. 2 L water and 0.7 L dichloromethane was added and the pH of the reaction mass were adjusted to 4 by addition of acetic acid. The organic layer was separated and washed with water and concentrated to dryness. The residue was refluxed with 300 ml acetone and cooled to 25 to 30 C, maintained for 1 hour, filtered and washed with 100 ml chilled acetone to get 100 gm carbamate of Formula IX (yield 83percent, purity 99.7percent). Melting Point: 177 to 182 C
83%	With triethylamine; In dichloromethane; at 0 - 30℃; for 2h;	In a reaction vessel 100 g of 4[2-(3-ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide, 72 g triethyl amine, and 1.6 L of dichloromethane were mixed and cooled to 0° C. 46.15 g of ethyl chloroformate was diluted separately with 200 mL of dichloromethane and added into the reaction vessel drop wise while maintaining the temperature at around 5° C. for 2 hours, and then at 25 to 30° C. until completion of the reaction. 2 L of water and 0.7 L of dichloromethane were added; and the pH of the reaction mass was adjusted to 4 by addition of acetic acid. The organic layer was then separated, washed with water, and concentrated to dryness. The residue was refluxed with 300 mL of acetone and cooled to 25 to 30° C., maintained for 1 hour, filtered, and washed with 100 mL of chilled acetone to obtain 100 g carbamate of Formula IX (yield 83percent, purity 99.7percent, and melting point: 177 to 182° C.).

Reference： [1]Patent: EP1700848,2006,A1 .Location in patent: Page/Page column 8
[2]Patent: US2007/255056,2007,A1 .Location in patent: Page/Page column 5-6

11
trans-4-methyl cyclohexyl isocyanate [ No CAS ]
[ 119018-29-0 ]
[ 93479-97-1 ]

Yield	Reaction Conditions	Operation in experiment
~ 50%		4- [2- (3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide(100g) was dissolved in tetrahydrofuran (1800 ml) by stirring and gradually heating to reflux. The reaction mixture was cooled to50-55 C and dryK2CO3 (61 g) was added to it and heated gradually to reflux and maintained for 6 hours. Approximately 300 ml of solvent was distilled of from the reaction mixture during this time.Trans-4-methylyclohexyl isocyanate(221g) in toluene (24.46percent w/w) was added to the reaction mixture at reflux temperature in 5-10 minutes. The reaction mixture was refluxed for 6 hours and then cooled to40-45 C and filtered at this temperature. The product was washed with tetrahydrofuran (300 ml) and suck dried for 30 minutes. Then it was taken into DM water(2000ml) and stirred for 15 min at25-30 C, the pH was adjusted to 6-6.5 withHC1 solution (130 ml, 1: 1) and stirred for 30 minutes at20-25 C. Then pH was brought to 8- 8.5 by drop wise addition of 5percent aq KOH solution (about 20 ml) and stirred for 30 minutes at25-30 C. The product was filtered and washed with water (400 ml), followed by methanol (20 ml), suck dried and slurried in water (2000 ml) for 1 hour at45-50 C and filtered. The wet cake was slurried in toluene (1000 ml) for 1 hour at 80-85 C, cooled and filtered, washed with toluene, followed by methanol to obtain glimepiride, wet weight: 200g (moisturecontent-50percent).

Reference： [1]Patent: WO2005/49532,2005,A2 .Location in patent: Page/Page column 10

12
[ 32175-00-1 ]
[ 119018-29-0 ]
[ 93479-97-1 ]

