119778-43-7|2,4-Dimethylthiazole-5-carbonyl chloride| Ambeed

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CAS No. :	119778-43-7
Formula :	C₆H₆ClNOS
M.W :	175.64
SMILES Code :	O=C(Cl)C1=C(C)N=C(C)S1
MDL No. :	MFCD26401247

Yield	Reaction Conditions	Operation in experiment
95.0% and 98.0%	In 5,5-dimethyl-1,3-cyclohexadiene;	EXAMPLE 1 In a 300-ml three-neck flask, 7.9 g (0.5) mole) of 2,4-dimethylthiazole-5carboxylic acid were suspended in 200 ml of xylene and under heating and reflux, phosgene was blown at a flow rate of 340 ml/hr for 12 hours (0.18 mole). After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to obtain 8.2 g of <strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> chloride. Its purity and yield were 95.0% and 98.0%, respectively.
97.5% and 98.0%	In N,N-dimethyl-formamide; toluene;	EXAMPLE 10 In a similar apparatus to Example 1, 15.7 g (0.1 mole) of <strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> were suspended in 100 ml of toluene, followed by the addition of 0.1 g of N,N-dimethylformamide. Under heating and reflux, phosgene was blown at a rate of 1.3 l/hr for 5 hours (0.29 mole). After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to obtain 17.2 g of <strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> chloride. Its purity and yield were 97.5% and 98.0%, respectively.
	With thionyl chloride; In dichloromethane; at 20℃; for 1h;	The <strong>[53137-27-2]2,4-dimethyl-thiazole-5-carboxylic acid</strong> (50.0mg, 0.318mmol) and dichloromethane (2mL) into 10mL round bottom flask at 0 was added thionyl chloride (378.43mg, 3.18 mmol) was stirred at room temperature for 1 hour. TLC showed the reaction was complete. The mixture was concentrated to give the title compound as a black solid, used without purification in the next reaction.

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P321
P322
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P378
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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire:
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Storage
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P401
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Disposal
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
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H223	Flammable aerosol
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H228	Flammable solid
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
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H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
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H336	May cause drowsiness or dizziness
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H351	Suspected of causing cancer
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 119778-43-7

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CAS No.: 119778-43-7

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