Yield	Reaction Conditions	Operation in experiment
94.5%	In tert-butyl methyl ether; cyclohexanone; at 30℃; for 10h;	2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethylbenzenesulfonamide (F) prepared in Example 5 (2.6 g, 1.37 mol )After being mixed with trans-p-methylcyclohexyl isocyanate (G) (2.1 g, 1.64 mol), it was dissolved in a mixture of cyclohexanone (45 ml) and methyl tert-butyl ether (30 ml), and heated to 30°C in a water bath. ,After stirring for 10 hours, the heating was stopped, and the mixture was naturally stirred and cooled to 10° C., poured into water, extracted with dichloromethane (90 ml), concentrated, dissolved in ethanol, and crystallized at 3° C.Dry to give 1-[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfonyl]-3 -(trans-4-methylcyclohexyl)-urea (H) (3.74 g), yield 94.5percent, purity 99.82percent.
86.3%		Example 4Preparation of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans;-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo- 1 H-pyrrole- 1 - carboxamide (I).In a reaction vessel containing (24.2 L) Acetone, 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide (1.0 Kg) and potassium carbonate (0.46 Kg) was added and refluxed at about 55 to 60 C for 1 hr. trans-4-Methyl- cyclohexyl isocyanate was obtained by method known in art from trans-4-methyl- cyclohexylamine. A solution of trans-4-methyl-cyclohexyl isocyanate (0.515 Kg) in toluene (5 L) was prepared and added to the above reaction mixture. This reaction mixture is refluxed for 12 lirs, then cooled. To this cooled reaction mass charge 27 L of water. The reaction mass was filtered and the pH was adjusted to 5.5 to 6.0 by adding acetic acid at about 20 to 250C. The solid obtained was filtered and washed with water. The 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(/7-?ro-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-lH-pyrrole-l- carboxamide (I) obtained is then dried at 90 to 1000C till constant weight. Yield of the product is 86.3percent. Example 5Purification of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(tr?ro-4-methyl cyclohexyl)amino] carbonyl] amino] sulfonyljphenyl] ethyl] -2-oxo- 1 H-pyrrole- 1 - carboxamide (I)In a reaction vessel containing 6.0 L methanol and 1.0 Kg crude Glimepiride, dry ammonia gas was purged at 20 to 25 C till all Glimepiride dissolves and a clear solution is obtained. This homogeneous mass was then charcoalised, filtered and finally neutralized with Glacial acetic acid to pH 5.5 to 6.0, till the entire product precipitates out. The pure Glimepiride was then filtered and dried at 65C to 700C till constant weight. Yield obtained was ~ 90percent.

Reference： [1]Patent: CN107935903,2018,A .Location in patent: Paragraph 0020; 0021
[2]Patent: WO2006/103690,2006,A1 .Location in patent: Page/Page column 7,16

13
[ 210827-31-9 ]
[ 119018-29-0 ]
3-ethyl-N-(4-(N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)sulfamoyl)phenethyl)-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide [ No CAS ]

Reference： [1]ChemMedChem,2017,vol. 12,p. 1449 - 1457

14
phenyl 3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate [ No CAS ]
[ 35303-76-5 ]
[ 119018-29-0 ]

Yield	Reaction Conditions	Operation in experiment
85%	In tetrahydrofuran; at 20℃;	3-Ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate(1; 1.349 g, 5.5 mmol) and 4-(2-aminoethyl)benzenesulfonamide(1.001 g, 5 mmol) were dissolved in THF (40 mL), and themixture was stirred at r.t. over night. After completion of thereaction (TLC), the solvent was evaporated under reduced pressure,and the crude product was purified by crystallization(EtOAc) to give a white solid yield: 1.495 g, (85%); mp 183-185 C.1H NMR (400 MHz, DMSO-d6): delta = 8.37 (t, J = 5.2 Hz, 1 H), 7.45(d, J = 7.8 Hz, 2 H), 7.43 (d, J = 7.8 Hz, 2 H), 7.32 (s, 2 H), 4.17 (s, 2H), 3.49 (q, J = 6.0 Hz, 2 H), 2.88 (t, J = 6.5 Hz, 2 H), 2.18 (q, J = 7.3Hz, 2 H), 2.01 (s, 3 H), 0.97 (t, J = 7.4 Hz, 3 H). 13C NMR (100MHz, DMSO-d6): delta = 172.3, 152.5, 152.1, 143.8, 142.6, 132.3,129.5, 126.2, 52.3, 40.6, 35.5, 16.4, 13.3, 13.2. HRMS (ESI): m/z[M + Na]+ calcd for C16H21N3NaO4S: 374.1150; found: 374.1140.
85.5%	In isopropyl alcohol; for 6h;Reflux;	The compound Kappa 5.0g, 4-(2-aminoethyl)benzenesulfonamide 4.08g and isopropanol 50g were heated under reflux for 6 h (4-(2-aminoethyl)benzenesulfonamide remaining 0.79%), cooled to After drying at 25 C, filtration and 50 C, 6.12 g of compound I was obtained. The purity of the solution was 98.66% by HPLC, the impurity was 0.60%, and the impurities V and VI were not detected. The yield was 85.5%.

Reference： [1]Synlett,2017,vol. 28,p. 2495 - 2498
[2]Patent: CN110092739,2019,A .Location in patent: Paragraph 0023; 0024; 0025; 0028

15
phenyl ((1r,4r)-4-methylcyclohexyl)carbamate [ No CAS ]
[ 119018-29-0 ]
[ 93479-97-1 ]

Yield	Reaction Conditions	Operation in experiment
85%	With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 5h;Reflux;	Carboxamide 2 (1.054 g, 3 mmol) and carbamate 3 (0.770 g, 3.3mmol) were dissolved in MeCN (40 mL), and DBU (0.685 g, 4 5mmole) was added. The mixture was then refluxed for 5 h until the reaction was complete (TLC). The solvent was evaporatedunder reduced pressure, the residue was dissolved in EtOAc(100 mL), and the solution was extracted with 0.1 N aq HCl (2 ×50 mL). The organic layer was washed with brine (2 × 50 mL),dried (Na2SO4), filtered, and concentrated again under reducedpressure. The crude product was purified by crystallization(MeOH) to give a white solid; yield: 1.255 g (85percent); mp 202?204 °C.1H NMR (400 MHz, DMSO-d6): delta = 8.38 (t, J = 5.6 Hz, 1 H), 7.81(d, J = 8.2 Hz, 2 H), 7.46 (d, J = 8.2 Hz, 2 H), 6.28 (d, J = 7.6 Hz, 1H), 4.16 (s, 2 H), 3.50 (q, J = 6.4 Hz, 2 H), 3.21?3.15 (m, 1 H), 2.90(t, J = 7.1 Hz, 2 H), 2.18 (q, J = 7.5 Hz, 2 H), 2.01 (s, 3 H), 1.68 (d,J = 12.8 Hz, 2 H), 1.59 (d, J = 12.8 Hz, 2 H), 1.23?0.79 (m, 11 H).13C NMR (100 MHz, DMSO-d6): delta = 171.7, 151.9, 151.5, 150.4,144.8, 138.1, 131.8, 129.0, 127.2, 51.8, 48.4, 39.9, 35.1, 33.2,32.2, 31.1, 21.9, 15.9, 12.7, 12.6. HRMS (ESI): m/z [M + Na]+ calcdfor C24H34N4NaO5S:, 513.2148; found: 513.2133.

Reference： [1]Synlett,2017,vol. 28,p. 2495 - 2498

16
trans-4-methylcyclohexylamine [ No CAS ]
[ 530-62-1 ]
[ 119018-29-0 ]
glimepiride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85.1%		Under nitrogen protection,In the reactor,N-4- [2- (3-ethyl-4-methyl-2-oxo-3-pyrroline- 1 -carboxamido) ethyl] -benzenesulfonamide (33.6 g, 0.1 mol)Hexamethylphosphoric triamide (200 mL),1,8-diazabicyclo [5,4,0] undecene-7 (15.2 g, 0.1 mol),Then N, N'-carbonyldiimidazole (32.4 g, 0.2 mol),After heating to 80 ° C for 3 hours, hexamethylphosphoric triamide (20 mL) of trans 4-methylcyclohexylamine (11.3 g, 0.1 mol)The reaction was heated overnight,TLC detection and tracking reaction,After the disappearance of raw materials completely,Stop stirring,cool down,Suction filtration,Washed,Dry glimepiride 41.6gWhite solid.Melting at 207-208 ° C,The yield was 85.1percent

Reference： [1]Patent: CN107400077,2017,A .Location in patent: Paragraph 0018; 0020; 0021; 0022

17
3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamide [ No CAS ]
[ 119018-29-0 ]

Reference： [1]Patent: CN107963988,2018,A
[2]Patent: CN107935903,2018,A

18
[ 622-24-2 ]
[ 119018-29-0 ]

Reference： [1]Patent: CN107963988,2018,A
[2]Patent: CN107935903,2018,A

19
4-{2-[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carbonyl)amino]ethyl}benzene-1-sulfonic acid [ No CAS ]
[ 119018-29-0 ]

Yield	Reaction Conditions	Operation in experiment
90.28%	With ammonia; In 1,4-dioxane; at 35℃;	2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethylbenzenesulfonic acid prepared in Example 3 (E)(3.8 g, 1.64 mol) was dissolved in a flask containing dioxane (40 ml) and ammonia gas was introduced at 35°C.After the reaction was completed, dilute with dichloromethane (60 ml).The organic phase was concentrated, washed with water, recrystallized from ethanol, and dried to give 3-ethyl-4-methyl-2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2,5-dihydro-1H-pyrrole-1-carboxamide (F ) (3.11g),The yield was 90.28percent and the purity was 99.69percent.
90.28%	With ammonia; In 1,4-dioxane; at 35℃;	2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethylbenzenesulfonic acid (E) prepared in Example 3 (3.8 g, 1.64 mol )Dissolve in a flask containing dioxane (40ml) and introduce ammonia gas at 35°C.2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethylbenzenesulfonamide (F) (3.11 g) was prepared,The yield was 90.28percent and the purity was 99.69percent.

Reference： [1]Patent: CN107963988,2018,A .Location in patent: Paragraph 0005; 0017-0018
[2]Patent: CN107935903,2018,A .Location in patent: Paragraph 0018; 0019

20
[ 32175-00-1 ]
[ 119018-29-0 ]
[ 93479-97-1 ]

Yield	Reaction Conditions	Operation in experiment
		Add 67 kg of acetonitrile to the 200 L reactor.Intermediate 3 refined product 8.47kg, potassium carbonate 4.00kg,Turn on the agitation and warm to 50-60 ° C.6.01 kg of trans-4-methylcyclohexyl isocyanate was added, and the reaction was continued for 6 hours.Sampling HPLC control, the reaction is complete, filtered, washed,The obtained glimepiride metal salt crude wet product is put into the next step to remove the insoluble matter. Step 5: remove insolubles, acidify, and refine Adding the above-mentioned glimepiride metal salt crude wet product and 10 times by weight of purified water to a 500 L reaction kettle,Stir at 70-75 ° C for 4 hours, heat filter, filter residue to waste treatment station,The filtrate enters the clean room 500L reactor and is cooled to 20-25 °C.Add 15percent hydrochloric acid to adjust pH=1-2, filter, wash,The obtained glimepiride crude wet product is reflowed by refluxing with 5 times by weight of acetone of glimepiride crude wet product.It is then cooled to room temperature, filtered and dried to obtain a finished glimepiride.HPLC purity >99.5percent,The molar yield was 80percent (based on the intermediate 3 refined product).

Reference： [1]Patent: CN108383768,2018,A .Location in patent: Paragraph 0103-0106

21
[ 1943-82-4 ]
[ 119018-29-0 ]

Reference： [1]Patent: CN108383768,2018,A

22
C₂₄H₃₀N₄O₆S [ No CAS ]
[ 35303-76-5 ]
[ 119018-29-0 ]

Yield	Reaction Conditions	Operation in experiment
93.6%	With propionic acid; In isopropyl alcohol; for 7.5h;Reflux;	10.0 g of the compound, 8.16 g of 4-(2-aminoethyl)benzenesulfonamide, 3.02 g of propionic acid and 50 g of isopropanol were heated under reflux for 7.5 h, cooled at 25 C, filtered and dried at 50 C to give the compound 113.52 g. , the yield was 94.4%, the purity of the HPLC method was 99.63%, the impurity was 0.06%, and the impurities V and VI were not detected.

Reference： [1]Patent: CN110092739,2019,A .Location in patent: Paragraph 0028; 0029; 0030; 0031

Related Products

Historical Records

Pharmaceutical Intermediates of
[ 119018-29-0 ]

Glimepiride Related Intermediates

[ 33483-65-7 ]

trans-4-Methylcyclohexanamine hydrochloride

Related Functional Groups of
[ 119018-29-0 ]

Aryls

[ 318515-70-7 ]

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate

Similarity: 0.78

[ 35303-76-5 ]

4-(2-Aminoethyl)benzenesulfonamide

Similarity: 0.64

[ 6971-74-0 ]

N-Tosylbenzamide

Similarity: 0.62

[ 127-71-9 ]

N-((4-Aminophenyl)sulfonyl)benzamide

Similarity: 0.59

[ 22958-64-1 ]

2-(4-Sulfamoylphenyl)acetic acid

Similarity: 0.58

Amides

[ 318515-70-7 ]

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate

Similarity: 0.78

[ 6971-74-0 ]

N-Tosylbenzamide

Similarity: 0.62

[ 50978-45-5 ]

3-Oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

Similarity: 0.62

[ 127-71-9 ]

N-((4-Aminophenyl)sulfonyl)benzamide

Similarity: 0.59

[ 81-07-2 ]

o-Benzoic Sulfimide

Similarity: 0.58

Ureas

[ 318515-70-7 ]

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate

Similarity: 0.78

[ 29094-61-9 ]

N-(4-(N-(Cyclohexylcarbamoyl)sulfamoyl)phenethyl)-5-methylpyrazine-2-carboxamide

Similarity: 0.57

[ 2044702-76-1 ]

6-(3-((4-Bromophenyl)sulfonyl)ureido)hexanoic acid

Similarity: 0.55

[ 10396-10-8 ]

p-Toluenesulfonylsemicarbazide

Similarity: 0.54

[ 1694-06-0 ]

N-Carbamoyl-4-methylbenzenesulfonamide

Similarity: 0.53

Amines

[ 318515-70-7 ]

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate

Similarity: 0.78

[ 35303-76-5 ]

4-(2-Aminoethyl)benzenesulfonamide

Similarity: 0.64

[ 6971-74-0 ]

N-Tosylbenzamide

Similarity: 0.62

[ 127-71-9 ]

N-((4-Aminophenyl)sulfonyl)benzamide

Similarity: 0.59

[ 22958-64-1 ]

2-(4-Sulfamoylphenyl)acetic acid

Similarity: 0.58

Sulfamides

[ 318515-70-7 ]

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate

Similarity: 0.78

[ 35303-76-5 ]

4-(2-Aminoethyl)benzenesulfonamide

Similarity: 0.64

[ 6971-74-0 ]

N-Tosylbenzamide

Similarity: 0.62

[ 50978-45-5 ]

3-Oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

Similarity: 0.62

[ 127-71-9 ]

N-((4-Aminophenyl)sulfonyl)benzamide

Similarity: 0.59

Related Parent Nucleus of
[ 119018-29-0 ]

Aliphatic Heterocycles

[ 318515-70-7 ]

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate

Similarity: 0.78

[ 122080-99-3 ]

3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one

Similarity: 0.55

[ 7311-93-5 ]

3-(Piperidin-1-ylsulfonyl)benzoic acid

Similarity: 0.54

[ 2096496-06-7 ]

2,2'-((2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)azanediyl)diacetic acid bis-4-methylbenzenesulfonic acid salt

Similarity: 0.54

[ 147636-36-0 ]

1-Tosylpiperidine-4-carboxylic acid

Similarity: 0.54

Pyrrolines

[ 318515-70-7 ]

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate

Similarity: 0.78

[ 2096496-06-7 ]

2,2'-((2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)azanediyl)diacetic acid bis-4-methylbenzenesulfonic acid salt

Similarity: 0.54

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 119018-29-0 ]

Quality Control of [ 119018-29-0 ]

Related Doc. of [ 119018-29-0 ]

Product Details of [ 119018-29-0 ]

Calculated chemistry of [ 119018-29-0 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 119018-29-0 ]

Application In Synthesis of [ 119018-29-0 ]

[ 119018-29-0 ] Synthesis Path-Upstream 1~10

[ 119018-29-0 ] Synthesis Path-Downstream 1~22

Pharmaceutical Intermediates of [ 119018-29-0 ]

Glimepiride Related Intermediates

Related Functional Groups of [ 119018-29-0 ]

Aryls

Amides

Ureas

Amines

Sulfamides

Related Parent Nucleus of [ 119018-29-0 ]

Aliphatic Heterocycles

Pyrrolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Pharmaceutical Intermediates of
[ 119018-29-0 ]

Related Functional Groups of
[ 119018-29-0 ]

Related Parent Nucleus of
[ 119018-29-0 ]